https://www.na-mic.org/w/api.php?action=feedcontributions&feedformat=atom&user=Jdwest 2026-04-14T17:54:57Z User contributions MediaWiki 1.33.0 https://www.na-mic.org/w/index.php?title=Projects:MorphometryFrontalCircuitry&diff=10014 2007-05-03T20:09:24Z

<p>Jdwest: </p> <hr /> <div>'''Objective:''' To see how morphometry of various frontal circuitry structures relates to substance use disorder in schizophrenia.<br /> <br /> '''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls. Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister, Nancy Koven<br /> * Isomics: Steve Pieper</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:MorphometryFrontalCircuitry&diff=10013 2007-05-03T20:08:54Z

<p>Jdwest: </p> <hr /> <div>'''Objective:''' To see how morphometry of various frontal circuitry structures relates to substance use disorder in schizophrenia.<br /> <br /> '''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls. Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister<br /> * Isomics: Steve Pieper</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:MorphometryFrontalCircuitry&diff=10010 2007-05-03T19:59:10Z

<p>Jdwest: </p> <hr /> <div>'''Objective:''' To see how morphometry of various frontal circuitry structures relates to substance use disorder.<br /> <br /> '''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls. Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister<br /> * Isomics: Steve Pieper</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:MorphometryFrontalCircuitry&diff=10009 2007-05-03T19:58:22Z

<p>Jdwest: </p> <hr /> <div>'''Objective:''' To see how morphometry of various frontal circuitry structures relates to substance use disorder.<br /> <br /> '''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls. Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:FrontoTemporalConnectivityInSchizophreniaDuringSemanticMemory&diff=9989 2007-05-03T18:50:27Z

<p>Jdwest: </p> <hr /> <div> Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]<br /> <br /> '''Objective:''' In this project, an event-related auditory semantic memory task is administered. Participants are presented with a semantic category and required to decide whether a subsequent word is a member of the category (e.g., vehicle-bus). To control for phonological processing, other items require a match-mismatch decision between pseudo-words constructed from reordered semantic items (e.g., yodb-rea).<br /> <br /> '''Progress:''' To date, 6 patients with schizophrenia and 3 healthy controls have been studied with this task. Data will be available in year three.<br /> <br /> '''Year Three Update:'''<br /> Data collection and analysis is ongoing. Updated results are expected at the end of year three.<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Andrew Saykin, Robert Roth, Laura Flashman, John West, Thomas McAllister<br /> * Harvard: Martha Shenton, Marek Kubicki<br /> <br /> '''Links'''<br /> <br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:BrainActivationDuringContinuousVerbalEncodingAndRecognitionTaskInSchizophrenia&diff=9988 2007-05-03T18:50:01Z

<p>Jdwest: </p> <hr /> <div> Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]<br /> <br /> '''Objective:''' This project employs an event-related auditory verbal episodic memory probe targeting medial temporal and DLPFC circuitry. The task uses a continuous performance format where concrete nouns are presented initially as new items. Words are then repeated after short or long intervals and the participant is required to make a new/old distinction. This design permits analysis of both encoding and recognition processes.<br /> <br /> '''Progress:''' To date, data have been collected on 8 patients with schizophrenia and 5 healthy controls. Preliminary analysis on a subset of this data has been completed (see figure below). Sample data is available and more data will become available in year three.<br /> <br /> [[Image:NAMIC_AVrecog_prelim_results.jpg|[[Image:NAMIC_AVrecog_prelim_results.jpg|Image:NAMIC_AVrecog_prelim_results.jpg]]]]<br /> <br /> '''Year Three Update:'''<br /> Data collection and analysis is ongoing. Updated results are expected at the end of year three.<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Andrew Saykin, Robert Roth, Laura Flashman, John West, Thomas McAllister<br /> * Harvard: Martha Shenton, Marek Kubicki<br /> <br /> '''Links'''<br /> <br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * Sample Data: https://portal.nbirn.net/BIRN/cgi-bin/DataGrid/browse.cgi?browseloc=/home/Projects/NAMIC__0003/Files/Dartmouth/HealthyControls6</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:NeuralSubstratesOfWorkingMemoryInSchizophrenia&diff=9987 2007-05-03T18:49:13Z

<p>Jdwest: </p> <hr /> <div>'''Objective:''' This project assesses working memory using an auditory verbal version of the n-back task paradigm. Three conditions are presented in blocks in counterbalanced order with increasing working memory load demands (0-, 1-, 2- and 3-back). We will use NAMIC tools to perform novel analyses of the relationships between brain activation and morphological data (e.g., ROI volumes, DTI) in order to improve our understanding of structure-function relationships and connectivity in schizophrenia.<br /> <br /> '''Progress:''' To date, 16 patients with schizophrenia and 13 healthy controls have been studied. Preliminary analyses on a subgroup have been completed (see image below). Data will be available in year three.<br /> <br /> [[Image:NAMIC_prelim_n2bk_results_good.jpg|Image:NAMIC_prelim_n2bk_results_good.jpg]]]]<br /> <br /> '''Year Three Update'''<br /> <br /> '''Objective:''' We examined the self-perception of executive functions in patients with schizophrenia, and evaluated whether the subjective integrity of working memory was related to brain activation during performance on a working memory task.<br /> <br /> '''Progress:''' To date, data has been analyzed for 21 patients with schizophrenia and 17 healthy controls have completed the Behavior Rating Inventory of Executive Function - Adult version (BRIEF-A) Self Report form, and a subset (10 patients, 8 controls) completed an auditory-verbal 3-back working memory task while undergoing functional magnetic resonance imaging (fMRI). Preliminary analyses showed that patients reported significantly more daily problems than controls for most aspects of executive functions, the working memory scale yielding the largest effect size (partial eta-squared = 0.35), and were less accurate during the 3-back. Patients also showed the expected bilateral DLPFC hypoactivation during the task. Regression analyses revealed that subjectively better working memory functioning in daily life was associated with greater bilateral DLPFC activation in the patient group during the scan. The findings suggest that patients with schizophrenia can identify problems with their working memory in daily life, and that this perception relates to abnormality of neural circuitry subserving working memory.<br /> <br /> [[Image:NBack_BriefA_corr.JPG|Image:NBack_BriefA_corr.JPG]]<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Robert Roth, Laura Flashman, Jo Cara Pendergrass, Nancy Koven, Matthew Garlinghouse, Thomas McAllister, Andrew Saykin<br /> * BWH: Martha Shenton, Marek Kubicki<br /> <br /> '''Links'''<br /> <br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:BrainActivationDuringContinuousVerbalEncodingAndRecognitionTaskInSchizophrenia&diff=9986 2007-05-03T18:48:11Z

<p>Jdwest: </p> <hr /> <div> Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]<br /> <br /> '''Objective:''' This project employs an event-related auditory verbal episodic memory probe targeting medial temporal and DLPFC circuitry. The task uses a continuous performance format where concrete nouns are presented initially as new items. Words are then repeated after short or long intervals and the participant is required to make a new/old distinction. This design permits analysis of both encoding and recognition processes.<br /> <br /> '''Progress:''' To date, data have been collected on 8 patients with schizophrenia and 5 healthy controls. Preliminary analysis on a subset of this data has been completed (see figure below). Sample data is available and more data will become available in year three.<br /> <br /> [[Image:NAMIC_AVrecog_prelim_results.jpg|[[Image:NAMIC_AVrecog_prelim_results.jpg|Image:NAMIC_AVrecog_prelim_results.jpg]]]]<br /> <br /> '''Year Three Update'''<br /> Data collection and analysis is ongoing. Updated results are expected at the end of year three.<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Andrew Saykin, Robert Roth, Laura Flashman, John West, Thomas McAllister<br /> * Harvard: Martha Shenton, Marek Kubicki<br /> <br /> '''Links'''<br /> <br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * Sample Data: https://portal.nbirn.net/BIRN/cgi-bin/DataGrid/browse.cgi?browseloc=/home/Projects/NAMIC__0003/Files/Dartmouth/HealthyControls6</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:NeuralSubstratesOfWorkingMemoryInSchizophrenia&diff=9985 2007-05-03T18:45:31Z

<p>Jdwest: </p> <hr /> <div>'''Objective:''' This project assesses working memory using an auditory verbal version of the n-back task paradigm. Three conditions are presented in blocks in counterbalanced order with increasing working memory load demands (0-, 1-, 2- and 3-back). We will use NAMIC tools to perform novel analyses of the relationships between brain activation and morphological data (e.g., ROI volumes, DTI) in order to improve our understanding of structure-function relationships and connectivity in schizophrenia.<br /> <br /> '''Progress:''' To date, 16 patients with schizophrenia and 13 healthy controls have been studied. Preliminary analyses on a subgroup have been completed (see image below). Data will be available in year three.<br /> <br /> [[Image:NAMIC_prelim_n2bk_results_good.jpg|Image:NAMIC_prelim_n2bk_results_good.jpg]]]]<br /> <br /> '''Year 3 Update'''<br /> <br /> '''Objective:''' We examined the self-perception of executive functions in patients with schizophrenia, and evaluated whether the subjective integrity of working memory was related to brain activation during performance on a working memory task.<br /> <br /> '''Progress:''' To date, data has been analyzed for 21 patients with schizophrenia and 17 healthy controls have completed the Behavior Rating Inventory of Executive Function - Adult version (BRIEF-A) Self Report form, and a subset (10 patients, 8 controls) completed an auditory-verbal 3-back working memory task while undergoing functional magnetic resonance imaging (fMRI). Preliminary analyses showed that patients reported significantly more daily problems than controls for most aspects of executive functions, the working memory scale yielding the largest effect size (partial eta-squared = 0.35), and were less accurate during the 3-back. Patients also showed the expected bilateral DLPFC hypoactivation during the task. Regression analyses revealed that subjectively better working memory functioning in daily life was associated with greater bilateral DLPFC activation in the patient group during the scan. The findings suggest that patients with schizophrenia can identify problems with their working memory in daily life, and that this perception relates to abnormality of neural circuitry subserving working memory.<br /> <br /> [[Image:NBack_BriefA_corr.JPG|Image:NBack_BriefA_corr.JPG]]<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Robert Roth, Laura Flashman, Jo Cara Pendergrass, Nancy Koven, Matthew Garlinghouse, Thomas McAllister, Andrew Saykin<br /> * BWH: Martha Shenton, Marek Kubicki<br /> <br /> '''Links'''<br /> <br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]</div>

Jdwest https://www.na-mic.org/w/index.php?title=File:NBack_BriefA_corr.JPG&diff=9984 2007-05-03T18:44:34Z

<p>Jdwest: Brain Activation During N-Back Inversely Correlated with BRIEF-A Working Memory Score</p> <hr /> <div>Brain Activation During N-Back Inversely Correlated with BRIEF-A Working Memory Score</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:NeuralSubstratesOfWorkingMemoryInSchizophrenia&diff=9983 2007-05-03T18:42:55Z

<p>Jdwest: </p> <hr /> <div>'''Objective:''' This project assesses working memory using an auditory verbal version of the n-back task paradigm. Three conditions are presented in blocks in counterbalanced order with increasing working memory load demands (0-, 1-, 2- and 3-back). We will use NAMIC tools to perform novel analyses of the relationships between brain activation and morphological data (e.g., ROI volumes, DTI) in order to improve our understanding of structure-function relationships and connectivity in schizophrenia.<br /> <br /> '''Progress:''' To date, 16 patients with schizophrenia and 13 healthy controls have been studied. Preliminary analyses on a subgroup have been completed (see image below). Data will be available in year three.<br /> <br /> [[Image:NAMIC_prelim_n2bk_results_good.jpg|[[Image:NAMIC_prelim_n2bk_results_good.jpg|Image:NAMIC_prelim_n2bk_results_good.jpg]]]]<br /> <br /> '''Year 3 Update'''<br /> <br /> '''Objective:''' We examined the self-perception of executive functions in patients with schizophrenia, and evaluated whether the subjective integrity of working memory was related to brain activation during performance on a working memory task.<br /> <br /> '''Progress:''' To date, data has been analyzed for 21 patients with schizophrenia and 17 healthy controls have completed the Behavior Rating Inventory of Executive Function - Adult version (BRIEF-A) Self Report form, and a subset (10 patients, 8 controls) completed an auditory-verbal 3-back working memory task while undergoing functional magnetic resonance imaging (fMRI). Preliminary analyses showed that patients reported significantly more daily problems than controls for most aspects of executive functions, the working memory scale yielding the largest effect size (partial eta-squared = 0.35), and were less accurate during the 3-back. Patients also showed the expected bilateral DLPFC hypoactivation during the task. Regression analyses revealed that subjectively better working memory functioning in daily life was associated with greater bilateral DLPFC activation in the patient group during the scan. The findings suggest that patients with schizophrenia can identify problems with their working memory in daily life, and that this perception relates to abnormality of neural circuitry subserving working memory.<br /> <br /> <br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Robert Roth, Laura Flashman, Jo Cara Pendergrass, Nancy Koven, Matthew Garlinghouse, Thomas McAllister, Andrew Saykin<br /> * BWH: Martha Shenton, Marek Kubicki<br /> <br /> '''Links'''<br /> <br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]</div>

Jdwest https://www.na-mic.org/w/index.php?title=2007_Annual_Scientific_Report&diff=9713 2007-04-25T16:47:35Z

<p>Jdwest: /* 2.3 Functional MRI Analysis Theme (Polina Golland, Andy Saykin) */</p> <hr /> <div>Back to [[2007_Progress_Report]]<br /> <br /> For reference: <br /> <br /> *[[Media:2006_Submitted_NA-MIC_Scientific_Report.pdf|2006 Annual Scientific Report]], [[Media:2006_APR_NIH_Questions_and_Answers.pdf|2006 Followup Questions and Answers]].<br /> *[[Media:2005_NAMIC_Specialized_ProgReport.pdf|2005 Annual Scientific Report]]<br /> <br /> == 1. Introduction (Marty Shenton)==<br /> <br /> == 2. Four Main Themes ==<br /> <br /> This year's activities focus on four main themes: Diffusion Image Analysis, Structural Analysis, Functional MRI Analysis, and the NA-MIC Kit. Each of the following sections begins with an overview of the theme, provides a progress update and list of key investigators, and concludes with a set of links to additional information for individual projects in that theme.<br /> <br /> These thematic activities involve scientists from each of the 7 NA-MIC cores (Appendix).<br /> <br /> * Core 1 Algorithms-Ross Whitaker PI<br /> * Core 2 Engineering-Will Schroeder PI<br /> * Core 3 DBP1-Martha Shenton PI / DBP2-Andy Saykin PI / DBP3-Steven Potkin PI<br /> * Core 4 Service-Will Schroeder PI<br /> * Core 5 Training-Randy Gollub PI<br /> * Core 6 Dissemination-Tina Kapur Co-PI; Steve Pieper Co-PI<br /> * Core 7 Leadership-Ron Kikinis<br /> <br /> === 2.1 Diffusion Image Analysis Theme (Marek Kubicki, Guido Gerig)===<br /> <br /> ==== Progress ====<br /> <br /> <br /> <br /> ==== Key Investigators ====<br /> <br /> * BWH: Martha Shenton, Marek Kubicki, Marc Niethammer, Sylvain Bouix, Katharina Quintus, Mark Dreusicke, Carl-Fredrik Westin, Raul San Jose, Gordon Kindlmann, Doug Markant<br /> * Harvard/MGH: Bruce Fischl, Denis Jen, David Kennedy<br /> * MIT: Lauren O'Donnell<br /> * UCI: James Fallon, Martina Panzenboeck<br /> * UNC: Guido Gerig, Isabelle Corouge, Casey Goodlett, Martin Styner<br /> * Utah: Tom Fletcher, Ross Whitaker, Saurav Basu<br /> * Georgia Tech: Eric Pichon, John Melonakos, Xavier LeFaucheur, Allen Tannenbaum<br /> * Dartmouth: John West, Andrew Saykin, Laura Flashman, Paul Wang, Heather Pixley, Robert Roth<br /> * Isomics: Steve Pieper<br /> <br /> ==== Additional Information ====<br /> <br /> For details of each of the projects in this theme, please see [[NA-MIC_Internal_Collaborative_Projects#Diffusion_Image_Analysis|NA-MIC Projects on Diffusion Image Analysis]].<br /> <br /> === 2.2 Structural Analysis Theme (Allen Tannenbaum, Martin Styner)===<br /> <br /> ==== Progress ====<br /> <br /> '''Shape Driven Segmentation'''<br /> <br /> The characterization of local variations specific to a shape population is an important problem in medical imaging since a given disease usually only effects a portion of an organ’s surface. In particular, one of the driving biological projects that motivates our work is the study of schizophrenia. Yet the clinical study of schizophrenia is only now beginning to take concrete form, primarily because neuroimaging techniques are finally providing a sufficiently detailed picture of the structure of the living brain and tracking the way the brain functions in controlled experimental settings. One important aspect of such an analysis of schizophrenia is the segmentation and shape analysis of selected brain structures, such as the hippocampus or the caudate nucleus, in order to find differences between groups of healthy and diseased patients. An automated segmentation of such structures must therefore be highly accurate and include high frequency variations in the surface. Since shape representation is a key component of the segmentation, it must be rich enough to express shape variations at various frequency levels, from low harmonics to sharp edges. Additionally, a shape representation that encodes variations at multiple scales can be useful in itself as a rich feature set for shape analysis and classification.<br /> <br /> Medical object segmentation with deformable models and statistical shape modeling may be combined to obtain a more robust and accurate segmentation. To address this issue, a decomposable shape representation targeted to the population seems natural, where the shape parameters are separated into groups that describe independent global and/or local biological variations in the population, and a prior induced over each group explicitly encodes these variations. Wavelet basis functions are useful for such a representation since they range from functions with global support to functions localized both in frequency and space, so that their coefficients can be used both as global and local shape descriptors, unlike Fourier basis functions or principal components over landmarks which are global shape descriptors. Our work presents three novel contributions for shape representation, multiscale prior probability estimation and segmentation.<br /> <br /> ==== Key Investigators ====<br /> <br /> * MIT: Kilian Pohl, Sandy Wells, Eric Grimson<br /> * UNC: Martin Styner, Ipek Oguz, Guido Gerig<br /> * Utah: Ross Whitaker, Suyash Awate, Tolga Tasdizen, Tom Fletcher, Joshua Cates, Miriah Meyer<br /> * GaTech: Allen Tannenbaum, John Melonakos, Tauseef ur Rehman, Shawn Lankton, Ramsey Al-Hakim, Eric Pichon, Delphine Nain, Oleg Michailovich, Yogesh Rathi, James Malcolm<br /> * Steve Pieper, Bill Lorensen, Luis Ibanez, Karthik Krishnan, Michael J. Pan, Jagadeeswaran Rajendiran, Jim Miller, Karthik Krishnan, Luis Ibanez<br /> * Harvard PNL: Sylvain Bouix, Motoaki Nakamura, Min-Seong Koo, Martha Shenton, Marc Niethammer, Jim Levitt<br /> * Dartmouth: Andrew Saykin<br /> * UCI: James Fallon<br /> <br /> ==== Additional Information ====<br /> <br /> For details of each of the projects in this theme, please see [[NA-MIC_Internal_Collaborative_Projects#Structural_Image_Analysis|NA-MIC Projects on Structural Image Analysis]].<br /> <br /> === 2.3 Functional MRI Analysis Theme (Polina Golland, Andy Saykin)===<br /> <br /> * Imaging Phenotypes in Schizophrenics and Controls (Turner, Kennedy, Potkin, UCI)<br /> <br /> Functional connectivity of the DLPFC by genotype was investigated using partial least squares (PLS) correlation analysis. PLS is a multivariate analytical technique used to summarize large neuroimaging data sets in such a way as to correlate patterns of activation with a variable(s) of interest (i.e., DLPFC activity). In the most recent analysis, the DRD1 genotype was used as a grouping variable. This analysis has been submitted for publication (Tura, Turner, Fallon, Kennedy, and Potkin. &lt;i&gt;Genetic Impact on Functional Connectivity in Schizophrenics During a Working Memory Task&lt;/i&gt;)<br /> <br /> Working memory performance did not differ significantly between the two cohorts. However, imaging-genetic analysis showed a significant difference (P&lt; 0.05) between the circuitry engaged by each group. Significance and reliability of the resulting imaging-behavioral patterns within each genotype were assessed by 200 bootstrap and 500 permutation tests, respectively. In one group, the circuitry included the temporal pole, the insula, the dorsolateral prefrontal cortex, and the Brodmann Areas (BA) 1,2,3,4,6,11 and 21, while the other group showed a network comprising the tectum, precuneus retroplenial, vermis, substantia nigra, BA 22,39,8, and 9. The DRD1 polymorphic site may characterize circuitry differences in schizophrenic patients.<br /> <br /> * Path-Of-Interest Analysis (joint DTI/fMRI modeling)<br /> <br /> We collected preliminary data using an application of the “optimal path analysis”. In this analysis, we extracted group fMRI activation due to the Stroop effect (attentional experiment where incongruent color, in which the word is written, competes with name of the color itself, activating areas responding to conflict monitoring and selection) separately for controls and schizophrenics. This resulted in three clusters of activation, one in the right Dorsolateral Prefrontal Cortex, a second in the Anterior Cingulate Gyrus, and a third in the Medial Parietal Lobe. In the next step, we placed activation clusters in each individual space, by reversing normalization parameters used during fMRI analysis. Finally, EPI fMRI scans were co-registered to DTI scans, and the same registration parameters were applied to activation maps (fMRI results).<br /> <br /> Regions of activation were used as start and destination points for optimal path analysis, which resulted in three separate paths of optimal connectivity for each subject. The probability of the connections were then calculated for each path and each subject, and compared between groups. In our preliminary analysis we included 10 control subjects and 10 chronic schizophrenics. Our results demonstrated a relationship between Stroop Effect fMRI activation in the medial parietal area and optimal path connectivity between parietal and cingulate activation sites in schizophrenics (rho=-0.56; p=0.047), which was not observed in controls. These findings suggest that decreased connectivity may result in schizophrenics relying more on posterior parts of the executive attentional network during performance of the Stroop task.<br /> <br /> * Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers<br /> <br /> We performed a combined DTI, fMRI, and morphometric study on 13 patients with schizophrenia (SZ) and 14 HC. We identified areas of increased trace diffusivity (TD) in the hippocampal and insular regions as well as areas of reduced fractional anisotropy (FA) in left frontal white matter in SZ relative to HC (p&lt;.01). Voxel based morphometry analyses in a subset of these subjects showed corresponding reductions in gray matter density in hippocampal and insular regions in patients relative to controls (p&lt;.01). Analysis of fMRI results from the novel vs. repeated word contrast from the event-related auditory verbal episodic memory encoding/retrieval task in a subset of the subjects indicated reduced activation in frontal and temporal regions, as well as increased activation in posterior cingulate, retrosplenial, and thalamic regions in SZ relative to HC (p&lt;.05). Further analysis showed that left frontal white matter FA was associated with activation in the left and right hippocampi as well as other frontal and temporal regions, but inversely related to activation in the retrosplenial/posterior cingulate region (p&lt;.05). These initial findings indicate a pattern of relationships between of structural and functional brain abnormalities in schizophrenia and demonstrate the feasibility of integrated quantitative analyses across modalities.<br /> <br /> === 2.4 [[NA-MIC-Kit|NA-MIC Kit]] Theme (Will Schroeder)===<br /> <br /> ==== Progress ====<br /> <br /> <br /> <br /> ==== Key Investigators ====<br /> <br /> * GE: Bill Lorensen, Jim Miller, Xiaodong Tao, Dan Blezek<br /> * Isomics: Steve Pieper, Alex Yarmarkovich<br /> * Kitware: Will Schroeder, Luis Ibanez, Karthik Krishnan, Andy Cedilnik, Sebastien Barre, Mathieu Malaterre<br /> * UCLA: Mike Pan, Jagadeeswaran Rajendiran<br /> * UCSD: Neil Jones, Jeffrey Grethe<br /> * Harvard: Nicole Aucoin, Katie Hayes, Wendy Plesniak, Mike Halle, Gordon Kindlmann, Raul San Jose Estepar, Haiying Liu, Ron Kikinis<br /> * MIT: Lauren O'Donnell, Kilian Pohl<br /> <br /> ==== Additional Information ====<br /> <br /> For details of each of the projects in this theme, please see [[NA-MIC_Internal_Collaborative_Projects#NA-MIC_Kit|NA-MIC Kit Projects]].<br /> <br /> == 3. Highlights (Will Schroeder)==<br /> <br /> === 3.1 Slicer3 ===<br /> * Slicer3<br /> <br /> * EM Segmenter (http://wiki.na-mic.org/Wiki/index.php/Slicer3:EM)&lt;br&gt;We constructed a module that integrates the EMSegment algorithm---an automatic segmentation algorithm for medical images---into the Slicer3 platform. The project was a joint effort between the NAMIC engineering, algorithms, and biological problem cores. As in Slicer 2, the user is able to adjust the algorithm to a variety of imaging protocols as well as anatomical structures. However, the configuration of the algorithm is greatly simplified in Slicer 3 as the user is guided by a new wizard-style workflow interface.&lt;br&gt; A tutorial session for the EMSegment module was given at the January 2007 NAMIC all-hands meeting (notes and data available online at http://wiki.na-mic.org/Wiki/index.php/Slicer3:EM). The module is available with the beta release of Slicer3. Future work includes testing, validation, and the integration of data preprocessing steps into the EMSegment module.<br /> <br /> === 3.2 Algorithms ===<br /> <br /> * As we published for the first time an open-source framework to do shape analysis in this NAMIC year, I think this is a highlight. It has been downloaded many times since the first online publication (around October 06) and it now used by several image analysis groups (not yet by the clinical researchers, we still need to package it nicely into Slicer v3). I updated our shape analysis page last week. The webpage with the information is here http://www.na-mic.org/Wiki/index.php/Algorithm:UNC:Shape_Analysis.<br /> <br /> * Highlights [Algorithmic Development and Software Transfer at Georgia Tech]:<br /> ** The spherical based wavelet shape analysis package has been put into ITK, and in the next few months the multiscale segmentation work will be incorporated as well. We then intend to import this menu of algorithmsin to 3D Slicer. All of our algorithms are open source, and are intended to be user friendly to give them the widest possible accessibility.<br /> ** We have implemented a very fast method for the optimal transport approach to elastic image registration. This will be made available via ITK in the next year.<br /> ** Our tool for the semi-automated segmentation of DPFC areas in coronal sections of from brain MRI data developed in collaboration with our Core 3 colleague Dr. James Fallon is in Slicer 2. This will be ported to Slicer 3 in the next year as well.<br /> ** ITK code has been for the conformal flattening procedure has been ported to an ITK filter and is in the NAMIC Sandbox.<br /> <br /> === 3.3 Outreach ===<br /> * Papers- Number of algorithms papers (count the number of NAMIC MICCAI papers accepted - it was significant). In fact, all 3 DTI papers presented at MICCAI last year were NAMIC associated.<br /> * Highlight a tutorial or other training event. E.g. attendance at the UNC-DTI workshop was good and there will be another such workshop at HBM<br /> <br /> == 4. Impact and Value to Biocomputing (Jim Miller)==<br /> <br /> <br /> === 4.1 Impact within the Center ===<br /> <br /> <br /> <br /> === 4.2 Impact within NIH Funded Research ===<br /> <br /> <br /> <br /> === 4.3 National and International Impact ===<br /> <br /> == 5.NA-MIC Timeline (Ross Whitaker)==<br /> <br /> This section provides a table of NAMIC timelines from the original proposal that graphically depicts completed tasks/goals in years 1, 2, and 3 and tasks/goals to be completed in years 4-5. Changes to the original timelines have also been described.<br /> <br /> [[2007_Scientific_Report_Timeline|2007 Scientific Report Timeline]]<br /> <br /> == 6. EAB Report ==<br /> <br /> The NA-MIC External Advisory Board (EAB), chaired by Prof. Chris Johnson of the University of Utah, met at the annual All-Hands Meeting. After individual presentations by NA-MIC investigators and open as well as closed-door EAB discussion, the Board provided its independent expert assessment of the Center (Appendix 2).<br /> <br /> = Logistics =<br /> <br /> == Schedule and process for preparation of this report ==<br /> <br /> * March 30 - Assign section/theme leads (Ron). Last year: introduction (marty), structural analysis (allen, martin), dti (guido, marty/marek), fmri (polina, andy), namic kit(bill), timeline (ross), highlights (will), impact (bill).<br /> *April 7,10 - tcons with Marty, Ross, Will, Tina to finalize the layout, process, and timeline of report.<br /> * April 13 - update projects list using last year's [[NA-MIC_Collaborations]] and [[2007_Project_Half_Week#Projects|projects pursued at the half week in SLC]]. Remind investigators to update individual pages. (Tina)<br /> * April 23- complete project description pages in updated list: [[NA-MIC_Collaborations]] (all project owners).<br /> * April 30 - complete section summaries, introduction, highlights, impact, timeline (owners of these topics)<br /> * May 3 - submit wiki report to NA-MIC editor, Ann (Tina)<br /> * May 17 - submit Edited report to Rachana (Ann)<br /> * May 31 - ship final package to NIH (Rachana)<br /> <br /> == Guidelines from NIH Program Officer ==<br /> <br /> The following guidelines were provided by Grace Peng, NA-MIC program officer, in Feb 2006.<br /> <br /> The key is to synthesize all the individual elements into bigger picture stories that really speak of each area’s impact to the community.<br /> <br /> The specialized scientific report should have the following format:<br /> <br /> # Introductory page describing the new grouping of NAMIC project themes.<br /> # A description of progress in each NAMIC project theme (not to exceed 2 pages each), tying together relevant activities from participating subcomponents and referencing cores in parentheses.<br /> # A table of NAMIC timelines (from original proposal), graphically depicting completed tasks/goals in years 1,2, and 3 and tasks/goals to be completed in years 4-5. Changes to the original timelines should be described.<br /> # A description of 3 highlights selected from all NAMIC projects to showcase NAMIC.<br /> # A discussion of NAMIC’s impact and value to the biocomputing community this year.</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:AHM_2007_progress&diff=9501 2007-04-20T17:52:04Z

<p>Jdwest: </p> <hr /> <div>'''Path of Interest Progress:'''<br /> <br /> * John West trained with Dennis Jen on use of new version.<br /> * Supplied Dennis with 3 sample Philips 3T Data Sets and went over format for reading into POI algorithm.<br /> * Helped with implementation of POI into Slicer 3.<br /> <br /> '''Fiber Tractography Training and DTI discussion:'''<br /> <br /> * John West met with Sylvain Bouix to go over fibre tracking techniques and methods for analysis.<br /> * Got Sylvain's opinion on current 1.5 T data.<br /> * Discussed with Sylvain, Marty Shenton and others on potential collaborative papers (e.g. cingulate bundle in schizophrenics vs. controls)<br /> * Shared some 3T Philips DTI data with Sylvain to compare with Harvard's current 3T GE data.</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:AHM_2007_progress&diff=9500 2007-04-20T17:51:41Z

<p>Jdwest: </p> <hr /> <div>'''Path of Interest Progress:'''<br /> <br /> * John West trained with Dennis Jen on use of new version.<br /> * Supplied Dennis with 3 sample Philips 3T Data Sets and went over format for reading into POI algorithm.<br /> * Helped with implementation of POI into Slicer 3.<br /> <br /> '''Fiber Tractography Training:'''<br /> <br /> * John West met with Sylvain Bouix to go over fibre tracking techniques and methods for analysis.<br /> * Got Sylvain's opinion on current 1.5 T data.<br /> * Discussed with Sylvain, Marty Shenton and others on potential collaborative papers (e.g. cingulate bundle in schizophrenics vs. controls)<br /> * Shared some 3T Philips DTI data with Sylvain to compare with Harvard's current 3T GE data.</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:FractionalAnisotrophyInTheUncinateFasciculus&diff=9499 2007-04-20T17:47:05Z

<p>Jdwest: </p> <hr /> <div> Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]<br /> <br /> '''Objective:''' To measure the FA in the uncinate fasciculus in patients with schizophrenia. This project is based on the methods published by Kubicki et al. and extends that work by including a bipolar disorder control group, and determining whether there is an association between FA and cognitive functioning and symptoms in the patient groups.<br /> <br /> '''Progress:''' DTI data has been collected in 12 patients with schizophrenia, 15 healthy controls and 8 patients with bipolar disorder. Initial practice at identifying coronal slice of uncinate fasciculus completed (see figure below for example). Visit to Dartmouth by Dr. Kubicki to discuss methodology. A link to sample DTI data is available below.<br /> <br /> [[Image:NAMIC_UncinateFasiculus_prelim.jpg|[[Image:NAMIC_UncinateFasiculus_prelim.jpg|Image:NAMIC_UncinateFasiculus_prelim.jpg]]]]<br /> <br /> '''Progress from AHM 2007:''' Training on fiber tractography in Slicer with Sylvain Bouix that we can apply to this project as well as investigation of other fibre tracts such as the cingulate bundle.<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Heather Pixley, Robert Roth, Laura Flashman, Andrew Saykin, John West<br /> * Harvard: Marek Kubicki<br /> <br /> '''Links'''<br /> <br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * Sample Data: https://portal.nbirn.net/BIRN/cgi-bin/DataGrid/browse.cgi?browseloc=/home/Projects/NAMIC__0003/Files/Dartmouth/HealthyControls6</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:Dartmouth&diff=9498 2007-04-20T17:45:04Z

<p>Jdwest: /* Events */</p> <hr /> <div>== IRB Information ==<br /> <br /> NA-MIC data is overseen by both the Dartmouth CPHS and the NH State IRB. We have received approval from each entity to share deidentified data with NA-MIC researchers via the wiki. The link between shared data and private subject IDs is kept at Dartmouth in a locked cabinet, within a locked office, and outside researchers will not have access to this information. Data is not to be shared with researchers outside the NA-MIC consortium.<br /> <br /> == Data Access ==<br /> <br /> A More detailed description of the data sets can be found [[DataRepository|here]]. Data includes:<br /> <br /> * 6 Healthy Controls Data<br /> ** SPGR<br /> ** T2<br /> ** fMRI (ER-RECOG task)<br /> ** DTI<br /> ** Hippocampus Traces – from Brains<br /> ** Hippocampal ROIs – Binary ROIs<br /> * MRI Data for 15 SZ<br /> ** SPGR<br /> ** Frontal Traces: 8 Structures (right and left) – from Brains<br /> <br /> == Collaborations ==<br /> <br /> * Working with Steve Pieper and Gordon Kindlmann to correctly incorporate new 3T data into Slicer.<br /> ** Have uploaded sample data to BIRN to address diffusion direction concern and eddy current correction testing. These action items were developed during May 19th, 2006 visit by Steve Pieper and Ron Kikinis to Dartmouth.<br /> * Correspondence with Steve Pieper to help debug Slicer 2.6 for 64-bit Linux.<br /> * Collaboration with Josh Snyder/David Tuch at Harvard on DTI Path of Interest Project.<br /> * Correspondence with Josh Snyder/Xiaodong Tao to help create script to convert Dartmouth data to nrrd format.<br /> * Collaboration with team at Harvard and Steve Pieper to help improve and get training on Slicer Editor, DTI-MRI module, and fMRI module.<br /> * Collaboration with Shenton Lab to port Dartmouth fMRI tasks to Harvard site for local (Boston) data collection.<br /> <br /> == Events ==<br /> <br /> * [[DBP:AHM_2007_progress|Progress report from January 2007 AHM in Salt Lake City]]<br /> * [[Slicer:StevePieper_RonKikinis_VisitToDartmouth_051906|May 19, 2006: Steve Pieper and Ron Kikinis Visit to Dartmouth]]<br /> * [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]<br /> * [[DBP:Brain_Imaging_Lab_Review_AHM|January 20 2006: Review of AHM for Dartmouth lab]]<br /> * [[AHM_2006:AHM_2006|January 8-13, 2006: The Second All-Hands-Meeting and Programming Event in Salt Lake City, Utah]]<br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]<br /> * [[Dissemination:Workshop_May_26-27_2005|May 26-27, 2005. User Training and Dissemination Workshop at Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_April_21_2005|April 21-22, 2005: Andy Saykin visit to Brigham and Women's Hospital and MIT]]<br /> * [[AHM_2005:Main|February 20-22, 2005 AHM in SLC]]<br /> <br /> == Ongoing NA-MIC Projects ==<br /> <br /> '''Structural Projects'''<br /> <br /> * Morphometry of medial temporal lobe structures in schizophrenia<br /> <br /> '''DTI Projects'''<br /> <br /> * Corpus Callosum Fiber Tractography in schizophrenia<br /> * Fractional anisotrophy in the uncinate fasciculus in schizophrenia and bipolar I disorder (replication and extension of Kubicki study)<br /> * Intergity of fronto-temporal circuitry in schizophrenia using path of interest analysis<br /> <br /> '''fMRI Projects'''<br /> <br /> * Neural substrates of working memory in schizophrenia: A parametric 3-Back study<br /> * Brain activation during a continuous verbal encoding and recognition task in schizophrenia<br /> * Fronto-temporal connectivity in schizophrenia during semantic memory<br /> <br /> == Publications and Presentations (that have acknowledged NA-MIC) ==<br /> <br /> &lt;br /&gt;'''Peer Reviewed Journal Articles'''<br /> <br /> *Roth, R.M., Koven, N.S., Pendergrass, J.C., Flashman, L.A., &amp; Saykin, A.J. (submitted). Apathy and the processing of novelty in schizophrenia. Schizophrenia Research.<br /> <br /> *Koven, N.S., Roth, R.M., Pendergrass, J.C., Flashman, L.A., McAllister, T.W., &amp; Saykin, A.J. (submitted). Contribution of semantic clustering strategy to verbal learning and memory in schizophrenia. Journal of Clinical and Experimental Neuropsychology.<br /> <br /> * Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., &amp; Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging.<br /> <br /> * Roth, R.M., Saykin, A.J., Flashman, L.A., Pixley, H.S., West, J.D., Mamourian, A.C. (in press). Event-Related fMRI of Response Inhibition in Obsessive-Compulsive Disorder. Biological Psychiatry.<br /> <br /> * McHugh, T.L., Saykin, A.J., Wishart, H.A., Flashman, L.A., Cleavinger, H.B., Rabin, L.A., Mamourian, A.C., Shen, L. (in press). Hippocampal Volume and Shape Analysis in an Older Adult Population. The Clinical Neuropsychologist.<br /> <br /> * Wishart, H.A., Saykin, A.J., McAllister, T.W., Rabin, L.A., McDonald, B.C., Flashman, L.A., Roth, R.M., Mamourian, A.C., Tsongalis, G.J., Rhodes, C.H. (2006). Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele. Neurology. 67(5):834-42.<br /> <br /> * Saykin, A.J., Wishart, H.A., Rabin, L.A., Santulli, R.B., Flashman, L.A., West, J.D., McHugh, T.L., Mamourian, A.C. (2006). Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology. 67(7):1221-4.<br /> <br /> * Roth RM, Koven, NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. (2006). Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089. <br /> <br /> <br /> '''Abstracts and Conference Proceedings'''<br /> <br /> * West, J., Saykin, A., Roth, R., Flashman, L., Koven, N., Pendergrass, J.C., Arfanakis, K. (2007). Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers. Poster to be presented at the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago, June.<br /> <br /> *Flashman, L.A., Roth, R.M., McAllister, T.W., Pendergrass, J.C., Garlinghouse, M.A., &amp; Saykin, A.J. (2007). Dissociation of awareness of different components of illness in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February.<br /> <br /> *Koven, N.S., Roth, R.M., Buzzuto, L., Pendergrass, J.C., Flashman, L.A., &amp; Saykin, A.J. (2007). Impact of reaction time variability on brain activation during working memory in schizophrenia. Poster to be presented at the 35th Annual Meeting of the International Neuropsychological Society, Portland, February.<br /> <br /> *Roth, R.M., Flashman, L.A., Koven, N.S., Pendergrass, J.C., Garlinghouse, M.A.,* McAllister, T.W., &amp; Saykin, A.J. (2007). Subjective integrity of working memory is related to brain activation during an N-back task in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February.<br /> <br /> * Koven, N.S., Roth, R.M., Flashman, L.A., Randolph, J.J., Pixley, H.S., Ricketts, S.M., Wishart, H.A., &amp; Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230.<br /> <br /> * Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., &amp; Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:FractionalAnisotrophyInTheUncinateFasciculus&diff=9497 2007-04-20T17:43:11Z

<p>Jdwest: </p> <hr /> <div> Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]<br /> <br /> '''Objective:''' To measure the FA in the uncinate fasciculus in patients with schizophrenia. This project is based on the methods published by Kubicki et al. and extends that work by including a bipolar disorder control group, and determining whether there is an association between FA and cognitive functioning and symptoms in the patient groups.<br /> <br /> '''Progress:''' DTI data has been collected in 12 patients with schizophrenia, 15 healthy controls and 8 patients with bipolar disorder. Initial practice at identifying coronal slice of uncinate fasciculus completed (see figure below for example). Visit to Dartmouth by Dr. Kubicki to discuss methodology. A link to sample DTI data is available below.<br /> <br /> [[Image:NAMIC_UncinateFasiculus_prelim.jpg|[[Image:NAMIC_UncinateFasiculus_prelim.jpg|Image:NAMIC_UncinateFasiculus_prelim.jpg]]]]<br /> <br /> '''Progress from AHM 2007:''' Training on fiber tractography in Slicer with Sylvain Bioux that we can apply to this project as well as investigation of other fibre tracts such as the cingulate bundle.<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Heather Pixley, Robert Roth, Laura Flashman, Andrew Saykin, John West<br /> * Harvard: Marek Kubicki<br /> <br /> '''Links'''<br /> <br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * Sample Data: https://portal.nbirn.net/BIRN/cgi-bin/DataGrid/browse.cgi?browseloc=/home/Projects/NAMIC__0003/Files/Dartmouth/HealthyControls6</div>

Jdwest https://www.na-mic.org/w/index.php?title=Projects:IntegrityOfFrontoTemporalCircuitry&diff=9496 2007-04-20T17:41:08Z

<p>Jdwest: </p> <hr /> <div> Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]<br /> <br /> '''Objective:''' To develop methodology that will permit investigators to specify functional MRI regional of interests (fROI) and determine the optimal white matter pathways between the fROIs based on DTI.<br /> <br /> '''Progress:''' Working path of interest tool at Dartmouth that is currently being tested further. We've had success on mapping out uncinate fasciculus and arcuate fasciculus in a healthy adult. Next step will be to apply the methodology in a larger sample of subjects to verify reliability within and across subjects.<br /> <br /> '''Update from AHM 2007:''' John West had training session with Dennis Jen on new version of POI algorithm. Worked together to read new Dartmouth 3T Philips Data. Further work ongoing to integrate POI into Slicer 3.<br /> <br /> '''Key Investigators:'''<br /> <br /> * Dartmouth: Andrew Saykin, John West, Robert Roth, Laura Flashman<br /> * Harvard: Dennis Jen, Dave Tuch, Josh Snyder, Steve Pieper, Gordon Kindlmann<br /> <br /> '''Links:'''<br /> <br /> * [[AHM_2006:ProjectsDTIPathOfInterest|Path of Interest Algorithm Development]]</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:Dartmouth&diff=9412 2007-04-19T14:00:55Z

<p>Jdwest: /* Publications and Presentations (that have acknowledged NA-MIC) */</p> <hr /> <div>== IRB Information ==<br /> <br /> NA-MIC data is overseen by both the Dartmouth CPHS and the NH State IRB. We have received approval from each entity to share deidentified data with NA-MIC researchers via the wiki. The link between shared data and private subject IDs is kept at Dartmouth in a locked cabinet, within a locked office, and outside researchers will not have access to this information. Data is not to be shared with researchers outside the NA-MIC consortium.<br /> <br /> == Data Access ==<br /> <br /> A More detailed description of the data sets can be found [[DataRepository|here]]. Data includes:<br /> <br /> * 6 Healthy Controls Data<br /> ** SPGR<br /> ** T2<br /> ** fMRI (ER-RECOG task)<br /> ** DTI<br /> ** Hippocampus Traces – from Brains<br /> ** Hippocampal ROIs – Binary ROIs<br /> * MRI Data for 15 SZ<br /> ** SPGR<br /> ** Frontal Traces: 8 Structures (right and left) – from Brains<br /> <br /> == Collaborations ==<br /> <br /> * Working with Steve Pieper and Gordon Kindlmann to correctly incorporate new 3T data into Slicer.<br /> ** Have uploaded sample data to BIRN to address diffusion direction concern and eddy current correction testing. These action items were developed during May 19th, 2006 visit by Steve Pieper and Ron Kikinis to Dartmouth.<br /> * Correspondence with Steve Pieper to help debug Slicer 2.6 for 64-bit Linux.<br /> * Collaboration with Josh Snyder/David Tuch at Harvard on DTI Path of Interest Project.<br /> * Correspondence with Josh Snyder/Xiaodong Tao to help create script to convert Dartmouth data to nrrd format.<br /> * Collaboration with team at Harvard and Steve Pieper to help improve and get training on Slicer Editor, DTI-MRI module, and fMRI module.<br /> * Collaboration with Shenton Lab to port Dartmouth fMRI tasks to Harvard site for local (Boston) data collection.<br /> <br /> == Events ==<br /> <br /> * [[Slicer:StevePieper_RonKikinis_VisitToDartmouth_051906|May 19, 2006: Steve Pieper and Ron Kikinis Visit to Dartmouth]]<br /> * [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]<br /> * [[DBP:Brain_Imaging_Lab_Review_AHM|January 20 2006: Review of AHM for Dartmouth lab]]<br /> * [[AHM_2006:AHM_2006|January 8-13, 2006: The Second All-Hands-Meeting and Programming Event in Salt Lake City, Utah]]<br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]<br /> * [[Dissemination:Workshop_May_26-27_2005|May 26-27, 2005. User Training and Dissemination Workshop at Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_April_21_2005|April 21-22, 2005: Andy Saykin visit to Brigham and Women's Hospital and MIT]]<br /> * [[AHM_2005:Main|February 20-22, 2005 AHM in SLC]]<br /> <br /> == Ongoing NA-MIC Projects ==<br /> <br /> '''Structural Projects'''<br /> <br /> * Morphometry of medial temporal lobe structures in schizophrenia<br /> <br /> '''DTI Projects'''<br /> <br /> * Corpus Callosum Fiber Tractography in schizophrenia<br /> * Fractional anisotrophy in the uncinate fasciculus in schizophrenia and bipolar I disorder (replication and extension of Kubicki study)<br /> * Intergity of fronto-temporal circuitry in schizophrenia using path of interest analysis<br /> <br /> '''fMRI Projects'''<br /> <br /> * Neural substrates of working memory in schizophrenia: A parametric 3-Back study<br /> * Brain activation during a continuous verbal encoding and recognition task in schizophrenia<br /> * Fronto-temporal connectivity in schizophrenia during semantic memory<br /> <br /> == Publications and Presentations (that have acknowledged NA-MIC) ==<br /> <br /> &lt;br /&gt;'''Peer Reviewed Journal Articles'''<br /> <br /> *Roth, R.M., Koven, N.S., Pendergrass, J.C., Flashman, L.A., &amp; Saykin, A.J. (submitted). Apathy and the processing of novelty in schizophrenia. Schizophrenia Research.<br /> <br /> *Koven, N.S., Roth, R.M., Pendergrass, J.C., Flashman, L.A., McAllister, T.W., &amp; Saykin, A.J. (submitted). Contribution of semantic clustering strategy to verbal learning and memory in schizophrenia. Journal of Clinical and Experimental Neuropsychology.<br /> <br /> * Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., &amp; Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging.<br /> <br /> * Roth, R.M., Saykin, A.J., Flashman, L.A., Pixley, H.S., West, J.D., Mamourian, A.C. (in press). Event-Related fMRI of Response Inhibition in Obsessive-Compulsive Disorder. Biological Psychiatry.<br /> <br /> * McHugh, T.L., Saykin, A.J., Wishart, H.A., Flashman, L.A., Cleavinger, H.B., Rabin, L.A., Mamourian, A.C., Shen, L. (in press). Hippocampal Volume and Shape Analysis in an Older Adult Population. The Clinical Neuropsychologist.<br /> <br /> * Wishart, H.A., Saykin, A.J., McAllister, T.W., Rabin, L.A., McDonald, B.C., Flashman, L.A., Roth, R.M., Mamourian, A.C., Tsongalis, G.J., Rhodes, C.H. (2006). Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele. Neurology. 67(5):834-42.<br /> <br /> * Saykin, A.J., Wishart, H.A., Rabin, L.A., Santulli, R.B., Flashman, L.A., West, J.D., McHugh, T.L., Mamourian, A.C. (2006). Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology. 67(7):1221-4.<br /> <br /> * Roth RM, Koven, NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. (2006). Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089. <br /> <br /> <br /> '''Abstracts and Conference Proceedings'''<br /> <br /> * West, J., Saykin, A., Roth, R., Flashman, L., Koven, N., Pendergrass, J.C., Arfanakis, K. (2007). Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers. Poster to be presented at the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago, June.<br /> <br /> *Flashman, L.A., Roth, R.M., McAllister, T.W., Pendergrass, J.C., Garlinghouse, M.A., &amp; Saykin, A.J. (2007). Dissociation of awareness of different components of illness in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February.<br /> <br /> *Koven, N.S., Roth, R.M., Buzzuto, L., Pendergrass, J.C., Flashman, L.A., &amp; Saykin, A.J. (2007). Impact of reaction time variability on brain activation during working memory in schizophrenia. Poster to be presented at the 35th Annual Meeting of the International Neuropsychological Society, Portland, February.<br /> <br /> *Roth, R.M., Flashman, L.A., Koven, N.S., Pendergrass, J.C., Garlinghouse, M.A.,* McAllister, T.W., &amp; Saykin, A.J. (2007). Subjective integrity of working memory is related to brain activation during an N-back task in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February.<br /> <br /> * Koven, N.S., Roth, R.M., Flashman, L.A., Randolph, J.J., Pixley, H.S., Ricketts, S.M., Wishart, H.A., &amp; Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230.<br /> <br /> * Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., &amp; Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:Dartmouth&diff=7070 2007-01-19T20:31:44Z

<p>Jdwest: /* Publications and Presentations (that have acknowledged NA-MIC) */</p> <hr /> <div>== IRB Information ==<br /> <br /> NA-MIC data is overseen by both the Dartmouth CPHS and the NH State IRB. We have received approval from each entity to share deidentified data with NA-MIC researchers via the wiki. The link between shared data and private subject IDs is kept at Dartmouth in a locked cabinet, within a locked office, and outside researchers will not have access to this information. Data is not to be shared with researchers outside the NA-MIC consortium.<br /> <br /> == Data Access ==<br /> <br /> A More detailed description of the data sets can be found [[DataRepository|here]]. Data includes:<br /> <br /> * 6 Healthy Controls Data<br /> ** SPGR<br /> ** T2<br /> ** fMRI (ER-RECOG task)<br /> ** DTI<br /> ** Hippocampus Traces – from Brains<br /> ** Hippocampal ROIs – Binary ROIs<br /> * MRI Data for 15 SZ<br /> ** SPGR<br /> ** Frontal Traces: 8 Structures (right and left) – from Brains<br /> <br /> == Collaborations ==<br /> <br /> * Working with Steve Pieper and Gordon Kindlmann to correctly incorporate new 3T data into Slicer.<br /> ** Have uploaded sample data to BIRN to address diffusion direction concern and eddy current correction testing. These action items were developed during May 19th, 2006 visit by Steve Pieper and Ron Kikinis to Dartmouth.<br /> * Correspondence with Steve Pieper to help debug Slicer 2.6 for 64-bit Linux.<br /> * Collaboration with Josh Snyder/David Tuch at Harvard on DTI Path of Interest Project.<br /> * Correspondence with Josh Snyder/Xiaodong Tao to help create script to convert Dartmouth data to nrrd format.<br /> * Collaboration with team at Harvard and Steve Pieper to help improve and get training on Slicer Editor, DTI-MRI module, and fMRI module.<br /> * Collaboration with Shenton Lab to port Dartmouth fMRI tasks to Harvard site for local (Boston) data collection.<br /> <br /> == Events ==<br /> <br /> * [[Slicer:StevePieper_RonKikinis_VisitToDartmouth_051906|May 19, 2006: Steve Pieper and Ron Kikinis Visit to Dartmouth]]<br /> * [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]<br /> * [[DBP:Brain_Imaging_Lab_Review_AHM|January 20 2006: Review of AHM for Dartmouth lab]]<br /> * [[AHM_2006:AHM_2006|January 8-13, 2006: The Second All-Hands-Meeting and Programming Event in Salt Lake City, Utah]]<br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]<br /> * [[Dissemination:Workshop_May_26-27_2005|May 26-27, 2005. User Training and Dissemination Workshop at Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_April_21_2005|April 21-22, 2005: Andy Saykin visit to Brigham and Women's Hospital and MIT]]<br /> * [[AHM_2005:Main|February 20-22, 2005 AHM in SLC]]<br /> <br /> == Ongoing NA-MIC Projects ==<br /> <br /> '''Structural Projects'''<br /> <br /> * Morphometry of medial temporal lobe structures in schizophrenia<br /> <br /> '''DTI Projects'''<br /> <br /> * Corpus Callosum Fiber Tractography in schizophrenia<br /> * Fractional anisotrophy in the uncinate fasciculus in schizophrenia and bipolar I disorder (replication and extension of Kubicki study)<br /> * Intergity of fronto-temporal circuitry in schizophrenia using path of interest analysis<br /> <br /> '''fMRI Projects'''<br /> <br /> * Neural substrates of working memory in schizophrenia: A parametric 3-Back study<br /> * Brain activation during a continuous verbal encoding and recognition task in schizophrenia<br /> * Fronto-temporal connectivity in schizophrenia during semantic memory<br /> <br /> == Publications and Presentations (that have acknowledged NA-MIC) ==<br /> <br /> &lt;br /&gt;'''Peer Reviewed Journal Articles'''<br /> <br /> *Roth, R.M., Koven, N.S., Pendergrass, J.C., Flashman, L.A., &amp; Saykin, A.J. (submitted). Apathy and the processing of novelty in schizophrenia. Schizophrenia Research.<br /> <br /> *Koven, N.S., Roth, R.M., Pendergrass, J.C., Flashman, L.A., McAllister, T.W., &amp; Saykin, A.J. (submitted). Contribution of semantic clustering strategy to verbal learning and memory in schizophrenia. Journal of Clinical and Experimental Neuropsychology.<br /> <br /> * Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., &amp; Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging.<br /> <br /> * Roth, R.M., Saykin, A.J., Flashman, L.A., Pixley, H.S., West, J.D., Mamourian, A.C. (in press). Event-Related fMRI of Response Inhibition in Obsessive-Compulsive Disorder. Biological Psychiatry.<br /> <br /> * McHugh, T.L., Saykin, A.J., Wishart, H.A., Flashman, L.A., Cleavinger, H.B., Rabin, L.A., Mamourian, A.C., Shen, L. (in press). Hippocampal Volume and Shape Analysis in an Older Adult Population. The Clinical Neuropsychologist.<br /> <br /> * Wishart, H.A., Saykin, A.J., McAllister, T.W., Rabin, L.A., McDonald, B.C., Flashman, L.A., Roth, R.M., Mamourian, A.C., Tsongalis, G.J., Rhodes, C.H. (2006). Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele. Neurology. 67(5):834-42.<br /> <br /> * Saykin, A.J., Wishart, H.A., Rabin, L.A., Santulli, R.B., Flashman, L.A., West, J.D., McHugh, T.L., Mamourian, A.C. (2006). Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology. 67(7):1221-4.<br /> <br /> * Roth RM, Koven, NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. (2006). Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089. <br /> <br /> <br /> '''Abstracts and Conference Proceedings'''<br /> <br /> * West, J., Saykin, A., Roth, R., Flashman, L., Koven, N., Pendergrass, J.C., Arfanakis, K. (2007). Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers. Submitted to the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago, June.<br /> <br /> *Flashman, L.A., Roth, R.M., McAllister, T.W., Pendergrass, J.C., Garlinghouse, M.A., &amp; Saykin, A.J. (2007). Dissociation of awareness of different components of illness in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February.<br /> <br /> *Koven, N.S., Roth, R.M., Buzzuto, L., Pendergrass, J.C., Flashman, L.A., &amp; Saykin, A.J. (2007). Impact of reaction time variability on brain activation during working memory in schizophrenia. Poster to be presented at the 35th Annual Meeting of the International Neuropsychological Society, Portland, February.<br /> <br /> *Roth, R.M., Flashman, L.A., Koven, N.S., Pendergrass, J.C., Garlinghouse, M.A.,* McAllister, T.W., &amp; Saykin, A.J. (2007). Subjective integrity of working memory is related to brain activation during an N-back task in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February.<br /> <br /> * Koven, N.S., Roth, R.M., Flashman, L.A., Randolph, J.J., Pixley, H.S., Ricketts, S.M., Wishart, H.A., &amp; Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230.<br /> <br /> * Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., &amp; Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:Dartmouth&diff=6284 2007-01-09T18:35:07Z

<p>Jdwest: /* Publications and Presentations (that have acknowledged NA-MIC) */</p> <hr /> <div>== IRB Information ==<br /> <br /> NA-MIC data is overseen by both the Dartmouth CPHS and the NH State IRB. We have received approval from each entity to share deidentified data with NA-MIC researchers via the wiki. The link between shared data and private subject IDs is kept at Dartmouth in a locked cabinet, within a locked office, and outside researchers will not have access to this information. Data is not to be shared with researchers outside the NA-MIC consortium.<br /> <br /> == Data Access ==<br /> <br /> A More detailed description of the data sets can be found [[DataRepository|here]]. Data includes:<br /> <br /> * 6 Healthy Controls Data<br /> ** SPGR<br /> ** T2<br /> ** fMRI (ER-RECOG task)<br /> ** DTI<br /> ** Hippocampus Traces – from Brains<br /> ** Hippocampal ROIs – Binary ROIs<br /> * MRI Data for 15 SZ<br /> ** SPGR<br /> ** Frontal Traces: 8 Structures (right and left) – from Brains<br /> <br /> == Collaborations ==<br /> <br /> * Working with Steve Pieper and Gordon Kindlmann to correctly incorporate new 3T data into Slicer.<br /> ** Have uploaded sample data to BIRN to address diffusion direction concern and eddy current correction testing. These action items were developed during May 19th, 2006 visit by Steve Pieper and Ron Kikinis to Dartmouth.<br /> * Correspondence with Steve Pieper to help debug Slicer 2.6 for 64-bit Linux.<br /> * Collaboration with Josh Snyder/David Tuch at Harvard on DTI Path of Interest Project.<br /> * Correspondence with Josh Snyder/Xiaodong Tao to help create script to convert Dartmouth data to nrrd format.<br /> * Collaboration with team at Harvard and Steve Pieper to help improve and get training on Slicer Editor, DTI-MRI module, and fMRI module.<br /> * Collaboration with Shenton Lab to port Dartmouth fMRI tasks to Harvard site for local (Boston) data collection.<br /> <br /> == Events ==<br /> <br /> * [[Slicer:StevePieper_RonKikinis_VisitToDartmouth_051906|May 19, 2006: Steve Pieper and Ron Kikinis Visit to Dartmouth]]<br /> * [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]<br /> * [[DBP:Brain_Imaging_Lab_Review_AHM|January 20 2006: Review of AHM for Dartmouth lab]]<br /> * [[AHM_2006:AHM_2006|January 8-13, 2006: The Second All-Hands-Meeting and Programming Event in Salt Lake City, Utah]]<br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]<br /> * [[Dissemination:Workshop_May_26-27_2005|May 26-27, 2005. User Training and Dissemination Workshop at Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_April_21_2005|April 21-22, 2005: Andy Saykin visit to Brigham and Women's Hospital and MIT]]<br /> * [[AHM_2005:Main|February 20-22, 2005 AHM in SLC]]<br /> <br /> == Ongoing NA-MIC Projects ==<br /> <br /> '''Structural Projects'''<br /> <br /> * Morphometry of medial temporal lobe structures in schizophrenia<br /> <br /> '''DTI Projects'''<br /> <br /> * Corpus Callosum Fiber Tractography in schizophrenia<br /> * Fractional anisotrophy in the uncinate fasciculus in schizophrenia and bipolar I disorder (replication and extension of Kubicki study)<br /> * Intergity of fronto-temporal circuitry in schizophrenia using path of interest analysis<br /> <br /> '''fMRI Projects'''<br /> <br /> * Neural substrates of working memory in schizophrenia: A parametric 3-Back study<br /> * Brain activation during a continuous verbal encoding and recognition task in schizophrenia<br /> * Fronto-temporal connectivity in schizophrenia during semantic memory<br /> <br /> == Publications and Presentations (that have acknowledged NA-MIC) ==<br /> <br /> &lt;br /&gt;'''Peer Reviewed Journal Articles'''<br /> <br /> *Roth, R.M., Koven, N.S., Pendergrass, J.C., Flashman, L.A., &amp; Saykin, A.J. (submitted). Apathy and the processing of novelty in schizophrenia. Schizophrenia Research.<br /> <br /> *Koven, N.S., Roth, R.M., Pendergrass, J.C., Flashman, L.A., McAllister, T.W., &amp; Saykin, A.J. (submitted). Contribution of semantic clustering strategy to verbal learning and memory in schizophrenia. Journal of Clinical and Experimental Neuropsychology.<br /> <br /> * Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., &amp; Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging.<br /> <br /> * Roth, R.M., Saykin, A.J., Flashman, L.A., Pixley, H.S., West, J.D., Mamourian, A.C. (in press). Event-Related fMRI of Response Inhibition in Obsessive-Compulsive Disorder. Biological Psychiatry.<br /> <br /> * McHugh, T.L., Saykin, A.J., Wishart, H.A., Flashman, L.A., Cleavinger, H.B., Rabin, L.A., Mamourian, A.C., Shen, L. (in press). Hippocampal Volume and Shape Analysis in an Older Adult Population. The Clinical Neuropsychologist.<br /> <br /> * Wishart, H.A., Saykin, A.J., McAllister, T.W., Rabin, L.A., McDonald, B.C., Flashman, L.A., Roth, R.M., Mamourian, A.C., Tsongalis, G.J., Rhodes, C.H. (2006). Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele. Neurology. 67(5):834-42.<br /> <br /> * Saykin, A.J., Wishart, H.A., Rabin, L.A., Santulli, R.B., Flashman, L.A., West, J.D., McHugh, T.L., Mamourian, A.C. (2006). Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology. 67(7):1221-4.<br /> <br /> * Roth RM, Koven, NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. (2006). Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089. <br /> <br /> <br /> '''Abstracts and Conference Proceedings'''<br /> <br /> * West, J., Saykin, A., Roth, R., Flashman, L., Koven, N., Pendergrass, J.C., Arfanakis, K. (2007). Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers. Submitted to the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago, June.<br /> <br /> *Flashman, L.A., Roth, R.M., McAllister, T.W., Pendergrass, J.C., Garlinghouse, M.A., &amp; Saykin, A.J. (2007). Dissociation of awareness of different components of illness in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February.<br /> <br /> *Koven, N.S., Roth, R.M., Buzzuto, L., Pendergrass, J.C., Flashman, L.A., &amp; Saykin, A.J. (2007). Impact of reaction time variability on brain activation during working memory in schizophrenia. Poster to be presented at the 35th Annual Meeting of the International Neuropsychological Society, Portland, February.<br /> <br /> *Roth, R.M., Flashman, L.A., Koven, N.S., Pendergrass, J.C., Garlinghouse, M.A.,* McAllister, T.W., &amp; Saykin, A.J. (2007). Subjective integrity of working memory is related to brain activation during an N-back task in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February.<br /> <br /> * Koven, N.S., Roth, R.M., Flashman, L.A., Randolph, J.J., Pixley, H.S., Ricketts, S.M., Wishart, H.A., &amp; Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230.<br /> <br /> * Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., &amp; Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.<br /> <br /> <br /> '''Presentations'''<br /> <br /> * 11/03/06 Executive functions across the lifespan: Conceptualization and assessment (Robert M. Roth, Ph.D &amp; Peter Isquith, Ph.D.). CE course sponsored by the Massachusetts Psychological Association.<br /> <br /> * 09/29/06 Executive functions across the lifespan: Conceptualization and assessment (Robert M. Roth, Ph.D &amp; Peter Isquith, Ph.D.). CE course sponsored by the New Hampshire Psychological Association, Concord, NH.<br /> <br /> * 08/23/06 Clinical neuroscience of the child and adolescent brain. CE course sponsored by the Heath Care and Rehabilitation Services of Southeastern Vermont, Bellows Falls, VT. (Robert M. Roth, Ph.D)* 05/11/06 Robert M. Roth, Ph.D. The brain in obsessive-compulsive disorder: From Freud to fMRI. Colloquium lecture, Department of Psychology, Brooklyn College, New York.<br /> <br /> * 01/31/06 Robert M. Roth, Ph.D. Thinking again about the brain in obsessive-compulsive disorder. Grand rounds, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH.<br /> <br /> * 12/06/05 Robert M. Roth, Ph.D. Advances in the neuroimaging of obsessive-compulsive disorder. Invited continuing medical education lecture at Dartmouth College Health Services, Hanover, NH.<br /> <br /> * 12/02/05 Robert M. Roth, Ph.D. Neuroimaging of frontal-subcortical circuitry in obsessive- compulsive disorder. Invited lecture at the Centre de Recherche Fernand Seguin, Montreal.<br /> <br /> * 11/12/05 Robert M. Roth, Ph.D. OCD and the brain: Imaging symptoms and cognition. Invited lecture at the 3rd Annual Meeting of the Quebec Obsessive Compulsive Foundation, Montreal.</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:Dartmouth&diff=6077 2007-01-08T20:33:26Z

<p>Jdwest: /* Publications and Presentations (that have acknowledged NA-MIC) */</p> <hr /> <div>== IRB Information ==<br /> <br /> NA-MIC data is overseen by both the Dartmouth CPHS and the NH State IRB. We have received approval from each entity to share deidentified data with NA-MIC researchers via the wiki. The link between shared data and private subject IDs is kept at Dartmouth in a locked cabinet, within a locked office, and outside researchers will not have access to this information. Data is not to be shared with researchers outside the NA-MIC consortium.<br /> <br /> == Data Access ==<br /> <br /> A More detailed description of the data sets can be found [[DataRepository|here]]. Data includes:<br /> <br /> * 6 Healthy Controls Data<br /> ** SPGR<br /> ** T2<br /> ** fMRI (ER-RECOG task)<br /> ** DTI<br /> ** Hippocampus Traces – from Brains<br /> ** Hippocampal ROIs – Binary ROIs<br /> * MRI Data for 15 SZ<br /> ** SPGR<br /> ** Frontal Traces: 8 Structures (right and left) – from Brains<br /> <br /> == Collaborations ==<br /> <br /> * Working with Steve Pieper and Gordon Kindlmann to correctly incorporate new 3T data into Slicer.<br /> ** Have uploaded sample data to BIRN to address diffusion direction concern and eddy current correction testing. These action items were developed during May 19th, 2006 visit by Steve Pieper and Ron Kikinis to Dartmouth.<br /> * Correspondence with Steve Pieper to help debug Slicer 2.6 for 64-bit Linux.<br /> * Collaboration with Josh Snyder/David Tuch at Harvard on DTI Path of Interest Project.<br /> * Correspondence with Josh Snyder/Xiaodong Tao to help create script to convert Dartmouth data to nrrd format.<br /> * Collaboration with team at Harvard and Steve Pieper to help improve and get training on Slicer Editor, DTI-MRI module, and fMRI module.<br /> * Collaboration with Shenton Lab to port Dartmouth fMRI tasks to Harvard site for local (Boston) data collection.<br /> <br /> == Events ==<br /> <br /> * [[Slicer:StevePieper_RonKikinis_VisitToDartmouth_051906|May 19, 2006: Steve Pieper and Ron Kikinis Visit to Dartmouth]]<br /> * [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]<br /> * [[DBP:Brain_Imaging_Lab_Review_AHM|January 20 2006: Review of AHM for Dartmouth lab]]<br /> * [[AHM_2006:AHM_2006|January 8-13, 2006: The Second All-Hands-Meeting and Programming Event in Salt Lake City, Utah]]<br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]<br /> * [[Dissemination:Workshop_May_26-27_2005|May 26-27, 2005. User Training and Dissemination Workshop at Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_April_21_2005|April 21-22, 2005: Andy Saykin visit to Brigham and Women's Hospital and MIT]]<br /> * [[AHM_2005:Main|February 20-22, 2005 AHM in SLC]]<br /> <br /> == Ongoing NA-MIC Projects ==<br /> <br /> '''Structural Projects'''<br /> <br /> * Morphometry of medial temporal lobe structures in schizophrenia<br /> <br /> '''DTI Projects'''<br /> <br /> * Corpus Callosum Fiber Tractography in schizophrenia<br /> * Fractional anisotrophy in the uncinate fasciculus in schizophrenia and bipolar I disorder (replication and extension of Kubicki study)<br /> * Intergity of fronto-temporal circuitry in schizophrenia using path of interest analysis<br /> <br /> '''fMRI Projects'''<br /> <br /> * Neural substrates of working memory in schizophrenia: A parametric 3-Back study<br /> * Brain activation during a continuous verbal encoding and recognition task in schizophrenia<br /> * Fronto-temporal connectivity in schizophrenia during semantic memory<br /> <br /> == Publications and Presentations (that have acknowledged NA-MIC) ==<br /> <br /> &lt;br /&gt;'''Peer Reviewed Journal Articles'''<br /> <br /> * Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., &amp; Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging<br /> <br /> * Roth, R.M., Saykin, A.J., Flashman, L.A., Pixley, H.S., West, J.D., Mamourian, A.C. (in press). Event-Related fMRI of Response Inhibition in Obsessive-Compulsive Disorder. Biological Psychiatry.<br /> <br /> * McHugh, T.L., Saykin, A.J., Wishart, H.A., Flashman, L.A., Cleavinger, H.B., Rabin, L.A., Mamourian, A.C., Shen, L. (in press). Hippocampal Volume and Shape Analysis in an Older Adult Population. The Clinical Neuropsychologist.<br /> <br /> * Wishart, H.A., Saykin, A.J., McAllister, T.W., Rabin, L.A., McDonald, B.C., Flashman, L.A., Roth, R.M., Mamourian, A.C., Tsongalis, G.J., Rhodes, C.H. Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele. Neurology. 67(5):834-42, Sept. 12, 2006.<br /> <br /> * Saykin, A.J., Wishart, H.A., Rabin, L.A., Santulli, R.B., Flashman, L.A., West, J.D., McHugh, T.L., Mamourian, A.C. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology. 67(7):1221-4, Oct. 10, 2006.<br /> <br /> * Roth RM, Koven, NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089, July 31, 2006. <br /> <br /> '''Abstracts and Conference Proceedings'''<br /> <br /> * West, J., Saykin, A., Roth, R., Flashman, L., Koven, N., Pendergrass, J.C., Arfanakis, K. (2007). Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers. To be presented at the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago, June.<br /> <br /> * Koven, N.S., Roth, R.M., Flashman, L.A., Randolph, J.J., Pixley, H.S., Ricketts, S.M., Wishart, H.A., &amp; Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230.<br /> <br /> * Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., &amp; Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.<br /> <br /> '''Presentations'''<br /> <br /> * 05/11/06 Robert M. Roth, Ph.D. The brain in obsessive-compulsive disorder: From Freud to fMRI. Colloquium lecture, Department of Psychology, Brooklyn College, New York.<br /> <br /> * 01/31/06 Robert M. Roth, Ph.D. Thinking again about the brain in obsessive-compulsive disorder. Grand rounds, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH.<br /> <br /> * 12/06/05 Robert M. Roth, Ph.D. Advances in the neuroimaging of obsessive-compulsive disorder. Invited continuing medical education lecture at Dartmouth College Health Services, Hanover, New Hampshire.<br /> <br /> * 12/02/05 Robert M. Roth, Ph.D. Neuroimaging of frontal-subcortical circuitry in obsessive- compulsive disorder. Invited lecture at the Centre de Recherche Fernand Seguin, Montreal.<br /> <br /> * 11/12/05 Robert M. Roth, Ph.D. OCD and the brain: Imaging symptoms and cognition. Invited lecture at the 3rd Annual Meeting of the Quebec Obsessive Compulsive Foundation, Montreal.</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:Dartmouth&diff=6037 2007-01-08T17:00:07Z

<p>Jdwest: /* Publications and Presentations (that have used NA-MIC Tools) */</p> <hr /> <div>== IRB Information ==<br /> <br /> NA-MIC data is overseen by both the Dartmouth CPHS and the NH State IRB. We have received approval from each entity to share deidentified data with NA-MIC researchers via the wiki. The link between shared data and private subject IDs is kept at Dartmouth in a locked cabinet, within a locked office, and outside researchers will not have access to this information. Data is not to be shared with researchers outside the NA-MIC consortium.<br /> <br /> == Data Access ==<br /> <br /> A More detailed description of the data sets can be found [[DataRepository|here]]. Data includes:<br /> <br /> * 6 Healthy Controls Data<br /> ** SPGR<br /> ** T2<br /> ** fMRI (ER-RECOG task)<br /> ** DTI<br /> ** Hippocampus Traces – from Brains<br /> ** Hippocampal ROIs – Binary ROIs<br /> * MRI Data for 15 SZ<br /> ** SPGR<br /> ** Frontal Traces: 8 Structures (right and left) – from Brains<br /> <br /> == Collaborations ==<br /> <br /> * Working with Steve Pieper and Gordon Kindlmann to correctly incorporate new 3T data into Slicer.<br /> ** Have uploaded sample data to BIRN to address diffusion direction concern and eddy current correction testing. These action items were developed during May 19th, 2006 visit by Steve Pieper and Ron Kikinis to Dartmouth.<br /> * Correspondence with Steve Pieper to help debug Slicer 2.6 for 64-bit Linux.<br /> * Collaboration with Josh Snyder/David Tuch at Harvard on DTI Path of Interest Project.<br /> * Correspondence with Josh Snyder/Xiaodong Tao to help create script to convert Dartmouth data to nrrd format.<br /> * Collaboration with team at Harvard and Steve Pieper to help improve and get training on Slicer Editor, DTI-MRI module, and fMRI module.<br /> * Collaboration with Shenton Lab to port Dartmouth fMRI tasks to Harvard site for local (Boston) data collection.<br /> <br /> == Events ==<br /> <br /> * [[Slicer:StevePieper_RonKikinis_VisitToDartmouth_051906|May 19, 2006: Steve Pieper and Ron Kikinis Visit to Dartmouth]]<br /> * [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]<br /> * [[DBP:Brain_Imaging_Lab_Review_AHM|January 20 2006: Review of AHM for Dartmouth lab]]<br /> * [[AHM_2006:AHM_2006|January 8-13, 2006: The Second All-Hands-Meeting and Programming Event in Salt Lake City, Utah]]<br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]<br /> * [[Dissemination:Workshop_May_26-27_2005|May 26-27, 2005. User Training and Dissemination Workshop at Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_April_21_2005|April 21-22, 2005: Andy Saykin visit to Brigham and Women's Hospital and MIT]]<br /> * [[AHM_2005:Main|February 20-22, 2005 AHM in SLC]]<br /> <br /> == Ongoing NA-MIC Projects ==<br /> <br /> '''Structural Projects'''<br /> <br /> * Morphometry of medial temporal lobe structures in schizophrenia<br /> <br /> '''DTI Projects'''<br /> <br /> * Corpus Callosum Fiber Tractography in schizophrenia<br /> * Fractional anisotrophy in the uncinate fasciculus in schizophrenia and bipolar I disorder (replication and extension of Kubicki study)<br /> * Intergity of fronto-temporal circuitry in schizophrenia using path of interest analysis<br /> <br /> '''fMRI Projects'''<br /> <br /> * Neural substrates of working memory in schizophrenia: A parametric 3-Back study<br /> * Brain activation during a continuous verbal encoding and recognition task in schizophrenia<br /> * Fronto-temporal connectivity in schizophrenia during semantic memory<br /> <br /> == Publications and Presentations (that have acknowledged NA-MIC) ==<br /> <br /> &lt;br /&gt;'''Peer Reviewed Journal Articles'''<br /> <br /> * Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., &amp; Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging<br /> <br /> * Roth RM, Koven, NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089, July 31, 2006. <br /> <br /> '''Abstracts and Conference Proceedings'''<br /> <br /> * West, J., Saykin, A., Roth, R., Flashman, L., Koven, N., Pendergrass, J.C., Arfanakis, K. (2007). Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers. To be presented at the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago, June.<br /> <br /> * Koven, N.S., Roth, R.M., Flashman, L.A., Randolph, J.J., Pixley, H.S., Ricketts, S.M., Wishart, H.A., &amp; Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230.<br /> <br /> * Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., &amp; Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.<br /> <br /> '''Presentations'''<br /> <br /> * 05/11/06 Robert M. Roth, Ph.D. The brain in obsessive-compulsive disorder: From Freud to fMRI. Colloquium lecture, Department of Psychology, Brooklyn College, New York.<br /> <br /> * 01/31/06 Robert M. Roth, Ph.D. Thinking again about the brain in obsessive-compulsive disorder. Grand rounds, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH.<br /> <br /> * 12/06/05 Robert M. Roth, Ph.D. Advances in the neuroimaging of obsessive-compulsive disorder. Invited continuing medical education lecture at Dartmouth College Health Services, Hanover, New Hampshire.<br /> <br /> * 12/02/05 Robert M. Roth, Ph.D. Neuroimaging of frontal-subcortical circuitry in obsessive- compulsive disorder. Invited lecture at the Centre de Recherche Fernand Seguin, Montreal.<br /> <br /> * 11/12/05 Robert M. Roth, Ph.D. OCD and the brain: Imaging symptoms and cognition. Invited lecture at the 3rd Annual Meeting of the Quebec Obsessive Compulsive Foundation, Montreal.</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:Dartmouth&diff=6036 2007-01-08T16:59:36Z

<p>Jdwest: /* Publications and Presentations (that have used NA-MIC Tools) */</p> <hr /> <div>== IRB Information ==<br /> <br /> NA-MIC data is overseen by both the Dartmouth CPHS and the NH State IRB. We have received approval from each entity to share deidentified data with NA-MIC researchers via the wiki. The link between shared data and private subject IDs is kept at Dartmouth in a locked cabinet, within a locked office, and outside researchers will not have access to this information. Data is not to be shared with researchers outside the NA-MIC consortium.<br /> <br /> == Data Access ==<br /> <br /> A More detailed description of the data sets can be found [[DataRepository|here]]. Data includes:<br /> <br /> * 6 Healthy Controls Data<br /> ** SPGR<br /> ** T2<br /> ** fMRI (ER-RECOG task)<br /> ** DTI<br /> ** Hippocampus Traces – from Brains<br /> ** Hippocampal ROIs – Binary ROIs<br /> * MRI Data for 15 SZ<br /> ** SPGR<br /> ** Frontal Traces: 8 Structures (right and left) – from Brains<br /> <br /> == Collaborations ==<br /> <br /> * Working with Steve Pieper and Gordon Kindlmann to correctly incorporate new 3T data into Slicer.<br /> ** Have uploaded sample data to BIRN to address diffusion direction concern and eddy current correction testing. These action items were developed during May 19th, 2006 visit by Steve Pieper and Ron Kikinis to Dartmouth.<br /> * Correspondence with Steve Pieper to help debug Slicer 2.6 for 64-bit Linux.<br /> * Collaboration with Josh Snyder/David Tuch at Harvard on DTI Path of Interest Project.<br /> * Correspondence with Josh Snyder/Xiaodong Tao to help create script to convert Dartmouth data to nrrd format.<br /> * Collaboration with team at Harvard and Steve Pieper to help improve and get training on Slicer Editor, DTI-MRI module, and fMRI module.<br /> * Collaboration with Shenton Lab to port Dartmouth fMRI tasks to Harvard site for local (Boston) data collection.<br /> <br /> == Events ==<br /> <br /> * [[Slicer:StevePieper_RonKikinis_VisitToDartmouth_051906|May 19, 2006: Steve Pieper and Ron Kikinis Visit to Dartmouth]]<br /> * [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]<br /> * [[DBP:Brain_Imaging_Lab_Review_AHM|January 20 2006: Review of AHM for Dartmouth lab]]<br /> * [[AHM_2006:AHM_2006|January 8-13, 2006: The Second All-Hands-Meeting and Programming Event in Salt Lake City, Utah]]<br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]<br /> * [[Dissemination:Workshop_May_26-27_2005|May 26-27, 2005. User Training and Dissemination Workshop at Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_April_21_2005|April 21-22, 2005: Andy Saykin visit to Brigham and Women's Hospital and MIT]]<br /> * [[AHM_2005:Main|February 20-22, 2005 AHM in SLC]]<br /> <br /> == Ongoing NA-MIC Projects ==<br /> <br /> '''Structural Projects'''<br /> <br /> * Morphometry of medial temporal lobe structures in schizophrenia<br /> <br /> '''DTI Projects'''<br /> <br /> * Corpus Callosum Fiber Tractography in schizophrenia<br /> * Fractional anisotrophy in the uncinate fasciculus in schizophrenia and bipolar I disorder (replication and extension of Kubicki study)<br /> * Intergity of fronto-temporal circuitry in schizophrenia using path of interest analysis<br /> <br /> '''fMRI Projects'''<br /> <br /> * Neural substrates of working memory in schizophrenia: A parametric 3-Back study<br /> * Brain activation during a continuous verbal encoding and recognition task in schizophrenia<br /> * Fronto-temporal connectivity in schizophrenia during semantic memory<br /> <br /> == Publications and Presentations (that have used NA-MIC Tools) ==<br /> <br /> &lt;br /&gt;'''Peer Reviewed Journal Articles'''<br /> <br /> * Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., &amp; Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging<br /> <br /> * Roth RM, Koven, NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089, July 31, 2006. <br /> <br /> '''Abstracts and Conference Proceedings'''<br /> <br /> * West, J., Saykin, A., Roth, R., Flashman, L., Koven, N., Pendergrass, J.C., Arfanakis, K. (2007). Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers. To be presented at the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago, June.<br /> <br /> * Koven, N.S., Roth, R.M., Flashman, L.A., Randolph, J.J., Pixley, H.S., Ricketts, S.M., Wishart, H.A., &amp; Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230.<br /> <br /> * Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., &amp; Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.<br /> <br /> '''Presentations'''<br /> <br /> * 05/11/06 Robert M. Roth, Ph.D. The brain in obsessive-compulsive disorder: From Freud to fMRI. Colloquium lecture, Department of Psychology, Brooklyn College, New York.<br /> <br /> * 01/31/06 Robert M. Roth, Ph.D. Thinking again about the brain in obsessive-compulsive disorder. Grand rounds, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH.<br /> <br /> * 12/06/05 Robert M. Roth, Ph.D. Advances in the neuroimaging of obsessive-compulsive disorder. Invited continuing medical education lecture at Dartmouth College Health Services, Hanover, New Hampshire.<br /> <br /> * 12/02/05 Robert M. Roth, Ph.D. Neuroimaging of frontal-subcortical circuitry in obsessive- compulsive disorder. Invited lecture at the Centre de Recherche Fernand Seguin, Montreal.<br /> <br /> * 11/12/05 Robert M. Roth, Ph.D. OCD and the brain: Imaging symptoms and cognition. Invited lecture at the 3rd Annual Meeting of the Quebec Obsessive Compulsive Foundation, Montreal.</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:Dartmouth&diff=6035 2007-01-08T16:58:58Z

<p>Jdwest: </p> <hr /> <div>== IRB Information ==<br /> <br /> NA-MIC data is overseen by both the Dartmouth CPHS and the NH State IRB. We have received approval from each entity to share deidentified data with NA-MIC researchers via the wiki. The link between shared data and private subject IDs is kept at Dartmouth in a locked cabinet, within a locked office, and outside researchers will not have access to this information. Data is not to be shared with researchers outside the NA-MIC consortium.<br /> <br /> == Data Access ==<br /> <br /> A More detailed description of the data sets can be found [[DataRepository|here]]. Data includes:<br /> <br /> * 6 Healthy Controls Data<br /> ** SPGR<br /> ** T2<br /> ** fMRI (ER-RECOG task)<br /> ** DTI<br /> ** Hippocampus Traces – from Brains<br /> ** Hippocampal ROIs – Binary ROIs<br /> * MRI Data for 15 SZ<br /> ** SPGR<br /> ** Frontal Traces: 8 Structures (right and left) – from Brains<br /> <br /> == Collaborations ==<br /> <br /> * Working with Steve Pieper and Gordon Kindlmann to correctly incorporate new 3T data into Slicer.<br /> ** Have uploaded sample data to BIRN to address diffusion direction concern and eddy current correction testing. These action items were developed during May 19th, 2006 visit by Steve Pieper and Ron Kikinis to Dartmouth.<br /> * Correspondence with Steve Pieper to help debug Slicer 2.6 for 64-bit Linux.<br /> * Collaboration with Josh Snyder/David Tuch at Harvard on DTI Path of Interest Project.<br /> * Correspondence with Josh Snyder/Xiaodong Tao to help create script to convert Dartmouth data to nrrd format.<br /> * Collaboration with team at Harvard and Steve Pieper to help improve and get training on Slicer Editor, DTI-MRI module, and fMRI module.<br /> * Collaboration with Shenton Lab to port Dartmouth fMRI tasks to Harvard site for local (Boston) data collection.<br /> <br /> == Events ==<br /> <br /> * [[Slicer:StevePieper_RonKikinis_VisitToDartmouth_051906|May 19, 2006: Steve Pieper and Ron Kikinis Visit to Dartmouth]]<br /> * [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]<br /> * [[DBP:Brain_Imaging_Lab_Review_AHM|January 20 2006: Review of AHM for Dartmouth lab]]<br /> * [[AHM_2006:AHM_2006|January 8-13, 2006: The Second All-Hands-Meeting and Programming Event in Salt Lake City, Utah]]<br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]<br /> * [[Dissemination:Workshop_May_26-27_2005|May 26-27, 2005. User Training and Dissemination Workshop at Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_April_21_2005|April 21-22, 2005: Andy Saykin visit to Brigham and Women's Hospital and MIT]]<br /> * [[AHM_2005:Main|February 20-22, 2005 AHM in SLC]]<br /> <br /> == Ongoing NA-MIC Projects ==<br /> <br /> '''Structural Projects'''<br /> <br /> * Morphometry of medial temporal lobe structures in schizophrenia<br /> <br /> '''DTI Projects'''<br /> <br /> * Corpus Callosum Fiber Tractography in schizophrenia<br /> * Fractional anisotrophy in the uncinate fasciculus in schizophrenia and bipolar I disorder (replication and extension of Kubicki study)<br /> * Intergity of fronto-temporal circuitry in schizophrenia using path of interest analysis<br /> <br /> '''fMRI Projects'''<br /> <br /> * Neural substrates of working memory in schizophrenia: A parametric 3-Back study<br /> * Brain activation during a continuous verbal encoding and recognition task in schizophrenia<br /> * Fronto-temporal connectivity in schizophrenia during semantic memory<br /> <br /> == Publications and Presentations (that have used NA-MIC Tools) ==<br /> <br /> &lt;br /&gt;'''Peer Reviewed Journal Articles'''<br /> <br /> * Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., &amp; Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging<br /> <br /> * Roth RM, Koven, NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089, July 31, 2006. <br /> <br /> '''Abstracts and Conference Proceedings'''<br /> <br /> * West, J., Saykin, A., Roth, R., Flashman, L., Koven, N., Pendergrass, J.C., Arfanakis, K. (2007). Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers. To be presented at the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago, June.<br /> <br /> * Koven, N.S.,* Roth, R.M., Flashman, L.A., Randolph, J.J.,* Pixley, H.S.,* Ricketts, S.M., Wishart, H.A., &amp; Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230.<br /> <br /> * Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., &amp; Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.<br /> <br /> '''Presentations'''<br /> <br /> * 05/11/06 Robert M. Roth, Ph.D. The brain in obsessive-compulsive disorder: From Freud to fMRI. Colloquium lecture, Department of Psychology, Brooklyn College, New York.<br /> <br /> * 01/31/06 Robert M. Roth, Ph.D. Thinking again about the brain in obsessive-compulsive disorder. Grand rounds, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH.<br /> <br /> * 12/06/05 Robert M. Roth, Ph.D. Advances in the neuroimaging of obsessive-compulsive disorder. Invited continuing medical education lecture at Dartmouth College Health Services, Hanover, New Hampshire.<br /> <br /> * 12/02/05 Robert M. Roth, Ph.D. Neuroimaging of frontal-subcortical circuitry in obsessive- compulsive disorder. Invited lecture at the Centre de Recherche Fernand Seguin, Montreal.<br /> <br /> * 11/12/05 Robert M. Roth, Ph.D. OCD and the brain: Imaging symptoms and cognition. Invited lecture at the 3rd Annual Meeting of the Quebec Obsessive Compulsive Foundation, Montreal.</div>

Jdwest https://www.na-mic.org/w/index.php?title=DBP:Dartmouth&diff=6034 2007-01-08T16:54:59Z

<p>Jdwest: /* Publications and Presentations (that have used NA-MIC Tools) */</p> <hr /> <div>== IRB Information ==<br /> <br /> NA-MIC data is overseen by both the Dartmouth CPHS and the NH State IRB. We have received approval from each entity to share deidentified data with NA-MIC researchers via the wiki. The link between shared data and private subject IDs is kept at Dartmouth in a locked cabinet, within a locked office, and outside researchers will not have access to this information. Data is not to be shared with researchers outside the NA-MIC consortium.<br /> <br /> == Data Access ==<br /> <br /> A More detailed description of the data sets can be found [[DataRepository|here]]. Data includes:<br /> <br /> * 6 Healthy Controls Data<br /> ** SPGR<br /> ** T2<br /> ** fMRI (ER-RECOG task)<br /> ** DTI<br /> ** Hippocampus Traces – from Brains<br /> ** Hippocampal ROIs – Binary ROIs<br /> * MRI Data for 15 SZ<br /> ** SPGR<br /> ** Frontal Traces: 8 Structures (right and left) – from Brains<br /> <br /> == Collaborations ==<br /> <br /> * Working with Steve Pieper and Gordon Kindlmann to correctly incorporate new 3T data into Slicer.<br /> ** Have uploaded sample data to BIRN to address diffusion direction concern and eddy current correction testing. These action items were developed during May 19th, 2006 visit by Steve Pieper and Ron Kikinis to Dartmouth.<br /> * Correspondence with Steve Pieper to help debug Slicer 2.6 for 64-bit Linux.<br /> * Collaboration with Josh Snyder/David Tuch at Harvard on DTI Path of Interest Project.<br /> * Correspondence with Josh Snyder/Xiaodong Tao to help create script to convert Dartmouth data to nrrd format.<br /> * Collaboration with team at Harvard and Steve Pieper to help improve and get training on Slicer Editor, DTI-MRI module, and fMRI module.<br /> * Collaboration with Shenton Lab to port Dartmouth fMRI tasks to Harvard site for local (Boston) data collection.<br /> <br /> == Events ==<br /> <br /> * [[Slicer:StevePieper_RonKikinis_VisitToDartmouth_051906|May 19, 2006: Steve Pieper and Ron Kikinis Visit to Dartmouth]]<br /> * [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]<br /> * [[DBP:Brain_Imaging_Lab_Review_AHM|January 20 2006: Review of AHM for Dartmouth lab]]<br /> * [[AHM_2006:AHM_2006|January 8-13, 2006: The Second All-Hands-Meeting and Programming Event in Salt Lake City, Utah]]<br /> * [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]<br /> * [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]<br /> * [[Dissemination:Workshop_May_26-27_2005|May 26-27, 2005. User Training and Dissemination Workshop at Dartmouth]]<br /> * [[DBP:Andy_Saykin_visit_BWH_April_21_2005|April 21-22, 2005: Andy Saykin visit to Brigham and Women's Hospital and MIT]]<br /> * [[AHM_2005:Main|February 20-22, 2005 AHM in SLC]]<br /> <br /> == Ongoing NA-MIC Projects ==<br /> <br /> '''Structural Projects'''<br /> <br /> * Morphometry of medial temporal lobe structures in schizophrenia<br /> <br /> '''DTI Projects'''<br /> <br /> * Corpus Callosum Fiber Tractography in schizophrenia<br /> * Fractional anisotrophy in the uncinate fasciculus in schizophrenia and bipolar I disorder (replication and extension of Kubicki study)<br /> * Intergity of fronto-temporal circuitry in schizophrenia using path of interest analysis<br /> <br /> '''fMRI Projects'''<br /> <br /> * Neural substrates of working memory in schizophrenia: A parametric 3-Back study<br /> * Brain activation during a continuous verbal encoding and recognition task in schizophrenia<br /> * Fronto-temporal connectivity in schizophrenia during semantic memory<br /> <br /> == Publications and Presentations (that have used NA-MIC Tools) ==<br /> <br /> &lt;br /&gt;'''Peer Reviewed Journal Articles'''<br /> <br /> * Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., &amp; Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging<br /> <br /> * Roth RM, Koven, NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089, July 31, 2006. <br /> <br /> '''Abstracts and Conference Proceedings'''<br /> <br /> * Koven, N.S.,* Roth, R.M., Flashman, L.A., Randolph, J.J.,* Pixley, H.S.,* Ricketts, S.M., Wishart, H.A., &amp; Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230.<br /> <br /> * Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., &amp; Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.<br /> <br /> '''Presentations'''<br /> <br /> * 05/11/06 Robert M. Roth, Ph.D. The brain in obsessive-compulsive disorder: From Freud to fMRI. Colloquium lecture, Department of Psychology, Brooklyn College, New York.<br /> <br /> * 01/31/06 Robert M. Roth, Ph.D. Thinking again about the brain in obsessive-compulsive disorder. Grand rounds, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH.<br /> <br /> * 12/06/05 Robert M. Roth, Ph.D. Advances in the neuroimaging of obsessive-compulsive disorder. Invited continuing medical education lecture at Dartmouth College Health Services, Hanover, New Hampshire.<br /> <br /> * 12/02/05 Robert M. Roth, Ph.D. Neuroimaging of frontal-subcortical circuitry in obsessive- compulsive disorder. Invited lecture at the Centre de Recherche Fernand Seguin, Montreal.<br /> <br /> * 11/12/05 Robert M. Roth, Ph.D. OCD and the brain: Imaging symptoms and cognition. Invited lecture at the 3rd Annual Meeting of the Quebec Obsessive Compulsive Foundation, Montreal.</div>

Jdwest