2011 Winter Project Week:Atrial Fibrillation

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Key Investigators

  • Georgia Tech: Behnood Gholami, Yi Gao, and Allen Tannenbaum

Objective

Atrial fibrillation, a cardiac arrhythmia characterized by unsynchronized electrical activity in the atrial chambers of the heart, is a rapidly growing problem in modern societies. Electrical cardioversion and antiarrhythmic drugs are used to manage this condition, but suffer from low success rates and involve major side effects. In an alternative treatment, known as catheter ablation, specific parts of the left atrium are targeted for radio frequency ablation using an intracardiac catheter. Application of radio frequency energy to the cardiac tissue causes thermal injury (lesions), which in turn results into scar tissue. Successful ablation can eliminate, or isolate, the problematic sources of electrical activity and effectively cure atrial fibrillation.

Magnetic resonance imaging (MRI) has been used for both pre- and and post-ablation assessment of the atrial wall. MRI can aid in selecting the right candidate for the ablation procedure and assessing post-ablation scar formations. Image processing techniques can be used for automatic segmentation of the atrial wall, which facilitates an accurate statistical assessment of the region. As a first step towards the general solution to the computer-assisted segmentation of the left atrial wall, in this research we propose a shape-based image segmentation framework to segment the endocardial wall of the left atrium.

We are developing methods to segment the left atrial wall in delayed-enhanced MR imagery.

Approach, Plan

We plan to finalize a fully-automatic segmentation approach to identify the blood pool in MRAs. The approach uses the robust statistics segmentation framework developed earlier at Georgia Tech.

Progress

  • We proposed a method combining multi-atlas and active contour to perform the segmentation for the endocardial surface.
  • The command line module has been developed and tested on the local built of Slicer3.

References

  • Y. Gao, B. Gholami, R. MacLeod, J. Blauer, W. M. Haddad, and A. R. Tannenbaum, "Segmentation of the Endocardial Wall of the Left Atrium using Localized Region-Based Active Contours and Statistical Shape Learning," Proc. SPIE Med. Imag., San Diego, CA, vol. 7623, 76234Z-1, 2010.
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