CTSC:BIDMCresources:MRIresearch - Revision history

Valerie.humblet: Replaced content with 'Back to BIDMC MRI Imaging Resources'

2009-04-14T19:05:06Z

Replaced content with 'Back to BIDMC MRI Imaging Resources'

Valerie.humblet: /* Center for Basic MR Research */

2009-04-14T18:56:10Z

Center for Basic MR Research

Valerie.humblet: /* Cardiac MR */

2009-04-14T18:54:28Z

Cardiac MR

Valerie.humblet at 18:49, 14 April 2009

2009-04-14T18:49:51Z

Valerie.humblet: /* Center for Basic MR Research */

2009-04-14T18:45:53Z

Center for Basic MR Research

Valerie.humblet: /* Center for Basic MR Research */

2009-04-14T18:44:42Z

Center for Basic MR Research

Valerie.humblet: /* Center for Basic MR Research */

2009-04-14T18:42:13Z

Center for Basic MR Research

Valerie.humblet: /* Center for Basic MR Research */

2009-04-14T18:40:26Z

Center for Basic MR Research

Valerie.humblet: /* Center for Basic MR Research */

2009-04-14T18:38:48Z

Center for Basic MR Research

Valerie.humblet at 18:36, 14 April 2009

2009-04-14T18:36:25Z

← Older revision		Revision as of 19:05, 14 April 2009
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	[[CTSC:BIDMCresources:MRI\|Back to BIDMC MRI Imaging Resources]]		[[CTSC:BIDMCresources:MRI\|Back to BIDMC MRI Imaging Resources]]
−
−	One major focus of the research efforts in the Department of Radiology at BIDMC is the facilitation of translational research in which advances in the basic science sections are translated into improvements in patient care.
−
−	~~=Types of studies appropriate for use the MRI Research Scanners=~~
−
−	The scanners are intended to support research, which may include technical development of MRI methods, studies evaluating MRI as a diagnostic or physiologic marker, studies using MRI as a marker or measure in other kinds of research, and clinical trials using MRI as an indicator of response. While the scanners are designed for human studies, studies of non-biological or biological specimens and animal models may also be suitable.
−
−	~~=Scanners=~~
−
−	This research division has a GE 3T and a GE 1.5T whole body scanners completely dedicated to research. Both are FDA approved and operate with current state-of-the-art hardware and software including higher order shimming. In addition we have access to proprietary software including pulse programming environments and reconstruction programs. Both scanners are equipped with Medrad power injectors for contrast administration and physiologic patient monitors. Patient monitoring within both magnets includes non-invasive measures of heart rate, blood pressure, pulse-oximetry, and end tidal CO2 levels and 40 channel EEG recording.
−
−	*'''GE 3T whole body '''
−
−	The 3T system has product high-speed imaging/echo planar imaging capabilities. Support for fMRI acquisition and stimulus presentation, diffusion tensor imaging, and high quality anatomic imaging is available. The system has specialized receiver coils for sensitive imaging of particular anatomy including prostate, carotids, knees, and spine. Additional customized coils can be manufactured in our RF lab. The system also has full broadband capability for multinuclear MRI and MRS, including (F-19, C-13, P-31, and Na-23).
−
−	*'''GE 1.5T whole body'''
−
−	The 1.5 T scanner operates with current state-of-the-art hardware and software including higher order shimming. In addition we have access to proprietary software and developmental data acquisition and reconstruction programs. This scanner is equipped with a 32 channel receiver system and 32 element coils. A focus of this system is highly accelerated imaging of the body for reduced motion and realization of functional contrast.
−
−	~~=Additional Services=~~
−
−	Our facility can also provide or facilitate Clinical Reading, Image Management, Image Post-processing, MRI Compatible Equipment, Computerized image transfer of multi-center trial data and Site certification
−
−	~~=Cardiac MR=~~
−
−	The BIDMC Cardiac MR Center is a joint effort of the Departments of Medicine (Cardiovascular Division) and Radiology. Established in the Spring of 1995, it was one of the very first MR Centers specifically focused on cardiovascular MR. The primary goals of the Cardiac MR Center are the development and clinical application of MR imaging to the cardiovascular system. The Center has specific interest in coronary MR angiography and MR assessment of ventricular function and valvular heart disease. The Center is also committed to the education and training of interested researchers and clinicians. Funding for the Cardiac MR Center is provided by grants from the NIH/NHLBI, American Heart Association, industry, private foundations, and Individual contributions. BIDMC's Cardiac MR Center is a world leader in the development and clinical use of cardiac MR for coronary artery imaging, and for assessing cardiomyopathies and viability, pericardial disease and congenital heart disease. The center features a state-of-the-art 1.5T dedicated Philips Cardiac MR system. For additional information, please contact [mailto:wmanning@bidmc.harvard.edu Warren J Manning], MD, Director, Cardiac MRI.
−
−	~~=Center for Basic MR Research=~~
−
−	The BIDMC Center for Basic MR Research provides facilities for NMR spectroscopy and MRI studies of cell culture, perfused organ, excised tissue, and in vivo small animal protocols. The Center operates on an hourly fee basis. [mailto:dburstei@bidmc.harvard.edu Dr Deborah Burstein], the Director of the facility is available to discuss potential projects.
−
−	*'''8.5 Tesla, 9 cm bore vertical magnet; Bruker DRX system'''
−	~~The 8.5 Tesla vertical bore magnet is equipped with a self-shielded gradient set of 40 mm diameter ID and 75 G/cm maximum gradient strength.~~
−	A "micromouse" probe is available with a 30 mm ID proton rf coil which can be used for whole body mouse imaging. Cardiac and respiratory gating and monitoring are available with this probe, as are inhalation anesthetics.<br>
−	~~A second probe is available with interchangeable rf coils, including:<br>~~
−	~~- bird cage coils with internal diameters of 10 mm, 20 mm, 25 mm<br>~~
−	~~- solenoid coils with diameters of 3 mm, 5 mm<br>~~
−	~~- dual tuned coils of P31/H1 in 25 mm diameter<br>~~
−	~~- surface coil of 1 cm diameter<br>~~
−
−	*'''4.7 Tesla, 40 cm bore actively shielded Bruker Biospec Magnet System'''
−	~~The actively shielded 40 cm bore system has the following two gradient sets available:<br>~~
−	~~- 26 cm ID (slew rates: 250 µsec, Maximum gradient: 9 G/cm)<br>~~
−	~~- 12 cm ID (slew rates: 120 µsec, Maximum gradient: 30 G/cm)<br>~~
−	~~In addition, there are a number of rf coils available for use, including:<br>~~
−	~~- bird cage coils 35 mm, 70 mm, 150 mm, 200 mm (ID)<br>~~
−	~~- surface coils, with active decoupling for receive-only operation 15 mm, 30 mm (ID)~~
−
−	*'''Gas anesthesia and animal monitoring facilities '''
−	~~- A nose cone is used for anesthetic inhalation. <br>~~
−	- Respiratory monitoring is available through the use of a pressure transducer placed on the abdominal area of the animal, and ECG monitoring is available through ECG leads. The resulting signals are displayed on a Bruker Physiogard unit, and can be used for triggering of the MRI sequences. Triggering can be respiratory, cardiac, or a combination.
−
−	*'''Data processing'''
−	Data processing facilities include 2 IBM based PCs, both with data backup capabilities and standard programs such as Office. In addition, Matlab is running on both systems, with a GUI image processing program written specifically for MRI applications. Fitting routines for T1, T, diffusion, and ASL perfusion imaging are available, with the possibility to update to other modules. The program will produce a color coded overlay of calculated parameter maps overlaid on the proton based image. In addition, the statistics of a given ROI, or fit of a given pixel, are available.

@@ Line 29: / Line 29: @@
 =Center for Basic MR Research=
-The BIDMC Center for Basic MR Research provides facilities for NMR spectroscopy and MRI studies of cell culture, perfused organ, excised tissue, and in vivo small animal protocols. The Center operates on an hourly fee basis. Dr. Deborah Burstein, the Director of the facility (dburstei@bidmc.harvard.edu) is available to discuss potential projects.
+The BIDMC Center for Basic MR Research provides facilities for NMR spectroscopy and MRI studies of cell culture, perfused organ, excised tissue, and in vivo small animal protocols. The Center operates on an hourly fee basis. [mailto:dburstei@bidmc.harvard.edu Dr Deborah Burstein], the Director of the facility  is available to discuss potential projects.
 *'''8.5 Tesla, 9 cm bore vertical magnet; Bruker DRX system'''

@@ Line 25: / Line 25: @@
 =Cardiac MR=
-The BIDMC Cardiac MR Center is a joint effort of the Departments of Medicine (Cardiovascular Division) and Radiology. Established in the Spring of 1995, it was one of the very first MR Centers specifically focused on cardiovascular MR. The primary goals of the Cardiac MR Center are the development and clinical application of MR imaging to the cardiovascular system. The Center has specific interest in coronary MR angiography and MR assessment of ventricular function and valvular heart disease. The Center is also committed to the education and training of interested researchers and clinicians. Funding for the Cardiac MR Center is provided by grants from the NIH/NHLBI, American Heart Association, industry, private foundations, and Individual contributions. BIDMC's Cardiac MR Center is a world leader in the development and clinical use of cardiac MR for coronary artery imaging, and for assessing cardiomyopathies and viability, pericardial disease and congenital heart disease. The center features a state-of-the-art 1.5T dedicated Philips Cardiac MR system. For additional information, please contact [mailto: wmanning@bidmc.harvard.edu Warren J Manning], MD, Director, Cardiac MRI at
+The BIDMC Cardiac MR Center is a joint effort of the Departments of Medicine (Cardiovascular Division) and Radiology. Established in the Spring of 1995, it was one of the very first MR Centers specifically focused on cardiovascular MR. The primary goals of the Cardiac MR Center are the development and clinical application of MR imaging to the cardiovascular system. The Center has specific interest in coronary MR angiography and MR assessment of ventricular function and valvular heart disease. The Center is also committed to the education and training of interested researchers and clinicians. Funding for the Cardiac MR Center is provided by grants from the NIH/NHLBI, American Heart Association, industry, private foundations, and Individual contributions. BIDMC's Cardiac MR Center is a world leader in the development and clinical use of cardiac MR for coronary artery imaging, and for assessing cardiomyopathies and viability, pericardial disease and congenital heart disease. The center features a state-of-the-art 1.5T dedicated Philips Cardiac MR system. For additional information, please contact [mailto:wmanning@bidmc.harvard.edu Warren J Manning], MD, Director, Cardiac MRI.
 =Center for Basic MR Research=

@@ Line 25: / Line 25: @@
 =Cardiac MR=
-The BIDMC Cardiac MR Center is a joint effort of the Departments of Medicine (Cardiovascular Division) and Radiology. Established in the Spring of 1995, it was one of the very first MR Centers specifically focused on cardiovascular MR. The primary goals of the Cardiac MR Center are the development and clinical application of MR imaging to the cardiovascular system. The Center has specific interest in coronary MR angiography and MR assessment of ventricular function and valvular heart disease. The Center is also committed to the education and training of interested researchers and clinicians. Funding for the Cardiac MR Center is provided by grants from the NIH/NHLBI, American Heart Association, industry, private foundations, and Individual contributions. BIDMC's Cardiac MR Center is a world leader in the development and clinical use of cardiac MR for coronary artery imaging, and for assessing cardiomyopathies and viability, pericardial disease and congenital heart disease. The center features a state-of-the-art 1.5T dedicated Philips Cardiac MR system. For additional information, please contact Warren J Manning, MD, Director, Cardiac MRI at wmanning@bidmc.harvard.edu
+The BIDMC Cardiac MR Center is a joint effort of the Departments of Medicine (Cardiovascular Division) and Radiology. Established in the Spring of 1995, it was one of the very first MR Centers specifically focused on cardiovascular MR. The primary goals of the Cardiac MR Center are the development and clinical application of MR imaging to the cardiovascular system. The Center has specific interest in coronary MR angiography and MR assessment of ventricular function and valvular heart disease. The Center is also committed to the education and training of interested researchers and clinicians. Funding for the Cardiac MR Center is provided by grants from the NIH/NHLBI, American Heart Association, industry, private foundations, and Individual contributions. BIDMC's Cardiac MR Center is a world leader in the development and clinical use of cardiac MR for coronary artery imaging, and for assessing cardiomyopathies and viability, pericardial disease and congenital heart disease. The center features a state-of-the-art 1.5T dedicated Philips Cardiac MR system. For additional information, please contact [mailto: wmanning@bidmc.harvard.edu Warren J Manning], MD, Director, Cardiac MRI at
 =Center for Basic MR Research=

@@ Line 29: / Line 29: @@
 =Center for Basic MR Research=
-The BIDMC Center for Basic MR Research provides facilities for NMR spectroscopy and MRI studies of cell culture, perfused organ, excised tissue, and in vivo small animal protocols.
+The BIDMC Center for Basic MR Research provides facilities for NMR spectroscopy and MRI studies of cell culture, perfused organ, excised tissue, and in vivo small animal protocols. The Center operates on an hourly fee basis. Dr. Deborah Burstein, the Director of the facility (dburstei@bidmc.harvard.edu) is available to discuss potential projects.
 *'''8.5 Tesla, 9 cm bore vertical magnet; Bruker DRX system'''

← Older revision		Revision as of 18:44, 14 April 2009
Line 51:		Line 51:
	- A nose cone is used for anesthetic inhalation. <br>		- A nose cone is used for anesthetic inhalation. <br>
	- Respiratory monitoring is available through the use of a pressure transducer placed on the abdominal area of the animal, and ECG monitoring is available through ECG leads. The resulting signals are displayed on a Bruker Physiogard unit, and can be used for triggering of the MRI sequences. Triggering can be respiratory, cardiac, or a combination.		- Respiratory monitoring is available through the use of a pressure transducer placed on the abdominal area of the animal, and ECG monitoring is available through ECG leads. The resulting signals are displayed on a Bruker Physiogard unit, and can be used for triggering of the MRI sequences. Triggering can be respiratory, cardiac, or a combination.
		+
		+	*'''Data processing'''
		+	Data processing facilities include 2 IBM based PCs, both with data backup capabilities and standard programs such as Office. In addition, Matlab is running on both systems, with a GUI image processing program written specifically for MRI applications. Fitting routines for T1, T, diffusion, and ASL perfusion imaging are available, with the possibility to update to other modules. The program will produce a color coded overlay of calculated parameter maps overlaid on the proton based image. In addition, the statistics of a given ROI, or fit of a given pixel, are available.

← Older revision		Revision as of 18:42, 14 April 2009
Line 47:		Line 47:
	- bird cage coils 35 mm, 70 mm, 150 mm, 200 mm (ID)<br>		- bird cage coils 35 mm, 70 mm, 150 mm, 200 mm (ID)<br>
	- surface coils, with active decoupling for receive-only operation 15 mm, 30 mm (ID)		- surface coils, with active decoupling for receive-only operation 15 mm, 30 mm (ID)
		+
		+	*'''Gas anesthesia and animal monitoring facilities '''
		+	- A nose cone is used for anesthetic inhalation. <br>
		+	- Respiratory monitoring is available through the use of a pressure transducer placed on the abdominal area of the animal, and ECG monitoring is available through ECG leads. The resulting signals are displayed on a Bruker Physiogard unit, and can be used for triggering of the MRI sequences. Triggering can be respiratory, cardiac, or a combination.

← Older revision		Revision as of 18:40, 14 April 2009
Line 30:		Line 30:

	The BIDMC Center for Basic MR Research provides facilities for NMR spectroscopy and MRI studies of cell culture, perfused organ, excised tissue, and in vivo small animal protocols.		The BIDMC Center for Basic MR Research provides facilities for NMR spectroscopy and MRI studies of cell culture, perfused organ, excised tissue, and in vivo small animal protocols.
−	~~Equipment in the facility includes 2 MR spectroscopy/imaging systems:~~

	*'''8.5 Tesla, 9 cm bore vertical magnet; Bruker DRX system'''		*'''8.5 Tesla, 9 cm bore vertical magnet; Bruker DRX system'''

← Older revision		Revision as of 18:38, 14 April 2009
Line 40:		Line 40:
	- dual tuned coils of P31/H1 in 25 mm diameter<br>		- dual tuned coils of P31/H1 in 25 mm diameter<br>
	- surface coil of 1 cm diameter<br>		- surface coil of 1 cm diameter<br>
		+
		+	*'''4.7 Tesla, 40 cm bore actively shielded Bruker Biospec Magnet System'''
		+	The actively shielded 40 cm bore system has the following two gradient sets available:<br>
		+	- 26 cm ID (slew rates: 250 µsec, Maximum gradient: 9 G/cm)<br>
		+	- 12 cm ID (slew rates: 120 µsec, Maximum gradient: 30 G/cm)<br>
		+	In addition, there are a number of rf coils available for use, including:<br>
		+	- bird cage coils 35 mm, 70 mm, 150 mm, 200 mm (ID)<br>
		+	- surface coils, with active decoupling for receive-only operation 15 mm, 30 mm (ID)

@@ Line 34: / Line 34: @@
 *'''8.5 Tesla, 9 cm bore vertical magnet; Bruker DRX system'''
 The 8.5 Tesla vertical bore magnet is equipped with a self-shielded gradient set of 40 mm diameter ID and 75 G/cm maximum gradient strength.
-A "micromouse" probe is available with a 30 mm ID proton rf coil which can be used for whole body mouse imaging. Cardiac and respiratory gating and monitoring are available with this probe, as are inhalation anesthetics.
+A "micromouse" probe is available with a 30 mm ID proton rf coil which can be used for whole body mouse imaging. Cardiac and respiratory gating and monitoring are available with this probe, as are inhalation anesthetics.<br>
-A second probe is available with interchangeable rf coils, including:
+A second probe is available with interchangeable rf coils, including:<br>
-- bird cage coils with internal diameters of 10 mm, 20 mm, 25 mm
+- bird cage coils with internal diameters of 10 mm, 20 mm, 25 mm<br>
-- solenoid coils with diameters of 3 mm, 5 mm
+- solenoid coils with diameters of 3 mm, 5 mm<br>
-- dual tuned coils of P31/H1 in 25 mm diameter
+- dual tuned coils of P31/H1 in 25 mm diameter<br>
-- surface coil of 1 cm diameter
+- surface coil of 1 cm diameter<br>