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Prenatal Isolated Mild Ventriculomegaly is Associated with Persistent Ventricle Enlargement at Ages 1 and 2

Institution:	1Department of Psychiatry, University of North Carolina, Chapel Hill, NC, V 2Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, C 3FPG Child Development Institute, University of North Carolina, Chapel Hill, NC, USA. 4Department of Radiology, University of North Carolina, Chapel Hill, NC, USA. 5Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA.
Publisher:	Elsevier Science
Publication Date:	Aug-2012
Journal:	Early Hum Dev
Volume Number:	88
Issue Number:	8
Pages:	691-8
Citation:	Early Hum Dev. 2012 Aug;88(8):691-8.
PubMed ID:	22445211
PMCID:	PMC3386468
Keywords:	Magnetic resonance imaging, Ultrasound, Gray matter, White matter, Cognitive development
Appears in Collections:	NA-MIC
Sponsors:	NIMH Silvio O. Conte Center MH064065 NICHD HD053000 IDDRC P30 HD003110 NRSA T32 NS007431 NIH grant U54 EB005149 (NA-MIC)
Generated Citation:	Lyall A.E., Woolson S., Wolfe H.M., Goldman B.D., Reznick J.S., Hamer R.M., Lin W., Styner M., Gerig G., Gilmore J.H. Prenatal Isolated Mild Ventriculomegaly is Associated with Persistent Ventricle Enlargement at Ages 1 and 2. Early Hum Dev. 2012 Aug;88(8):691-8. PMID: 22445211. PMCID: PMC3386468.
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BACKGROUND: Enlargement of the lateral ventricles is thought to originate from abnormal prenatal brain development and is associated with neurodevelopmental disorders. Fetal isolated mild ventriculomegaly (MVM) is associated with the enlargement of lateral ventricle volumes in the neonatal period and developmental delays in early childhood. However, little is known about postnatal brain development in these children. METHODS: Twenty-eight children with fetal isolated MVM and 56 matched controls were followed at ages 1 and 2years with structural imaging on a 3T Siemens scanner and assessment of cognitive development with the Mullen Scales of Early Learning. Lateral ventricle, total gray and white matter volumes, and Mullen cognitive composite scores and subscale scores were compared between groups. RESULTS: Compared to controls, children with prenatal isolated MVM had significantly larger lateral ventricle volumes at ages 1 and 2years. Lateral ventricle volume at 1 and 2years of age was significantly correlated with prenatal ventricle size. Enlargement of the lateral ventricles was associated with increased intracranial volumes and increased gray and white matter volumes. Children with MVM had Mullen composite scores similar to controls, although there was evidence of delay in fine motor and expressive language skills. CONCLUSIONS: Children with prenatal MVM have persistent enlargement of the lateral ventricles through the age of 2years; this enlargement is associated with increased gray and white matter volumes and some evidence of delay in fine motor and expressive language development. Further study is needed to determine if enlarged lateral ventricles are associated with increased risk for neurodevelopmental disorders.

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