2012 Winter Project Week:TBIDTIAnalysis - Revision history

Cvachet at 15:23, 13 January 2012

2012-01-13T15:23:01Z

Cvachet at 15:18, 7 December 2011

2011-12-07T15:18:27Z

Cvachet at 22:06, 6 December 2011

2011-12-06T22:06:15Z

Cvachet: Created page with 'NOTOC Image:PW-SLC2012.png|Projects List Image:MP_RAGE_PRECONTRAST.png‎|An example T1 weighted image from a patient with TBI…'

2011-12-06T22:01:08Z

Created page with '__NOTOC__ <gallery> Image:PW-SLC2012.png|Projects List Image:MP_RAGE_PRECONTRAST.png‎|An example T1 weighted image from a patient with TBI…'

New page

__NOTOC__
<gallery>
Image:PW-SLC2012.png|[[2012_Winter_Project_Week#Projects|Projects List]]
Image:MP_RAGE_PRECONTRAST.png‎|An example T1 weighted image from a patient with TBI
</gallery>

==Registration and analysis of white matter tract changes in TBI ==

==Key Investigators==
* UNC: Clement Vachet, Martin Styner
* Utah: Anuja Sharma, Marcel Prastawa, Guido Gerig
* Kitware: Danielle Pace, Stephen Aylward
* UCLA: Andrei Irimia, Jack van Horn

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<h3>Objective</h3>
In vivo neuroimaging is an increasingly relevant means for the neurological assessment of traumatic brain injury (TBI). However, standard automated image analysis methods are not sufficiently robust with respect to TBI-related changes in image contrast, brain shape, cranial fractures, white matter fiber alterations, and other signatures of head injury.
One of the objectives of the DBP is to develop robust workflows for diffusion weighted imaging (e.g. DTI, HARDI) datasets from TBI patients, by using the NA-MIC Kit and Slicer to obtain reliable and robust metrics of white matter pathology and of white matter changes due to therapy and/or recovery.
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<h3>Approach, Plan</h3>
*Feasibility test on shared dataset with respect to registration:
**Registration between acute and chronic data, i.e. only two time points but of course some deformation due to recovery.
**Registration to an atlas (more challenging)
*Discuss with interested parties to find optimal methods to handle large deformations
**Combine DTI with sMRI data
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<h3>Progress</h3>

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==Delivery Mechanism==

This work will be delivered to the NA-MIC Kit as a Slicer extension

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@@ Line 38: / Line 38: @@
 <h3>Progress</h3>
+*Discussion with UTAH team
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@@ Line 26: / Line 26: @@
 <h3>Approach, Plan</h3>
-*Feasibility test on shared dataset with respect to registration:
+*Objective: pairwise DTI registration and DTI analysis on TBI dataset
-**Registration between acute and chronic data, i.e. only two time points but of course some deformation due to recovery.
+**Registration between acute baseline and follow-up (only two time points with some deformation due to recovery).
-**Registration to an atlas (more challenging)
+**Registration from subject to atlas (more challenging)
-*Discuss with interested parties to find optimal methods to handle large deformations
+*Discuss with interested parties to find optimal methods handling such large deformations
-**Combine DTI with sMRI data
+*Perform feasibility test on [[DBP3:UCLA#Results|sample DTI dataset]]
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@@ Line 20: / Line 20: @@
 <h3>Objective</h3>
 In vivo neuroimaging is an increasingly relevant means for the neurological assessment of traumatic brain injury (TBI). However, standard automated image analysis methods are not sufficiently robust with respect to TBI-related changes in image contrast, brain shape, cranial fractures, white matter fiber alterations, and other signatures of head injury.
-One of the objectives of the DBP is to develop robust workflows for diffusion weighted imaging (e.g. DTI, HARDI) datasets from TBI patients, by using the NA-MIC Kit and Slicer to obtain reliable and robust metrics of white matter pathology and of white matter changes due to therapy and/or recovery.
+One of the objectives of the [http://www.na-mic.org/pages/DBP:TBI DBP] is to develop robust workflows for diffusion weighted imaging (e.g. DTI, HARDI) datasets from TBI patients, by using the NA-MIC Kit and Slicer to obtain reliable and robust metrics of white matter pathology and of white matter changes due to therapy and/or recovery.
 </div>

2012 Winter Project Week:TBIDTIAnalysis - Revision history

Cvachet at 15:23, 13 January 2012

Cvachet at 15:18, 7 December 2011

Cvachet at 22:06, 6 December 2011

Cvachet: Created page with '__NOTOC__ Image:PW-SLC2012.png|Projects List Image:MP_RAGE_PRECONTRAST.png‎|An example T1 weighted image from a patient with TBI…'

Cvachet: Created page with 'NOTOC Image:PW-SLC2012.png|Projects List Image:MP_RAGE_PRECONTRAST.png‎|An example T1 weighted image from a patient with TBI…'