Difference between revisions of "Projects:fMRIAnalysisAnxietyDisorder"

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Main hypotheses:
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Objectives:  
1. variants of candidate genes predict different fMRI activation patterns in selected brain regions in patients vs. controls when processing threatening stimuli
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1. to explore how variants of candidate genes predict different fMRI activation patterns in selected brain regions in patients vs. controls when processing threatening stimuli
2. combination of autonomic measures, fMRI activation patterns and genetic variants reveal more specific subtypes of PD
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2. to combine autonomic measures, fMRI activation patterns and genetic variants reveal more specific subtypes of PD
3. repeated exposure to the threatening stimuli changes the fMRI pattern and possibly the electrophysiological response
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3. to evaluate how repeated exposure to the threatening stimuli changes the fMRI pattern and possibly the electrophysiological response
  
Sample:
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Progress:
30 PD with Agoraphobia, meeting criteria of DSM-IV, recruited from the Anxiety Disorder Clinic of the CAMH
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The study is currently in the recruitment phase. 30 PD with Agoraphobia, meeting criteria of DSM-IV, will be recruited from the Anxiety Disorder Clinic of the CAMH and 20 healthy control subjects recruited by means of a flyer.
20 healthy control subjects recruited by means of a flyer
 
  
Stimuli:
 
VR environment for panic disorder from VEPSY (www.vepsy.com www.cybertherapy.info), control stimulus VR environment for social phobia (dinner table, meeting table or similar), baseline stimulus
 
  
VEPSY: Europe based project to develop virtual reality for treatment of anxiety disorders.
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Key Investigators: Claudia Rothe, Peter Soros, Simon Graham, James Kennedy
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Links: www.vepsy.com; www.cybertherapy.info (VEPSY: Europe based project to develop virtual reality for treatment of anxiety disorders)

Revision as of 18:14, 29 April 2007

Home < Projects:fMRIAnalysisAnxietyDisorder

Objectives: 1. to explore how variants of candidate genes predict different fMRI activation patterns in selected brain regions in patients vs. controls when processing threatening stimuli 2. to combine autonomic measures, fMRI activation patterns and genetic variants reveal more specific subtypes of PD 3. to evaluate how repeated exposure to the threatening stimuli changes the fMRI pattern and possibly the electrophysiological response

Progress: The study is currently in the recruitment phase. 30 PD with Agoraphobia, meeting criteria of DSM-IV, will be recruited from the Anxiety Disorder Clinic of the CAMH and 20 healthy control subjects recruited by means of a flyer.


Key Investigators: Claudia Rothe, Peter Soros, Simon Graham, James Kennedy

Links: www.vepsy.com; www.cybertherapy.info (VEPSY: Europe based project to develop virtual reality for treatment of anxiety disorders)