Projects:DiffusionGraphBasedConnectivity - Revision history

Ipek: /* Description */

2011-10-17T17:33:37Z

Description

Ipek at 17:33, 17 October 2011

2011-10-17T17:33:08Z

Ipek: /* Description */

2011-10-17T17:32:27Z

Description

Ipek: /* Description */

2011-10-17T17:31:46Z

Description

Ipek: /* Key Investigators */

2011-10-17T17:31:26Z

Key Investigators

Ipek: /* Description */

2011-10-17T17:30:35Z

Description

Ipek at 22:15, 1 April 2011

2011-04-01T22:15:05Z

Ipek: /* Description */

2011-04-01T22:11:24Z

Description

Ipek: /* Description */

2011-04-01T22:09:00Z

Description

Ipek: /* Key Investigators */

2011-04-01T22:03:40Z

Key Investigators

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 We are currently working on the application of our algorithm to a publicly available synthetic dataset generated via Numerical Fiber Generator (NFG) (Close et al. A software tool to generate simulated white matter structures for the assessment of fibre-tracking algorithms. NeuroImage (2009) vol. 47 (4) pp. 1288-300). This will allow us to thoroughly evaluate the algorithm as well as compare it to various existing connectivity/tractography methods.
-[[Image:UNC_connectivity_nfg.png|thumb|300px|Application to NFG synthetic data. We start with a complex synthetic dataset, and we compute connectivity maps for each ROI defined by the start/end regions of each fiber bundle. These individual cost maps are compiled into a connectivity matrix that represents the connectivity values between each pair of ROI's. The ROI pairs along the diagonal (marked with a white dot) are the true connections (as given by the ground truth) in the data.]]
+[[Image:UNC_connectivity_nfg.png|thumb|500px|Application to NFG synthetic data. We start with a complex synthetic dataset, and we compute connectivity maps for each ROI defined by the start/end regions of each fiber bundle. These individual cost maps are compiled into a connectivity matrix that represents the connectivity values between each pair of ROI's. The ROI pairs along the diagonal (marked with a white dot) are the true connections (as given by the ground truth) in the data.]]
 = Publications =

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 [[Image:UNC_GraphbasedConnectivity_Ex1.png|thumb|300px|Slicer visualization of genu connectivity map overlaid on streamline genu tracts]]
 Regional connectivity measurements derived from diffusion imaging datasets are of considerable interest in the neuroimaging community for better understanding white matter connectivity. Current connectivity measurements are usually either based on fiber tractography applied in a Monte-Carlo fashion or are variations of the Hamilton-Jacobi approach.
 We propose a novel, graph-based algorithm that provides a fully deterministic, efficient and stable connectivity measure. This method handles crossing fibers and deals well with multiple seed regions. The computation is based on a multi-directional graph propagation algorithm applied to sampled orientation distribution functions computed directly from the original diffusion imaging data. A maximum probability and a minimum cost approach are both possible.
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 We are currently working on the application of our algorithm to a publicly available synthetic dataset generated via Numerical Fiber Generator (NFG) (Close et al. A software tool to generate simulated white matter structures for the assessment of fibre-tracking algorithms. NeuroImage (2009) vol. 47 (4) pp. 1288-300). This will allow us to thoroughly evaluate the algorithm as well as compare it to various existing connectivity/tractography methods.
 [[Image:UNC_connectivity_nfg.png|thumb|300px|Application to NFG synthetic data. We start with a complex synthetic dataset, and we compute connectivity maps for each ROI defined by the start/end regions of each fiber bundle. These individual cost maps are compiled into a connectivity matrix that represents the connectivity values between each pair of ROI's. The ROI pairs along the diagonal (marked with a white dot) are the true connections (as given by the ground truth) in the data.]]

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 [[Image:UNC_GraphbasedConnectivity_Monkeycombined.png|thumb|300px|Average cost map computed on the rhesus monkey DWI atlas with the source located in the internal capsule (left) and the genu of the corpus callosum (right). The grayscale overlays show the FA map, and the 3D visualizations include the streamline tractography results from the same seed regions for comparison purposes.]]
-[[Image:UNC_connectivity_nfg.png|thumb|800px|Application to NFG synthetic data. We start with a complex synthetic dataset, and we compute connectivity maps for each ROI defined by the start/end regions of each fiber bundle. These individual cost maps are compiled into a connectivity matrix that represents the connectivity values between each pair of ROI's. The ROI pairs along the diagonal (marked with a white dot) are the true connections (as given by the ground truth) in the data.]]
 = Publications =

@@ Line 19: / Line 19: @@
 [[Image:UNC_GraphbasedConnectivity_Monkeycombined.png|thumb|300px|Average cost map computed on the rhesus monkey DWI atlas with the source located in the internal capsule (left) and the genu of the corpus callosum (right). The grayscale overlays show the FA map, and the 3D visualizations include the streamline tractography results from the same seed regions for comparison purposes.]]
-[[Image:UNC_connectivity_nfg.png|thumb|1000px|Application to NFG synthetic data. We start with a complex synthetic dataset, and we compute connectivity maps for each ROI defined by the start/end regions of each fiber bundle. These individual cost maps are compiled into a connectivity matrix that represents the connectivity values between each pair of ROI's. The ROI pairs along the diagonal (marked with a white dot) are the true connections (as given by the ground truth) in the data.]]
+[[Image:UNC_connectivity_nfg.png|thumb|800px|Application to NFG synthetic data. We start with a complex synthetic dataset, and we compute connectivity maps for each ROI defined by the start/end regions of each fiber bundle. These individual cost maps are compiled into a connectivity matrix that represents the connectivity values between each pair of ROI's. The ROI pairs along the diagonal (marked with a white dot) are the true connections (as given by the ground truth) in the data.]]
 = Publications =

@@ Line 26: / Line 26: @@
 = Key Investigators =
-* UNC Algorithms: Ipek Oguz, Alexis Boucharin, Yundi Shi, Martin Styner
+* UNC Algorithms: Ipek Oguz, Wenyu Lu, Alexis Boucharin, Yundi Shi, Martin Styner
 = Links =
   [[Category: Diffusion MRI]]

@@ Line 15: / Line 15: @@
 So far we have results on synthetic and limited real datasets to illustrate the potential of our method towards subject-specific connectivity measurements performed in an efficient, stable and reproducible manner. Such individual connectivity measurements would be well suited for studies of neuropathology.
-[[Image:UNC_GraphbasedConnectivity_Monkeycombined.pdf|thumb|300px|Average cost map computed on the rhesus monkey DWI atlas with the source located in the internal capsule (left) and the genu of the corpus callosum (right). The grayscale overlays show the FA map, and the 3D visualizations include the streamline tractography results from the same seed regions for comparison purposes.]]
+[[Image:UNC_GraphbasedConnectivity_Monkeycombined.png|thumb|300px|Average cost map computed on the rhesus monkey DWI atlas with the source located in the internal capsule (left) and the genu of the corpus callosum (right). The grayscale overlays show the FA map, and the 3D visualizations include the streamline tractography results from the same seed regions for comparison purposes.]]
 = Publications =

← Older revision		Revision as of 22:09, 1 April 2011
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	So far we have results on synthetic and limited real datasets to illustrate the potential of our method towards subject-specific connectivity measurements performed in an efficient, stable and reproducible manner. Such individual connectivity measurements would be well suited for studies of neuropathology.		So far we have results on synthetic and limited real datasets to illustrate the potential of our method towards subject-specific connectivity measurements performed in an efficient, stable and reproducible manner. Such individual connectivity measurements would be well suited for studies of neuropathology.
		+
		+	[[Image:UNC_GraphbasedConnectivity_Monkeycombined.pdf\|thumb\|800px\|Average cost map computed on the rhesus monkey DWI atlas with the source located in the internal capsule (left) and the genu of the corpus callosum (right). The grayscale overlays show the FA map, and the 3D visualizations include the streamline tractography results from the same seed regions for comparison purposes.]]

	= Publications =		= Publications =