CTSC:multicenter101410 - Revision history

Valerie.humblet: /* Next steps */

2010-11-16T19:56:49Z

Next steps

Valerie.humblet: /* Next steps */

2010-11-16T19:55:07Z

Next steps

Valerie.humblet: /* Next steps */

2010-11-16T19:53:12Z

Next steps

Valerie.humblet at 19:48, 16 November 2010

2010-11-16T19:48:14Z

Valerie.humblet at 19:27, 16 November 2010

2010-11-16T19:27:01Z

Valerie.humblet at 19:20, 16 November 2010

2010-11-16T19:20:36Z

Valerie.humblet: Created page with 'Back to Collaboration:Harvard_CTSC
'''Agenda''' == Multicenter Clinical Trail Working group Meeting Minutes October 14, 2010 == In attend…'

2010-11-05T16:03:03Z

Created page with 'Back to Collaboration:Harvard_CTSC <br> '''Agenda''' == Multicenter Clinical Trail Working group Meeting Minutes October 14, 2010 == In attend…'

New page

Back to [[Collaboration:Harvard_CTSC|Collaboration:Harvard_CTSC]]
<br>

'''Agenda'''

== Multicenter Clinical Trail Working group Meeting Minutes October 14, 2010 ==

In attendance:

* Valerie Humblet
* Bob Lenkinski
* Clare Tempany
* Charles Guttmann
* Simon Warfield
<br>

@@ Line 35: / Line 35: @@
 * Implement a virtual PET trial
-* Look at ACRIN for example son multi-center CT trials (ex: liver, colonography: Daniel Jonhson)
+* Look at ACRIN for examples of multi-center CT trials (ex: liver, [http://www.acr.org/MainMenuCategories/media_room/FeaturedCategories/Videos/CTC-Trial.aspx colonography])
 * Standardization of dose measurement
 * Talk about IRB issues
 * Think about funding mechanism

@@ Line 35: / Line 35: @@
 * Implement a virtual PET trial
-* Look at ACRIN for example son multi-center CT trials (ex: liver)
+* Look at ACRIN for example son multi-center CT trials (ex: liver, colonography: Daniel Jonhson)
 * Standardization of dose measurement
 * Talk about IRB issues
 * Think about funding mechanism

← Older revision		Revision as of 19:53, 16 November 2010
Line 38:		Line 38:
	* Standardization of dose measurement		* Standardization of dose measurement
	* Talk about IRB issues		* Talk about IRB issues
		+	* Think about funding mechanism

@@ Line 19: / Line 19: @@
 ===MRI neuroimaging virtual trial===
-* It will be done with 3T MRI scanners, without contrast, with a multi-element head coil. Three sequences will be run: T2 weighted, FLAIR and MP RAGE. We will Implement common protocol with human phantoms.
+* It will be done with 3T MRI scanners, without contrast, with a multi-element head coil. Three sequences will be run: T2 weighted, FLAIR and MP RAGE. We will implement a common protocol with human phantoms.
+* The dataset will be transfer on a server (HIPPA compliant) and  we will look for reproducibility for 3 outcome measures; total brain volume, CFS and white vs gray matter.
+* The goal is to understand where protocols are equivalent and different. Need to understand intra- and inter- variability. We will also test the differences obtained with different versions of same software.
-Bodypart: neuroimaging, there is already a common neuro protocol for pediatric MS.
+* We will also do a pediatric version of the trial:
-take the dataset and look for reproducibility for 3 outcome measures; total brain volume, CFS and white/gray matter.
+* We can offer recommendation on the best phantoms for a specific disease. We also offer advices on calibration of theses phantoms.
-understand where protocols are equivalent and different. Need to understand intra- and inter- variability
+* Important questions: How often do we do the scanning, how many volunteer does one need to be relevant, what about gender (it is best to cover age and gender but it will depend on the disease).
-Test difference obtained with different version of same software
+* Validation: there must be a consensus between segmentation, [http://crl.med.harvard.edu/research/STAPLE/index.php  Staple] is a good tool to provide for validation.
-=== Extension to other disease and modalities===
+===Next steps===
-* We offer recommendation on the best phantoms for a specific disease. We also offer advices on calibration of theses phantoms.
+* Implement a virtual PET trial

@@ Line 17: / Line 17: @@
 <br>
-Modalities to start with: CT and MRI, protocol without contrast
+===MRI neuroimaging virtual trial===
 Bodypart: neuroimaging, there is already a common neuro protocol for pediatric MS.
-Example: 3 sites, 3 MRI scanners 3T: 1 GE, 1 Philips and 1 Siemens:
-Implement common protocol with human phantoms
 take the dataset and look for reproducibility for 3 outcome measures; total brain volume, CFS and white/gray matter.
 understand where protocols are equivalent and different. Need to understand intra- and inter- variability
 Test difference obtained with different version of same software

@@ Line 4: / Line 4: @@
 '''Agenda'''
+# establishment of the first virtual trial
 == Multicenter Clinical Trail Working group Meeting Minutes October 14, 2010 ==
@@ Line 16: / Line 16: @@
 * Simon Warfield
 <br>

CTSC:multicenter101410 - Revision history

Valerie.humblet: /* Next steps */

Valerie.humblet: /* Next steps */

Valerie.humblet: /* Next steps */

Valerie.humblet at 19:48, 16 November 2010

Valerie.humblet at 19:27, 16 November 2010

Valerie.humblet at 19:20, 16 November 2010

Valerie.humblet: Created page with 'Back to Collaboration:Harvard_CTSC '''Agenda''' == Multicenter Clinical Trail Working group Meeting Minutes October 14, 2010 == In attend…'

Valerie.humblet: Created page with 'Back to Collaboration:Harvard_CTSC
'''Agenda''' == Multicenter Clinical Trail Working group Meeting Minutes October 14, 2010 == In attend…'