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Antenatal Depression, Treatment with Selective Serotonin Reuptake Inhibitors, and Neonatal Brain Structure: A Propensity-Matched Cohort Study

Institution:
Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Publisher:
Elsevier Science
Publication Date:
Jul-2016
Journal:
Psychiatry Res
Volume Number:
253
Pages:
43-53
Citation:
Psychiatry Res. 2016 Jul 30;253:43-53.
PubMed ID:
27254086
PMCID:
PMC4930375
Keywords:
Antidepressant, Depression, Diffusion tensor imaging, Fetal development, Infant, Newborn, Magnetic resonance imaging
Appears in Collections:
NA-MIC
Sponsors:
K01 MH083045/MH/NIMH NIH HHS/United States
P50 MH064065/MH/NIMH NIH HHS/United States
R01 MH070890/MH/NIMH NIH HHS/United States
R01 MH086633/MH/NIMH NIH HHS/United States
R01 MH092335/MH/NIMH NIH HHS/United States
T32 NS007431/NS/NINDS NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Jha S.C., Meltzer-Brody S., Steiner R.J., Cornea E., Woolson S., Ahn M., Verde A.R., Hamer R.M., Zhu H., Styner M., Gilmore J.H., Knickmeyer R.C. Antenatal Depression, Treatment with Selective Serotonin Reuptake Inhibitors, and Neonatal Brain Structure: A Propensity-Matched Cohort Study. Psychiatry Res. 2016 Jul 30;253:43-53. PMID: 27254086. PMCID: PMC4930375.
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The aim of this propensity-matched cohort study was to evaluate the impact of prenatal SSRI exposure and a history of maternal depression on neonatal brain volumes and white matter microstructure. SSRI-exposed neonates (n=27) were matched to children of mothers with no history of depression or SSRI use (n=54). Additionally, neonates of mothers with a history of depression, but no prenatal SSRI exposure (n=41), were matched to children of mothers with no history of depression or SSRI use (n=82). Structural magnetic resonance imaging and diffusion weighted imaging scans were acquired with a 3T Siemens Allegra scanner. Global tissue volumes were characterized using an automatic, atlas-moderated expectation maximization segmentation tool. Local differences in gray matter volumes were examined using deformation-based morphometry. Quantitative tractography was performed using an adaptation of the UNC-Utah NA-MIC DTI framework. SSRI-exposed neonates exhibited widespread changes in white matter microstructure compared to matched controls. Children exposed to a history of maternal depression but no SSRIs showed no significant differences in brain development compared to matched controls. No significant differences were found in global or regional tissue volumes. Additional research is needed to clarify whether SSRIs directly alter white matter development or whether this relationship is mediated by depressive symptoms during pregnancy.