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Anatomical Atlas-guided Diffuse Optical Tomography of Brain Activation
Institution:
 1Massachusetts Institute of Technology, Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
3National Food Research Institute, 2-1-12 Kannondai, Tsukuba 305-8642, Japan
Publisher:
 Elsevier Science
Publication Date:
 Jan-2010
Journal:
 Neuroimage
Volume Number:
 49
Issue Number:
 1
Pages:
 561-567
Citation:
 Neuroimage. 2010 Jan 1;49(1):561-7.
PubMed ID:
 19643185
PMCID:
 PMC2858333
Keywords:
 Diffuse optical tomography, MRI, Segmentation, Registration, Inverse problem, Human study, Somatosensory, Anatomical atlas, NIRS
Appears in Collections:
NAC, NA-MIC, SPL
Sponsors:
 P41 RR13218/RR/NCRR NIH HHS/United States
P41 RR14075/RR/NCRR NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
 Custo A., Boas D.A., Tsuzuki D., Dan I., Mesquita R., Fischl B., Grimson W.E.L., Wells III W.M. Anatomical Atlas-guided Diffuse Optical Tomography of Brain Activation. Neuroimage. 2010 Jan 1;49(1):561-7. PMID: 19643185. PMCID: PMC2858333.
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We describe a neuroimaging protocol that utilizes an anatomical atlas of the human head to guide diffuse optical tomography of human brain activation. The protocol is demonstrated by imaging the hemodynamic response to median-nerve stimulation in three healthy subjects, and comparing the images obtained using a head atlas with the images obtained using the subject-specific head anatomy. The results indicate that using the head atlas anatomy it is possible to reconstruct the location of the brain activation to the expected gyrus of the brain, in agreement with the results obtained with the subject-specific head anatomy. The benefits of this novel method derive from eliminating the need for subject-specific head anatomy and thus obviating the need for a subject-specific MRI to improve the anatomical interpretation of diffuse optical tomography images of brain activation.

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