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Bolus Arrival Time and its Effect on Tissue Characterization with Dynamic Contrast-enhanced Magnetic Resonance Imaging

Institution:
1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2General Electric Global Research, Niskayuna, NY, USA.
3Department of Radiology, Dana Farber Cancer Institute, Boston, MA, USA.
Publisher:
SPIE
Publication Date:
Jan-2016
Journal:
J Med Imaging (Bellingham).
Volume Number:
3
Issue Number:
1
Pages:
014503
Citation:
J Med Imaging (Bellingham). 2016 Jan;3(1):014503.
PubMed ID:
26989759
PMCID:
PMC4773735
Keywords:
bolus arrival time, dynamic contrast-enhanced magnetic resonance imaging, Tofts model, pharmacokinetic analysis, reproducibility, quantitative imaging
Appears in Collections:
NCIGT, NA-MIC, NAC, Prostate Group, SLICER, SPL
Sponsors:
P41 EB015898/EB/NIBIB NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
R01 CA111288/CA/NCI NIH HHS/United States
U01 CA151261/CA/NCI NIH HHS/United States
U24 CA180918/CA/NCI NIH HHS/United States
Generated Citation:
Mehrtash A., Gupta S., Shanbhag D., Miller J.V., Kapur T., Fennessy F.M., Kikinis R., Fedorov A. Bolus Arrival Time and its Effect on Tissue Characterization with Dynamic Contrast-enhanced Magnetic Resonance Imaging. J Med Imaging (Bellingham). 2016 Jan;3(1):014503. PMID: 26989759. PMCID: PMC4773735.
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Matching the bolus arrival time (BAT) of the arterial input function (AIF) and tissue residue function (TRF) is necessary for accurate pharmacokinetic (PK) modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). We investigated the sensitivity of volume transfer constant (Ktrans) and extravascular extracellular volume fraction (v_e) to BAT and compared the results of four automatic BAT measurement methods in characterization of prostate and breast cancers. Variation in delay between AIF and TRF resulted in a monotonous change trend of K^{trans} and v_e values. The results of automatic BAT estimators for clinical data were all comparable except for one BAT estimation method. Our results indicate that inaccuracies in BAT measurement can lead to variability among DCE-MRI PK model parameters, diminish the quality of model fit, and produce fewer valid voxels in a region of interest. Although the selection of the BAT method did not affect the direction of change in the treatment assessment cohort, we suggest that BAT measurement methods must be used consistently in the course of longitudinal studies to control measurement variability.

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Mehrtash-JMI2016-fig8.jpg (150.617kB)