Projects:RegistrationLibrary:RegLib C04:About - Revision history

Meier: /* Multiple Sclerosis Natural History Study */

2012-08-13T15:05:44Z

Multiple Sclerosis Natural History Study

Meier at 15:04, 13 August 2012

2012-08-13T15:04:21Z

Meier at 14:59, 13 August 2012

2012-08-13T14:59:28Z

Meier: /* Multiple Sclerosis Natural History Study */

2012-06-22T20:39:19Z

Multiple Sclerosis Natural History Study

Meier: /* Multiple Sclerosis Natural History Study */

2012-06-22T20:36:57Z

Multiple Sclerosis Natural History Study

Meier: /* Multiple Sclerosis Natural History Study */

2012-06-22T20:35:26Z

Multiple Sclerosis Natural History Study

Meier: /* Multiple Sclerosis Natural History Study */

2012-06-22T20:34:45Z

Multiple Sclerosis Natural History Study

Meier: /* Multiple Sclerosis Natural History Study */

2012-06-05T15:49:32Z

Multiple Sclerosis Natural History Study

Meier at 15:49, 5 June 2012

2012-06-05T15:49:01Z

Meier: /* Multiple Sclerosis Natural History Study */

2012-06-05T15:48:07Z

Multiple Sclerosis Natural History Study

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 == Multiple Sclerosis Natural History Study ==
-The images in this case and the time-lapse movie shown below is from a unique longitudinal study, where MS patients underwent weekly to monthly examination including pre- and post-contrast MRI as well as a full clinical evaluation with assessment of clinical disability scores. Because the study was performed before effective disease-modifying treatments became available, it represents a unique snapshot of the natural history of MS that can no longer be reproduced today.  The full power of this dataset on visualizing the unique dynamics of MS becomes apparent only after extensive preprocessing that involves spatial registration, intensity-normalization, partial volume filtering and other corrections.
+The images in this case and the time-lapse movie shown below is from a unique longitudinal study, where MS patients underwent weekly to monthly examination including pre- and post-contrast MRI as well as a full clinical evaluation with assessment of clinical disability scores. Because the study was performed before effective disease-modifying treatments became available, it represents a unique snapshot of the natural history of MS that can no longer be reproduced today.  The full power of this dataset on visualizing the unique dynamics of MS becomes apparent only after extensive preprocessing that involves spatial registration, intensity-normalization, partial volume filtering and other corrections. On average 25 separate exams were co-registered for each movie shown.
 '''You will find more details in the following articles in the SPL publication database:'''
 :1.[http://www.spl.harvard.edu/publications/item/view/1907 Seasonal Prevalence of MS Disease Activity. Neurology 2010]

@@ Line 11: / Line 11: @@
 ----
 [[Image:MGrid_crop1_full.gif|Example time lapse of a single MS patient of the course of 1 year]]
 [[Image:TSAGif_Recov.gif|Example time lapse animation of a single lesion showing significant recovery]]
 [[Image:TSAGif_NoRecov.gif|Example time lapse animation of a single lesion showing little to no recovery]]
 [[Image:TSAGif_Prop.gif|Example time lapse animation of a single lesion showing propagation along the WM]]

← Older revision		Revision as of 14:59, 13 August 2012
Line 11:		Line 11:
	----		----
	[[Image:MGrid_crop1_full.gif\|Example time lapse of a single MS patient of the course of 1 year]]		[[Image:MGrid_crop1_full.gif\|Example time lapse of a single MS patient of the course of 1 year]]
		+	[[Image:TSAGif_Recov.gif\|Example time lapse animation of a single lesion showing significant recovery]]
		+	[[Image:TSAGif_NoRecov.gif\|Example time lapse animation of a single lesion showing little to no recovery]]
		+	[[Image:TSAGif_Prop.gif\|Example time lapse animation of a single lesion showing propagation along the WM]]

@@ Line 8: / Line 8: @@
 :5.[http://www.spl.harvard.edu/publications/item/view/185 Time-series Analysis of MRI Intensity Patterns in Multiple Sclerosis. NeuroImage 2003]
-For presentations including the animation below please cite:
+For presentations including the animation below please cite [http://www.spl.harvard.edu/publications/item/view/185 Meier et al. , ''NeuroImage'' 2003;  20(2):1193-209.] for the image analysis methodology and [http://www.ncbi.nlm.nih.gov/pubmed/10713356 Weiner et al. , ''J Neuroimmunol''  2000; 104(2):164-73.] for the data origin.
 ----
 [[Image:MGrid_crop1_full.gif|Example time lapse of a single MS patient of the course of 1 year]]

@@ Line 9: / Line 9: @@
 For presentations including the animation below please cite:
-*[http://www.spl.harvard.edu/publications/item/view/185 Meier et al. , ''NeuroImage'' 2003;  20(2):1193-209.]
+*[http://www.spl.harvard.edu/publications/item/view/185 Meier et al. , ''NeuroImage'' 2003;  20(2):1193-209.] for the image analysis methodology and [http://www.ncbi.nlm.nih.gov/pubmed/10713356 Weiner et al. , ''J Neuroimmunol''  2000; 104(2):164-73.] for the data origin.
 ----
 [[Image:MGrid_crop1_full.gif|Example time lapse of a single MS patient of the course of 1 year]]

@@ Line 1: / Line 1: @@
 == Multiple Sclerosis Natural History Study ==
 The images in this case and the time-lapse movie shown below is from a unique longitudinal study, where MS patients underwent weekly to monthly examination including pre- and post-contrast MRI as well as a full clinical evaluation with assessment of clinical disability scores. Because the study was performed before effective disease-modifying treatments became available, it represents a unique snapshot of the natural history of MS that can no longer be reproduced today.  The full power of this dataset on visualizing the unique dynamics of MS becomes apparent only after extensive preprocessing that involves spatial registration, intensity-normalization, partial volume filtering and other corrections.
-'''For more details see the SPL publication database:'''
+'''You will find more details in the following articles in the SPL publication database:'''
-*[http://www.spl.harvard.edu/publications/item/view/1907 Seasonal Prevalence of MS Disease Activity. Neurology 2010]
+:1.[http://www.spl.harvard.edu/publications/item/view/1907 Seasonal Prevalence of MS Disease Activity. Neurology 2010]
-*[http://www.spl.harvard.edu/publications/item/view/1172 MR Imaging Intensity Modeling of Damage and Repair In Multiple Sclerosis: Relationship of Short-Term Lesion Recovery to Progression and Disability. AJNR 2007]
+:2.[http://www.spl.harvard.edu/publications/item/view/1172 MR Imaging Intensity Modeling of Damage and Repair In Multiple Sclerosis: Relationship of Short-Term Lesion Recovery to Progression and Disability. AJNR 2007]
-*[http://www.spl.harvard.edu/publications/item/view/564 Time-series Modeling of Multiple Sclerosis Disease Activity: A Promising Window on Disease Progression and Repair Potential? Neurotherapeutics. 2007]
+:3.[http://www.spl.harvard.edu/publications/item/view/564 Time-series Modeling of Multiple Sclerosis Disease Activity: A Promising Window on Disease Progression and Repair Potential? Neurotherapeutics. 2007]
-*[http://www.spl.harvard.edu/publications/item/view/87 MRI Time Series Modeling of MS Lesion Development. NeuroImage 2006]
+:4.[http://www.spl.harvard.edu/publications/item/view/87 MRI Time Series Modeling of MS Lesion Development. NeuroImage 2006]
-*[http://www.spl.harvard.edu/publications/item/view/185 Time-series Analysis of MRI Intensity Patterns in Multiple Sclerosis. NeuroImage 2003]
+:5.[http://www.spl.harvard.edu/publications/item/view/185 Time-series Analysis of MRI Intensity Patterns in Multiple Sclerosis. NeuroImage 2003]
 ----
 [[Image:MGrid_crop1_full.gif|Example time lapse of a single MS patient of the course of 1 year]]

← Older revision		Revision as of 15:49, 5 June 2012
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−	[[Image:MGrid_crop1_full.gif~~\|400px~~\|Example time lapse of a single MS patient of the course of 1 year]]	+	[[Image:MGrid_crop1_full.gif\|Example time lapse of a single MS patient of the course of 1 year]]