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Apathy is Associated with Ventral Striatum Volume in Schizophrenia Spectrum Disorder

Institution:
1Brain Imaging Laboratory, Department of Psychiatry, Geisel School of Medicine at Dartmouth/DHMC, Lebanon, NH, USA.
2Program in Neuroscience, Department of Psychology, Bates College, Lewiston, ME, USA.
3Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
4Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Publication Date:
Jul-2016
Journal:
J Neuropsychiatry Clin Neurosci
Volume Number:
28
Issue Number:
3
Pages:
191-4
Citation:
J Neuropsychiatry Clin Neurosci. 2016 Summer;28(3):191-4.
PubMed ID:
26900738
PMCID:
PMC5023440
Appears in Collections:
NA-MIC
Sponsors:
P30 AG010133/AG/NIA NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Roth R.M., Garlinghouse M.A., Flashman L.A., Koven N.S., Pendergrass J.C., Ford J.C., McAllister T.W., Saykin A.J. Apathy is Associated with Ventral Striatum Volume in Schizophrenia Spectrum Disorder. J Neuropsychiatry Clin Neurosci. 2016 Summer;28(3):191-4. PMID: 26900738. PMCID: PMC5023440.
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Apathy is prevalent in schizophrenia, but its etiology has received little investigation. The ventral striatum (VS), a key brain region involved in motivated behavior, has been implicated in studies of apathy. We therefore evaluated whether apathy is associated with volume of the VS on MRI in 23 patients with schizophrenia using voxel-based morphometry. Results indicated that greater self-reported apathy severity was associated with smaller volume of the right VS even when controlling for age, gender, depression, and total gray matter volume. The finding suggests that apathy is related to abnormality of brain circuitry subserving motivated behavior in patients with schizophrenia.