2016 Winter Project Week/Projects/DSCAnalysis - Revision history

Stevedaxiao at 22:55, 7 January 2016

2016-01-07T22:55:14Z

2016-01-07T22:54:51Z

Project Description

2016-01-07T22:51:02Z

2016-01-07T22:45:11Z

2016-01-07T21:58:07Z

Project Description

2016-01-07T17:02:23Z

2016-01-07T16:40:23Z

2016-01-07T05:30:21Z

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 <!-- Progress and Next steps bullet points (fill out at the end of project week -->
-* Finalize the source code
+* Finalized the source code
 * Finished the DSC analysis module packaging
 * Moved repository to QIICR on Github

@@ Line 40: / Line 40: @@
+|
 <!-- Progress and Next steps bullet points (fill out at the end of project week -->
 * Finished the DSC analysis module packaging
 * Moved repository to QIICR on Github
 * Picked up few MGH GBM cases and ran commercial software for comparison
 * Updated the Slicer wiki page for DSC analysis module (http://slicer.org/slicerWiki/index.php/Documentation/Nightly/Modules/DSC_MRI_Analysis)
 * Released the module

@@ Line 42: / Line 42: @@
 * Finished the DSC analysis module packaging
 * Moved repository to QIICR on Github
 * Picked up few MGH GBM cases and ran commercial software for comparison
 * Updated the Slicer wiki page for DSC analysis module (http://slicer.org/slicerWiki/index.php/Documentation/Nightly/Modules/DSC_MRI_Analysis)
 * Released the module
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 * [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208985/pdf/nihms596683.pdf Other method to investigate DSC MRI]
 * [http://www.ncbi.nlm.nih.gov/pubmed/16611779 Leakage correction for DSC MRI]

@@ Line 40: / Line 40: @@
+|
 <!-- Progress and Next steps bullet points (fill out at the end of project week -->
-* Finished the packaging of the DSC analysis module
+* Finished the DSC analysis module packaging
 * Moved repository to QIICR on Github
-* Randomly picked few MGH GBM cases and ran commercial software for comparison
+* Picked up few MGH GBM cases and ran commercial software for comparison
 * Released the module
 |}

@@ Line 41: / Line 41: @@
 <!-- Progress and Next steps bullet points (fill out at the end of project week -->
 * Finished the packaging of the DSC analysis module
 * Randomly picked few MGH GBM cases and ran commercial software for comparison
+* Released the module
 |}

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 Dynamic Susceptibility Contrast (DSC) MRI imaging is an important functional imaging method that enables quantitative assessment of tissue hemodynamic patterns. Abnormality of blood flow, volume and permeability is frequently observed during tumor growth, and characterization of these perfusion attributes has become clinically important for both diagnosis and therapy planning. In the context of glial neoplasms, perfusion characteristics have been shown to correlate with tumor type and grade and hence influence treatment decisions.
 DSC MRI imaging is based on the principle that flow of a paramagnetic contrast agent through a capillary bed will transiently change the magnetic susceptibility of the given tissue. Decreased signal intensity on spin-echo or gradient-echo images after the first pass of the contrast agent, frequently described as susceptibility-induced T2* shortening, is the result of this temporal change in magnetic susceptibility. This signal time curve is then converted into a concentration time curve, and use of tracer kinetic analysis various hemodynamic variables, such as cerebral blood volume, cerebral blood flow, and mean transit time, as well as metrics that address vessel leakage may be estimated. Combined, these metrics enable microvascular imaging, providing a visual correlate of blood flow, volume, and vessel permeability.
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 <gallery>
 Image:PW-MIT2016.png|link=2016_Winter_Project_Week#Projects|[[2016_Winter_Project_Week#Projects|Projects List]]
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