DBP2:MIND:BeyondLesionsProject - Revision history

Mscully: /* Key Investigators */

2008-06-27T13:50:29Z

Key Investigators

Hjbockholt: /* Key Investigators */

2008-06-27T13:05:29Z

Key Investigators

Hjbockholt: /* Key Investigators */

2008-06-23T12:19:18Z

Key Investigators

Hjbockholt: /* Key Investigators */

2008-06-23T12:15:47Z

Key Investigators

Hjbockholt: /* Key Investigators */

2008-06-23T12:14:11Z

Key Investigators

Hjbockholt: /* Key Investigators */

2008-06-23T11:31:40Z

Key Investigators

Hjbockholt at 20:52, 22 May 2008

2008-05-22T20:52:43Z

Hjbockholt: /* Key Investigators */

2008-05-22T20:43:29Z

Key Investigators

Hjbockholt at 20:37, 22 May 2008

2008-05-22T20:37:16Z

Hjbockholt: New page: {| |Project Week Main Page ]] |[[Image:genuFAp.jpg|thumb|320px|Scatter plot of the original FA data through ...

2008-05-22T20:29:42Z

New page: {| |thumb|320px|Return to [[2008_Summer_Project_Week|Project Week Main Page ]] |[[Image:genuFAp.jpg|thumb|320px|Scatter plot of the original FA data through ...

New page

{|
|[[Image:ProjectWeek-2008.png|thumb|320px|Return to [[2008_Summer_Project_Week|Project Week Main Page]] ]]
|[[Image:genuFAp.jpg|thumb|320px|Scatter plot of the original FA data through the genu of the corpus callosum of a normal brain.]]
|[[Image:genuFA.jpg|thumb|320px|Regression of FA data; solid line represents the mean and dotted lines the standard deviation.]]
|}

__NOTOC__

===Instructions for Use of this Template===
#Please create a new wiki page with an appropriate title for your project using the convention NA-MIC/Projects/Theme-Name/Project-Name
#Copy the entire text of this page into the page created above
#Link the created page into the list of projects for the project event
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#Send an email to tkapur at bwh.harvard.edu if you are stuck

===Key Investigators===
* UNC: Isabelle Corouge, Casey Goodlett, Guido Gerig
* Utah: Tom Fletcher, Ross Whitaker

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<h1>Objective</h1>
We are developing methods for analyzing diffusion tensor data along fiber tracts. The goal is to be able to make statistical group comparisons with fiber tracts as a common reference frame for comparison.

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<h1>Approach, Plan</h1>

Our approach for analyzing diffusion tensors is summarized in the IPMI 2007 reference below. The main challenge to this approach is <foo>.

Our plan for the project week is to first try out <bar>,...
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<div style="width: 40%; float: left;">

<h1>Progress</h1>

Software for the fiber tracking and statistical analysis along the tracts has been implemented. The statistical methods for diffusion tensors are implemented as ITK code as part of the [[NA-MIC/Projects/Diffusion_Image_Analysis/DTI_Software_and_Algorithm_Infrastructure|DTI Software Infrastructure]] project. The methods have been validated on a repeated scan of a healthy individual. This work has been published as a conference paper (MICCAI 2005) and a journal version (MEDIA 2006). Our recent IPMI 2007 paper includes a nonparametric regression method for analyzing data along a fiber tract.

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===References===
* Fletcher, P.T., Tao, R., Jeong, W.-K., Whitaker, R.T., "A Volumetric Approach to Quantifying Region-to-Region White Matter Connectivity in Diffusion Tensor MRI," to appear Information Processing in Medical Imaging (IPMI) 2007.
* Corouge, I., Fletcher, P.T., Joshi, S., Gilmore, J.H., and Gerig, G., "Fiber Tract-Oriented Statistics for Quantitative Diffusion Tensor MRI Analysis," Medical Image Analysis 10 (2006), 786--798.
* Corouge, I., Fletcher, P.T., Joshi, S., Gilmore J.H., and Gerig, G., Fiber Tract-Oriented Statistics for Quantitative Diffusion Tensor MRI Analysis, Lecture Notes in Computer Science LNCS, James S. Duncan and Guido Gerig, editors, Springer Verlag, Vol. 3749, Oct. 2005, pp. 131 -- 138
* C. Goodlett, I. Corouge, M. Jomier, and G. Gerig, A Quantitative DTI Fiber Tract Analysis Suite, The Insight Journal, vol. ISC/NAMIC/ MICCAI Workshop on Open-Source Software, 2005, Online publication: http://hdl.handle.net/1926/39 .

← Older revision		Revision as of 13:50, 27 June 2008
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	This project was more of a planning session this week.		This project was more of a planning session this week.

		+	Met with Nathan Hageman and discussed some possible approaches to using the scalars, but also potentially using the full eigen-system to analyze multi-direction diffusion.
		+
		+	Introduced to the DTI visualization and analysis capabilities of Slicer along with Nathan's DTI analysis tools.

	</div>		</div>

← Older revision		Revision as of 13:05, 27 June 2008
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	<h1>Progress</h1>		<h1>Progress</h1>
		+	This project was more of a planning session this week.

@@ Line 33: / Line 33: @@
 Map out a strategy and timeline with concrete deliverables for use of DTI scalars.
-Can FA/MD maps contribute favourably to lesion classification?
+Can FA/MD maps contribute favourably to lesion classification or do these maps demonstrate more diffuse white matter abnormalities at and around lesions as identified on FLAIR.
 Set up and run analysis of 42 patients/controls (15 with lesions) to determine if the study replicates lowered FA and highered MD in white matter lesion regions.

@@ Line 32: / Line 32: @@
 <h1>Approach, Plan</h1>
-Map out a strategy and timeline with concrete delivers for use of DTI scalars.
+Map out a strategy and timeline with concrete deliverables for use of DTI scalars.
 Can FA/MD maps contribute favourably to lesion classification?

← Older revision		Revision as of 12:14, 23 June 2008
Line 33:		Line 33:

	Map out a strategy and timeline with concrete delivers for use of DTI scalars.		Map out a strategy and timeline with concrete delivers for use of DTI scalars.
		+	Can FA/MD maps contribute favourably to lesion classification?
		+
		+	Set up and run analysis of 42 patients/controls (15 with lesions) to determine if the study replicates lowered FA and highered MD in white matter lesion regions.
		+
		+
		+
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@@ Line 22: / Line 22: @@
 <h1>Objective</h1>
+Going beyond classification of crisp boundaries of lesion hyperintensities on FLAIR, how can DTI be incorporated to investigate diffuse lesions.
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← Older revision		Revision as of 20:43, 22 May 2008
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	===Key Investigators===		===Key Investigators===
		+	*H. Jeremy Bockholt
		+	*Mark Scully
		+	*Ross Whitaker
		+	*Steve Pieper
		+	*Vincent Magnotta
		+	*Guido Gerig

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 <h1>Progress</h1>
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 ===References===