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UNC-Emory Infant Atlases for Macaque Brain Image Analysis: Postnatal Brain Development through 12 Months

Institution:
1Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
2Kitware Inc., Carrboro, NC, USA.
3Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA.
4Division of Autism and Related Developmental Disabilities, Department of Pediatrics, Marcus Autism Center, Children's Healthcare of Atlanta, Emory School of Medicine, Atlanta, GA, USA.
5Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
6Department of Bioengineering, University of California, Riverside, Riverside, CA, USA.
7Department of Child Psychology, Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.
Publication Date:
Jan-2017
Journal:
Front Neurosci.
Volume Number:
10
Pages:
617
Citation:
Front Neurosci. 2017 Jan 10;10:617
PubMed ID:
28119564
PMCID:
PMC5222830
Keywords:
neuroimaging, non-human primate,, Macaque, computational atlases,, white matter pathways, magnetic resonance imaging, diffusion tensor imaging, automatic segmentation
Appears in Collections:
NA-MIC, SLICER
Sponsors:
U54 EB005149/EB/NIBIB NIH HHS/United States
R01 MH086633/MH/NIMH NIH HHS/United States
P50 MH064065/MH/NIMH NIH HHS/United States
R01 MH070890/MH/NIMH NIH HHS/United States
R01 HD053000/HD/NICHD NIH HHS/United States
P50 MH078105/MH/NIMH NIH HHS/United States
R01 MH091645/MH/NIMH NIH HHS/United States
Generated Citation:
Shi Y., Budin F., Yapuncich E., Rumple A., Young J.T., Payne C., Zhang X., Hu X., Godfrey J., Howell B., Sanchez M., Styner M.A. UNC-Emory Infant Atlases for Macaque Brain Image Analysis: Postnatal Brain Development through 12 Months. Front Neurosci. 2017 Jan 10;10:617 PMID: 28119564. PMCID: PMC5222830.
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Computational anatomical atlases have shown to be of immense value in neuroimaging as they provide age appropriate reference spaces alongside ancillary anatomical information for automated analysis such as subcortical structural definitions, cortical parcellations or white fiber tract regions. Standard workflows in neuroimaging necessitate such atlases to be appropriately selected for the subject population of interest. This is especially of importance in early postnatal brain development, where rapid changes in brain shape and appearance render neuroimaging workflows sensitive to the appropriate atlas choice. We present here a set of novel computation atlases for structural MRI and Diffusion Tensor Imaging as crucial resource for the analysis of MRI data from non-human primate rhesus monkey (Macaca mulatta) data in early postnatal brain development. Forty socially-housed infant macaques were scanned longitudinally at ages 2 weeks, 3, 6, and 12 months in order to create cross-sectional structural and DTI atlases via unbiased atlas building at each of these ages. Probabilistic spatial prior definitions for the major tissue classes were trained on each atlas with expert manual segmentations. In this article we present the development and use of these atlases with publicly available tools, as well as the atlases themselves, which are publicly disseminated to the scientific community.

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