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Abnormal White Matter Connections between Medial Frontal Regions Predict Symptoms in Patients with First Episode Schizophrenia

Institution:
1Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2VA Boston Healthcare System, Boston, MA, USA.
3Safety and Health Organization, Chiba University, Chiba City, Chiba, Japan.
4Laboratory for Mathematical Imaging, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.
Publisher:
Elsevier Science
Publication Date:
Oct-2015
Journal:
Cortex
Volume Number:
71
Pages:
264-76
Citation:
Cortex. 2015 Oct;71:264-76.
PubMed ID:
26277547
PMCID:
PMC4575843
Keywords:
Anterior cingulate cortex, First episode schizophrenia, Fractional anisotropy, Orbitofrontal cortex, White matter
Appears in Collections:
PNL, LMI, NA-MIC, NAC
Sponsors:
K05 MH070047/MH/NIMH NIH HHS/United States
P41 RR013218/RR/NCRR NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH082918/MH/NIMH NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
R01 MH102377/MH/NIMH NIH HHS/United States
R01 AG042512/AG/NIA NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Ohtani T., Bouix S., Lyall A.E., Hosokawa T., Saito Y., Melonakos E., Westin C-F., Seidman L.J., Goldstein J., Mesholam-Gately R., Petryshen T., Wojcik J., Kubicki M. Abnormal White Matter Connections between Medial Frontal Regions Predict Symptoms in Patients with First Episode Schizophrenia. Cortex. 2015 Oct;71:264-76. PMID: 26277547. PMCID: PMC4575843.
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The medial orbitofrontal cortex (mOFC) and rostral part of anterior cingulate cortex (rACC) have been suggested to be involved in the neural network of salience and emotional processing, and associated with specific clinical symptoms in schizophrenia. Considering the schizophrenia dysconnectivity hypothesis, the connectivity abnormalities between mOFC and rACC might be associated with clinical characteristics in first episode schizophrenia patients (FESZ). METHODS: After parcellating mOFC into the anterior and posterior part, diffusion properties of the mOFC-rACC white matter connections for 21 patients with FESZ and 21 healthy controls (HCs) were examined using stochastic tractography, one of the most effective Diffusion Tensor Imaging (DTI) methods for examining tracts between adjacent gray matter (GM) regions. RESULTS: Fractional anisotropy (FA) reductions were observed in bilateral posterior, but not anterior mOFC-rACC connections (left: p < .0001; right: p < .0001) in FESZ compared to HCs. In addition, reduced FA in the left posterior mOFC-rACC connection was associated with more severe anhedonia-asociality (rho = -.633, p = .006) and total score (rho = -.520, p = .032) in the Scale for the Assessment of Negative Symptoms (SANS); reduced FA in the right posterior mOFC-rACC connection was associated with more severe affective flattening (rho = -.644, p = .005), total score (rho = -.535, p = .027) in SANS, hallucinations (rho = -.551, p = .018), delusions (rho = -.632, p = .005) and total score (rho = -.721, p = .001) in the Scale for the Assessment of Positive Symptoms (SAPS) in FESZ. CONCLUSIONS: The observed white matter abnormalities within the connections between mOFC and rACC might be associated with the psychopathology of the early stage of schizophrenia.

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