Projects:ConnectingRegionsOfFunctionalActivation - Revision history

Melonakos at 19:09, 27 November 2007

2007-11-27T19:09:51Z

Melonakos at 13:16, 4 September 2007

2007-09-04T13:16:34Z

Melonakos at 18:50, 3 September 2007

2007-09-03T18:50:53Z

Melonakos at 18:50, 3 September 2007

2007-09-03T18:50:43Z

Melonakos at 16:29, 21 August 2007

2007-08-21T16:29:19Z

Melonakos: NA-MIC/Projects/Diffusion Image Analysis/Connecting Regions of Functional Activation moved to Projects:ConnectingRegionsOfFunctionalActivation

2007-08-21T03:49:26Z

NA-MIC/Projects/Diffusion Image Analysis/Connecting Regions of Functional Activation moved to Projects:ConnectingRegionsOfFunctionalActivation

Tkapur at 15:30, 3 May 2007

2007-05-03T15:30:55Z

Tkapur at 15:30, 3 May 2007

2007-05-03T15:30:27Z

Dougm at 13:37, 19 April 2007

2007-04-19T13:37:51Z

Dougm at 13:37, 19 April 2007

2007-04-19T13:37:40Z

@@ Line 1: / Line 1: @@
 = Connecting Regions Of Functional Activation =
- Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
+Our Objective is to measure, and compare between groups, anatomical connectivity between regions demonstrating functional activation during experiment requiring selection and conflict monitoring.
 [[image:optimalPath.jpg|right|350px]]
-'''Progress'''
+= Description =
 We collected preliminary data using an application of the “optimal path analysis”. In this analysis, we extracted group fMRI activation due to the Stroop effect (attentional experiment where incongruent color, in which the word is written, competes with name of the color itself, activating areas responding to conflict monitoring and selection) separately for controls and schizophrenics. This resulted in three clusters of activation, one in the right Dorsolateral Prefrontal Cortex, a second in the Anterior Cingulate Gyrus, and a third in the Medial Parietal Lobe. In the next step, we placed activation clusters in each individual space, by reversing normalization parameters used during fMRI analysis. Finally, EPI fMRI scans were co-registered to DTI scans, and the same registration parameters were applied to activation maps (fMRI results).
@@ Line 15: / Line 13: @@
 Regions of activation were used as start and destination points for optimal path analysis, which resulted in three separate paths of optimal connectivity for each subject. The probability of the connections were then calculated for each path and each subject, and compared between groups. In our preliminary analysis we included 10 control subjects and 10 chronic schizophrenics. Our results demonstrated a relationship between Stroop Effect fMRI activation in the medial parietal area and optimal path connectivity between parietal and cingulate activation sites in schizophrenics (rho=-0.56; p=0.047), which was not observed in controls. These findings suggest that decreased connectivity may result in schizophrenics relying more on posterior parts of the executive attentional network during performance of the Stroop task.
-''References''
+= Key Investigators =
 * BWH: Marek Kubicki, Lida Ungar, Marc Niethammer, Martha Shenton, Carl-Fredrik Westin

@@ Line 14: / Line 14: @@
 Regions of activation were used as start and destination points for optimal path analysis, which resulted in three separate paths of optimal connectivity for each subject. The probability of the connections were then calculated for each path and each subject, and compared between groups. In our preliminary analysis we included 10 control subjects and 10 chronic schizophrenics. Our results demonstrated a relationship between Stroop Effect fMRI activation in the medial parietal area and optimal path connectivity between parietal and cingulate activation sites in schizophrenics (rho=-0.56; p=0.047), which was not observed in controls. These findings suggest that decreased connectivity may result in schizophrenics relying more on posterior parts of the executive attentional network during performance of the Stroop task.
 '''Key Investigators'''
-*BWH: Marek Kubicki, Lida Ungar, Marc Niethammer, Martha Shenton, Carl-Fredrik Westin
+* BWH: Marek Kubicki, Lida Ungar, Marc Niethammer, Martha Shenton, Carl-Fredrik Westin

← Older revision		Revision as of 18:50, 3 September 2007
Line 4:		Line 4:

	'''Objectives'''		'''Objectives'''
		+
	To measure, and compare between groups, anatomical connectivity between regions demonstrating functional activation during experiment requiring selection and conflict monitoring.		To measure, and compare between groups, anatomical connectivity between regions demonstrating functional activation during experiment requiring selection and conflict monitoring.

@@ Line 1: / Line 1: @@
   Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
-====Objectives:====
+'''Objectives'''
 To measure, and compare between groups, anatomical connectivity between regions demonstrating functional activation during experiment requiring selection and conflict monitoring.
-====Key Investigators:====
+[[image:optimalPath.jpg|right|350px]]
-[[image:optimalPath.jpg|right|350px]]
+'''Progress'''
 We collected preliminary data using an application of the “optimal path analysis”. In this analysis, we extracted group fMRI activation due to the Stroop effect (attentional experiment where incongruent color, in which the word is written, competes with name of the color itself, activating areas responding to conflict monitoring and selection) separately for controls and schizophrenics. This resulted in three clusters of activation, one in the right Dorsolateral Prefrontal Cortex, a second in the Anterior Cingulate Gyrus, and a third in the Medial Parietal Lobe. In the next step, we placed activation clusters in each individual space, by reversing normalization parameters used during fMRI analysis. Finally, EPI fMRI scans were co-registered to DTI scans, and the same registration parameters were applied to activation maps (fMRI results).
 Regions of activation were used as start and destination points for optimal path analysis, which resulted in three separate paths of optimal connectivity for each subject. The probability of the connections were then calculated for each path and each subject, and compared between groups. In our preliminary analysis we included 10 control subjects and 10 chronic schizophrenics. Our results demonstrated a relationship between Stroop Effect fMRI activation in the medial parietal area and optimal path connectivity between parietal and cingulate activation sites in schizophrenics (rho=-0.56; p=0.047), which was not observed in controls. These findings suggest that decreased connectivity may result in schizophrenics relying more on posterior parts of the executive attentional network during performance of the Stroop task.

← Older revision		Revision as of 16:29, 21 August 2007
Line 1:		Line 1:
		+	Back to [[NA-MIC_Collaborations\|NA-MIC_Collaborations]]
		+
	====Objectives:====		====Objectives:====
	To measure, and compare between groups, anatomical connectivity between regions demonstrating functional activation during experiment requiring selection and conflict monitoring.		To measure, and compare between groups, anatomical connectivity between regions demonstrating functional activation during experiment requiring selection and conflict monitoring.

← Older revision	Revision as of 03:49, 21 August 2007
(No difference)

← Older revision		Revision as of 15:30, 3 May 2007
Line 3:		Line 3:

	====Key Investigators:====		====Key Investigators:====
−	*BWH: Marek Kubicki, Lida Ungar, Marc Niethammer, Martha Shenton	+	*BWH: Marek Kubicki, Lida Ungar, Marc Niethammer, Martha Shenton, Carl-Fredrik Westin
−	*MIT: Carl-Fredrik Westin

@@ Line 3: / Line 3: @@
 ====Key Investigators:====
-Harvard PNL: Marek Kubicki, Lida Ungar, Marc Niethammer, Martha Shenton
+*BWH: Marek Kubicki, Lida Ungar, Marc Niethammer, Martha Shenton
-MIT: Carl-Fredrik Westin
+*MIT: Carl-Fredrik Westin

← Older revision		Revision as of 13:37, 19 April 2007
Line 7:		Line 7:


−	[[image:optimalPath.jpg\|right]]	+	[[image:optimalPath.jpg\|right\|350px]]

	====Progress:====		====Progress:====