Projects:InferiorFrontotemporalConnections - Revision history

Melonakos at 18:28, 27 November 2007

2007-11-27T18:28:30Z

Melonakos at 14:22, 4 September 2007

2007-09-04T14:22:15Z

Melonakos at 12:53, 4 September 2007

2007-09-04T12:53:41Z

Melonakos at 02:37, 2 September 2007

2007-09-02T02:37:28Z

Melonakos at 02:37, 2 September 2007

2007-09-02T02:37:12Z

Melonakos at 16:25, 21 August 2007

2007-08-21T16:25:23Z

Melonakos: NA-MIC/Projects/Diffusion Image Analysis/Inferior Frontotemporal Connections moved to Projects:InferiorFrontotemporalConnections

2007-08-21T02:27:45Z

NA-MIC/Projects/Diffusion Image Analysis/Inferior Frontotemporal Connections moved to Projects:InferiorFrontotemporalConnections

Dougm at 13:05, 19 April 2007

2007-04-19T13:05:12Z

Dougm at 13:04, 19 April 2007

2007-04-19T13:04:46Z

Dougm at 13:04, 19 April 2007

2007-04-19T13:04:35Z

@@ Line 1: / Line 1: @@
   Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]], [[Algorithm:MIT|MIT Algorithms]]
-'''Objectives'''
+= Inferior Frontotemporal Connections =
-To use fiber tractography in order to investigate inferior fronto-temporal connections in schizophrenia.
+Our objective is to use fiber tractography in order to investigate inferior fronto-temporal connections in schizophrenia.
-'''Progress'''
+= Description =
 We followed up the ROI analysis of UF in chronic patients, in 27 chronic schizophrenics and 34 controls using a fiber-tracing method to estimate FA along the entire tract. We used two region-of-interest (ROI) extraction method, where we extracted fiber tracts traveling between two, manually drawn ROIs. First ROI was placed in the area previously investigated in our UF paper (Kubicki et al., 2002), second and third ROIs were placed within the temporal pole white matter, and posterior temporal white matter respectively. This resulted in two tracts, both traveling through the temporal stem, but separating their paths shortly after (Uncinate Fasciuclus (UF) and Inferior Occipito-Frontal Fasciuclus (IOFF)).
@@ Line 19: / Line 18: @@
 [[image:frontotemporal_tracts2.jpg]]
-''References''
+= Key Investigators =
 * Harvard PNL: Marek Kubicki, Georgia Bushell, Doug Markant, Marc Niethammer, Martha Shenton
 * MIT: Raul Estapar, Carl-Fredrik Westin

@@ Line 3: / Line 3: @@
   Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]], [[Algorithm:MIT|MIT Algorithms]]
-[[image:frontotemporal.jpg]]
+'''Objectives'''
 To use fiber tractography in order to investigate inferior fronto-temporal connections in schizophrenia.
@@ Line 16: / Line 12: @@
 After fiber tract extraction, we calculated mean FA along the tracts, as well as length, number of fibers and mean curvature of each bundle, and compared them between groups. Post-hoc t-tests revealed that mean FA in patients was not significantly different from controls on either left (P(1,59)=0.900) or right UF (P(1,59)=0.612). IOFF, from the other hand, turned out to be abnormal in schizophrenia on both the left (P(1,59) = 0.019), and right (P(1,59) = 0.031) side, confirming the fiber tractography to be a better tool for tract delineation, and pointing to the need for further investigation in order to fully understand the relationship between this area and schizophrenia abnormalities. In addition, reduced UF integrity, strongly correlated with negative symptoms that often typify social communication disturbance in schizophrenia. Specifically, lower left UF FA correlated with more severe active social avoidance, (rho(25)=-.522, p<.01) as well as lack of spontaneity and flow of conversation rho(26)=-.546, p<.01, while higher symptom ratings indicative of greater severity for anhedonia-asociality correlated significantly with lower right UF integrity (rho(25)=.513, p<.01), as did poorer eye contact with lower right UF integrity (rho(25)=-.597, p<.01).
 [[image:frontotemporal_tracts2.jpg]]
 '''Key Investigators'''

@@ Line 1: / Line 1: @@
 = Inferior Frontotemporal Connections =
-  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
+  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]], [[Algorithm:MIT|MIT Algorithms]]
 [[image:frontotemporal.jpg]]
@@ Line 10: / Line 10: @@
 To use fiber tractography in order to investigate inferior fronto-temporal connections in schizophrenia.
 '''Progress'''
@@ Line 17: / Line 16: @@
 After fiber tract extraction, we calculated mean FA along the tracts, as well as length, number of fibers and mean curvature of each bundle, and compared them between groups. Post-hoc t-tests revealed that mean FA in patients was not significantly different from controls on either left (P(1,59)=0.900) or right UF (P(1,59)=0.612). IOFF, from the other hand, turned out to be abnormal in schizophrenia on both the left (P(1,59) = 0.019), and right (P(1,59) = 0.031) side, confirming the fiber tractography to be a better tool for tract delineation, and pointing to the need for further investigation in order to fully understand the relationship between this area and schizophrenia abnormalities. In addition, reduced UF integrity, strongly correlated with negative symptoms that often typify social communication disturbance in schizophrenia. Specifically, lower left UF FA correlated with more severe active social avoidance, (rho(25)=-.522, p<.01) as well as lack of spontaneity and flow of conversation rho(26)=-.546, p<.01, while higher symptom ratings indicative of greater severity for anhedonia-asociality correlated significantly with lower right UF integrity (rho(25)=.513, p<.01), as did poorer eye contact with lower right UF integrity (rho(25)=-.597, p<.01).
 [[image:frontotemporal_tracts2.jpg]]
@@ Line 23: / Line 21: @@
 '''Key Investigators'''
-Harvard PNL: Marek Kubicki, Georgia Bushell, Doug Markant, Marc Niethammer, Martha Shenton
+* Harvard PNL: Marek Kubicki, Georgia Bushell, Doug Markant, Marc Niethammer, Martha Shenton
-MIT: Raul Estapar, Carl-Fredrik Westin
+'''Links'''

@@ Line 22: / Line 22: @@
 '''Key Investigators'''
 Harvard PNL: Marek Kubicki, Georgia Bushell, Doug Markant, Marc Niethammer, Martha Shenton
 MIT: Raul Estapar, Carl-Fredrik Westin

@@ Line 1: / Line 1: @@
   Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
@@ Line 5: / Line 7: @@
 [[image:frontotemporal_tracts.jpg|400px|right]]
-====Objective:====
+'''Objective'''
 To use fiber tractography in order to investigate inferior fronto-temporal connections in schizophrenia.
-====Progress:====
+'''Progress'''
 We followed up the ROI analysis of UF in chronic patients, in 27 chronic schizophrenics and 34 controls using a fiber-tracing method to estimate FA along the entire tract. We used two region-of-interest (ROI) extraction method, where we extracted fiber tracts traveling between two, manually drawn ROIs. First ROI was placed in the area previously investigated in our UF paper (Kubicki et al., 2002), second and third ROIs were placed within the temporal pole white matter, and posterior temporal white matter respectively. This resulted in two tracts, both traveling through the temporal stem, but separating their paths shortly after (Uncinate Fasciuclus (UF) and Inferior Occipito-Frontal Fasciuclus (IOFF)).
@@ Line 21: / Line 20: @@
 [[image:frontotemporal_tracts2.jpg]]

← Older revision		Revision as of 16:25, 21 August 2007
Line 1:		Line 1:
		+	Back to [[NA-MIC_Collaborations\|NA-MIC_Collaborations]]
		+
	[[image:frontotemporal.jpg]]		[[image:frontotemporal.jpg]]

← Older revision	Revision as of 02:27, 21 August 2007
(No difference)

← Older revision		Revision as of 13:04, 19 April 2007
Line 14:		Line 14:

	We followed up the ROI analysis of UF in chronic patients, in 27 chronic schizophrenics and 34 controls using a fiber-tracing method to estimate FA along the entire tract. We used two region-of-interest (ROI) extraction method, where we extracted fiber tracts traveling between two, manually drawn ROIs. First ROI was placed in the area previously investigated in our UF paper (Kubicki et al., 2002), second and third ROIs were placed within the temporal pole white matter, and posterior temporal white matter respectively. This resulted in two tracts, both traveling through the temporal stem, but separating their paths shortly after (Uncinate Fasciuclus (UF) and Inferior Occipito-Frontal Fasciuclus (IOFF)). After fiber tract extraction, we calculated mean FA along the tracts, as well as length, number of fibers and mean curvature of each bundle, and compared them between groups. Post-hoc t-tests revealed that mean FA in patients was not significantly different from controls on either left (P(1,59)=0.900) or right UF (P(1,59)=0.612). IOFF, from the other hand, turned out to be abnormal in schizophrenia on both the left (P(1,59) = 0.019), and right (P(1,59) = 0.031) side, confirming the fiber tractography to be a better tool for tract delineation, and pointing to the need for further investigation in order to fully understand the relationship between this area and schizophrenia abnormalities. In addition, reduced UF integrity, strongly correlated with negative symptoms that often typify social communication disturbance in schizophrenia. Specifically, lower left UF FA correlated with more severe active social avoidance, (rho(25)=-.522, p<.01) as well as lack of spontaneity and flow of conversation rho(26)=-.546, p<.01, while higher symptom ratings indicative of greater severity for anhedonia-asociality correlated significantly with lower right UF integrity (rho(25)=.513, p<.01), as did poorer eye contact with lower right UF integrity (rho(25)=-.597, p<.01).		We followed up the ROI analysis of UF in chronic patients, in 27 chronic schizophrenics and 34 controls using a fiber-tracing method to estimate FA along the entire tract. We used two region-of-interest (ROI) extraction method, where we extracted fiber tracts traveling between two, manually drawn ROIs. First ROI was placed in the area previously investigated in our UF paper (Kubicki et al., 2002), second and third ROIs were placed within the temporal pole white matter, and posterior temporal white matter respectively. This resulted in two tracts, both traveling through the temporal stem, but separating their paths shortly after (Uncinate Fasciuclus (UF) and Inferior Occipito-Frontal Fasciuclus (IOFF)). After fiber tract extraction, we calculated mean FA along the tracts, as well as length, number of fibers and mean curvature of each bundle, and compared them between groups. Post-hoc t-tests revealed that mean FA in patients was not significantly different from controls on either left (P(1,59)=0.900) or right UF (P(1,59)=0.612). IOFF, from the other hand, turned out to be abnormal in schizophrenia on both the left (P(1,59) = 0.019), and right (P(1,59) = 0.031) side, confirming the fiber tractography to be a better tool for tract delineation, and pointing to the need for further investigation in order to fully understand the relationship between this area and schizophrenia abnormalities. In addition, reduced UF integrity, strongly correlated with negative symptoms that often typify social communication disturbance in schizophrenia. Specifically, lower left UF FA correlated with more severe active social avoidance, (rho(25)=-.522, p<.01) as well as lack of spontaneity and flow of conversation rho(26)=-.546, p<.01, while higher symptom ratings indicative of greater severity for anhedonia-asociality correlated significantly with lower right UF integrity (rho(25)=.513, p<.01), as did poorer eye contact with lower right UF integrity (rho(25)=-.597, p<.01).
		+

	[[image:frontotemporal_tracts2.jpg]]		[[image:frontotemporal_tracts2.jpg]]