Projects:MorphometryFrontalCircuitry - Revision history

Melonakos at 17:13, 12 December 2007

2007-12-12T17:13:20Z

Melonakos at 16:25, 28 November 2007

2007-11-28T16:25:58Z

Melonakos at 13:29, 4 September 2007

2007-09-04T13:29:35Z

Melonakos at 02:06, 4 September 2007

2007-09-04T02:06:00Z

Melonakos at 16:32, 21 August 2007

2007-08-21T16:32:22Z

Melonakos: NA-MIC/Projects/Structural/Morphometric Measures/Schizophrenia/Morphometry Frontal Circuitry moved to Projects:MorphometryFrontalCircuitry

2007-08-21T16:13:29Z

NA-MIC/Projects/Structural/Morphometric Measures/Schizophrenia/Morphometry Frontal Circuitry moved to Projects:MorphometryFrontalCircuitry

Jdwest at 20:09, 3 May 2007

2007-05-03T20:09:24Z

Jdwest at 20:08, 3 May 2007

2007-05-03T20:08:54Z

Jdwest at 19:59, 3 May 2007

2007-05-03T19:59:10Z

Jdwest at 19:58, 3 May 2007

2007-05-03T19:58:22Z

New page

'''Objective:''' To see how morphometry of various frontal circuitry structures relates to substance use disorder.

'''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls. Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.

@@ Line 1: / Line 1: @@
-  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
+  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]], [[DBP1:Dartmouth|Dartmouth DBP 1]]
-__TOC__
+__NOTOC__
 = Morphometry Frontal Circuitry =

@@ Line 1: / Line 1: @@
   Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
-'''Objectives'''
+Our objective is to see how morphometry of various frontal circuitry structures relates to substance use disorder in schizophrenia.
-'''Progress'''
+= Description =
 In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls.  Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.
-''References''
+= Key Investigators =
 * Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister, Nancy Koven
 * Isomics: Steve Pieper

@@ Line 3: / Line 3: @@
   Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
-'''Objective'''
+'''Objectives'''
 To see how morphometry of various frontal circuitry structures relates to substance use disorder in schizophrenia.
@@ Line 10: / Line 10: @@
 In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls.  Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.
 '''Key Investigators'''
@@ Line 15: / Line 17: @@
 * Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister, Nancy Koven
 * Isomics: Steve Pieper

@@ Line 1: / Line 1: @@
   Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
-'''Objective:'''  To see how morphometry of various frontal circuitry structures relates to substance use disorder in schizophrenia.
+'''Objective'''
-'''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls.  Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.
+In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls.  Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.
-'''Key Investigators:'''
+'''Key Investigators'''
 * Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister, Nancy Koven
 * Isomics: Steve Pieper

← Older revision		Revision as of 16:32, 21 August 2007
Line 1:		Line 1:
		+	Back to [[NA-MIC_Collaborations\|NA-MIC_Collaborations]]
		+
	'''Objective:''' To see how morphometry of various frontal circuitry structures relates to substance use disorder in schizophrenia.		'''Objective:''' To see how morphometry of various frontal circuitry structures relates to substance use disorder in schizophrenia.

← Older revision	Revision as of 16:13, 21 August 2007
(No difference)

← Older revision		Revision as of 20:08, 3 May 2007
Line 1:		Line 1:
−	'''Objective:''' To see how morphometry of various frontal circuitry structures relates to substance use disorder.	+	'''Objective:''' To see how morphometry of various frontal circuitry structures relates to substance use disorder in schizophrenia.

	'''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls. Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.		'''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls. Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.

← Older revision		Revision as of 19:59, 3 May 2007
Line 2:		Line 2:

	'''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls. Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.		'''Progress:''' In collaboration with Nancy Koven, Ph.D. at Bates College, we have been conducting volumetric investigations of subregions within brain reward circuitry in healthy adults, patients with schizophrenia and a co-occurring substance use disorder (SUD), and patients with schizophrenia without a history of SUD. 3D-Slicer is being used to trace the nucleus accumbens, orbitofrontal cortex (OFC), and several regions within the anterior cingulate gyrus. With regard to the OFC, preliminary findings on 10 subjects per group indicate that patients with schizophrneia, both with and without co-occurring SUD, have less bilateral OFC volume relative to controls. In comorbid patients, larger right OFC volume was associated with improved inhibitory control on neuropsychological testing. In patients without co-occurring SUD, smaller left OFC volume was associated with poorer inhibitory control. With regard to the anterior cingulate gyrus, analyses indicated that patients with comorbid SUD had smaller bilateral dorsal and rostral subregions relative to healthy controls. Further analysis indicated that patients scored lower on tests of inhhibitory control relative to controls. Test of mediation, however, indicated that dorsal and rostral subregion volumetry did not mediate this neuropsychological dysfunction in this sample.
		+
		+	'''Key Investigators:'''
		+
		+	* Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister
		+	* Isomics: Steve Pieper