https://www.na-mic.org/w/index.php?action=history&feed=atom&title=Collaboration%3AUNC-PNLCollaboration:UNC-PNL - Revision history2026-04-22T03:48:01ZRevision history for this page on the wikiMediaWiki 1.33.0https://www.na-mic.org/w/index.php?title=Collaboration:UNC-PNL&diff=4640&oldid=prevAndy: Update from Wiki2006-12-18T19:26:05Z<p>Update from Wiki</p>
<p><b>New page</b></p><div>== Goal ==<br />
<br />
* Reviewing shape analysis with current NAMIC data<br />
* Establishing a concrete plan and schedule for collaborations. Target projects are shape analysis and statistical analysis of anisotropy measure along fibers.<br />
<br />
== Agenda ==<br />
<br />
* 10am: UNC presentations for Psychiatrists/Psychologists:<br />
** Shape Analysis of Caudate and Corpus Callosum Data (30 min)[[Image:2005_NAMIC_ShapeSchizoBWH.ppt|Image:2005 NAMIC ShapeSchizoBWH.ppt]]<br />
** ITK SNAP: A level Set Semi Automatic Segmentation tool and its use at UNC for the segmentation of brain structures [[Image:2005_NAMIC_ShapeSchizoBWH.ppt|Image:2005 NAMIC ShapeSchizoBWH.ppt]]<br />
** UNC Tools for the Statistical Analysis of Anisotropy of Diffusion Tensor Measures along White Matter Fibers. (30min) [[Image:Isabelle100705-1.ppt|Image:Isabelle100705-1.ppt]]<br />
<br />
* 11:15am: Open Discussion with PNL on immediate and future collaborations plans.<br />
** Establish what UNC needs from PNL and PNL from UNC.<br />
** Resolve technical issues such authorship, clinical data, etc...<br />
<br />
* 12pm: Lunch<br />
* 1pm: Wrap up of PNL/UNC collaboration plans<br />
* 2pm: UNC presentations for Computer Scientists.<br />
** Shape Analysis: UNC Shape Analysis Pipeline in ITK/NAMIC [[Image:2005_10_ShapePipeline.ppt|Image:2005 10 ShapePipeline.ppt]]<br />
** Shape Analysis: Statistical Non-Parametric Permutation tests for shape hypothesis testing, [[Image:2005_10_NonParamShapeStats.ppt|Image:2005 10 NonParamShapeStats.ppt]]<br />
** DTI Tensor Analysis [[Image:Isabelle100705-2.ppt|Image:Isabelle100705-2.ppt]]<br />
<br />
== Participants ==<br />
<br />
* Martin Styner (UNC)<br />
* Isabelle Corouge (UNC)<br />
* Martha Shenton (PNL)<br />
* James Levitt (PNL)<br />
* Marek Kubicki (PNL)<br />
* C-F Westin (BWH)<br />
* Marc Niethammer (PNL)<br />
* Sylvain Bouix (PNL)<br />
<br />
== Discussion overview ==<br />
<br />
'''Statistical shape analysis:'''<br />
<br />
Caudate (SPD):<br />
<br />
* Spherical harmonics for shape description<br />
* local/global/parcellated significance and anlysis<br />
* Local and global differences on R, but only local on L<br />
* main shape difference in caudate head, small effect in caudate tail<br />
* volume reduction in SPD<br />
<br />
Corpus callosum:<br />
<br />
* model based 2D segmentation of corpus callosum<br />
* DTI fiber tracking based corpus callosum subdivision method (coloring based on connection to white matter parcellation -- given as a template) results in probabilistic subdivision of the corpus callosum<br />
<br />
<br /> DTI:<br />
<br />
* quantitative analysis of DTI data (along fibers; statistics within fiber bundles)<br />
<br />
<br />'''PNL provides:'''<br />
<br />
* an interpretation of the shape differences seen in SPD vs control group caudates<br />
* a larger dataset to improve the statistical significance (chronic SZ?)<br />
<br />
<br />'''UNC provides:'''<br />
<br />
* statistical shape analysis software<br />
* fiber viewer and fiber tracking software (in Namic sandbox see also [http://www.ia.unc.edu/dev software here])<br />
* tools for quantitiative analysis of DTI data (statistics of diffusion metrics and tensors along fibers and across fibers within a fiber bundle)<br />
<br />
'''Issues:'''<br />
<br />
* very small sample sizes (-> PNL will provide more and different data)<br />
* local shape difference significance measures are very conservative or not conservative enough (is there a middle groud?)<br />
* not clear how to compare fiber tracts between subjects (how to align?)<br />
<br />
'''Possible future work:'''<br />
<br />
* Do statistical caudate analysis for chronic SZ (expect larger changes than for SPD)?<br />
* Hippocampus study using the UNC software?</div>Andy