Ygao at 01:14, 16 November 2013

2013-11-16T01:14:35Z

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2007-01-05T18:34:43Z

Update from Wiki

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'''Objective:'''

The goal of this work is to generate centerlines from segmented 3D surfaces of blood '''vessels''' using a harmonic skeletonization technique. The generated centerlines are used as a guide to visualize and evaluate stenoses in human coronary arteries. A harmonic skeleton is the center line of a multi-branched tubular surface extracted based on a harmonic function, which is the solution of the Laplace equation. This skeletonization method guarantees smoothness and connectivity and provides a fast and straightforward way to calculate local cross-sectional areas of the arteries, and thus provides the possibility to localize and evaluate coronary artery stenosis, which is a commonly seen pathology in coronary artery disease.

'''Progress:'''

[[Image:Skeletons.TIF|[[Image:874px-Skeletons.TIF.png]]]]

Figure 1 shows the '''centerline''' extraction results on two coronary artery tress. Left: Coronaries and the skeleton of a healthy volunteer. Middle: Coronaries and the skeleton of a patient with plaques in LAD. Right: The skeleton of the middle coronaries.

[[Image:Areas.TIF|[[Image:397px-Areas.TIF.png]]]]

[[Image:Stenosis_quan.TIF|[[Image:579px-Stenosis_quan.TIF.png]]]]

[[Image:LAD_stenosis.JPG|[[Image:LAD_stenosis.JPG]]]]

<br /> Cross-sectional areas of '''vessels''' can be calculated using the centerlines as a guide. Figure 3 shows the areas at different locations along the '''vessels''' by specifying a ''u'' value of the harmonic function (solution to the Laplace equation). We can also show a continuous variation of the cross-sectional area along a certain vessel, as shown in Figure 4, where the areas along the left anterior descending (LAD) coronary artery of the second case in Figure 1 are measured. Figure 5 shows a stenosis detected in this vessel.

''Ongoing Work''

* This method is being tested and evaluated for its accuracy based on more clinical data sets.
* The algorithms used in this work are currently implemented in MATLAB and C.

''References:''

[1] Y. Yang, L. Zhu, S. Haker, A. Tannenbaum, and D. Giddens. [/Wiki/images/8/83/YangMICCAI2005.pdf Harmonic Skeleton Guided Evaluation of Stenoses in Human Coronary Arteries]. In Proc. MICCAI 2005: International Conference Medical Image Computing and Computer-Assisted Intervention, Lecture Notes in Computer Science (3749). Springer-Verlag, pp.490-497, 2005

'''Links:'''

* [[Algorithm:GATech|Georgia Tech Algorithms]]
* [[NA-MIC_Collaborations|NA-MIC Collaborations]]

@@ Line 30: / Line 30: @@
 '''Links:'''
-* [[Algorithm:GATech|Georgia Tech Algorithms]]
+* [[Algorithm:Stony Brook|Stony Brook Algorithms]]
 * [[NA-MIC_Collaborations|NA-MIC Collaborations]]

Algorithm:GATech:Centerline Generation for Vessels - Revision history

Ygao at 01:14, 16 November 2013

Zack: Update from Wiki