Difference between revisions of "2011 Summer Project Week Quantitative Magnetic Susceptibility Mapping"

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'''Full Title of Project'''
 
'''Full Title of Project'''
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Quantitative Magnetic Susceptibility Mapping
  
 
==Key Investigators==
 
==Key Investigators==
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* Utah: Bo Wang, Marcel Prastawa, Guido Gerig
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* MIT: Clare Poynton
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* UCLA: Jack Van Horn, Andrei Irimia, Micah Chambers
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* BWH: Sandy Wells
  
  
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<h3>Objective</h3>
 
<h3>Objective</h3>
  
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Traumatic brain injury (TBI) occurs when an external force traumatically injures the brain. It is a driving biological problem (DBP) in NA-MIC.
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Quantifying magnetic susceptibility in the brain from the phase of the MR signal provides a non-invasive means for measuring the
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TBI is a major cause of death and disability worldwide, especially in children and young adults.  
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accumulation of iron believed to occur with aging and neurodegenerative disease.
  
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We're working on the supervised segmentation and atlas optimization of longitudinal TBI data.
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We describe a variational approach to susceptibility estimation that incorporates a tissue-air atlas to resolve ambiguity
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in the susceptibility estimates, while eliminating additional biasfi�elds through application of the Laplacian.  
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On anatomical MRI scans, to quantitatively analyze the cortical thickness, white matter changes, we need to have a good segmentation on TBI images. However, for TBI data, standard automated image analysis methods are not robust with respect to the TBI-related changes in image contrast, changes in brain shape, cranial fractures, white matter fiber alterations, and other signatures of head injury.  
 
  
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Results show qualitative improvement over two methods commonly used to infer underlying susceptibility values,
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and quantitative susceptibility estimates show better correlation with postmortem iron concentrations than competing methods.
  
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The goal for this week is to apply this method to evaluate magnetic susceptibility of lesions associated with TBI.
  
 
</div>
 
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<h3>Approach, Plan</h3>
 
<h3>Approach, Plan</h3>
 
Our plan for the project week:
 
Our plan for the project week:
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* Test our preliminary code
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* Discuss applications with collaborators and try to refine the algorithm
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* Discuss with collaborators and try to refine the algorithm
 
  
 
</div>
 
</div>
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==References==
 
==References==
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* [http://www.nitrc.org/projects/abc ABC]
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* [http://www.na-mic.org/Wiki/index.php/DBP3:UCLA Traumatic brain injury (TBI)]
 
 
</div>
 
</div>

Revision as of 17:32, 20 June 2011

Home < 2011 Summer Project Week Quantitative Magnetic Susceptibility Mapping



Full Title of Project

Quantitative Magnetic Susceptibility Mapping

Key Investigators

  • MIT: Clare Poynton
  • BWH: Sandy Wells


Objective

Quantifying magnetic susceptibility in the brain from the phase of the MR signal provides a non-invasive means for measuring the accumulation of iron believed to occur with aging and neurodegenerative disease.

We describe a variational approach to susceptibility estimation that incorporates a tissue-air atlas to resolve ambiguity in the susceptibility estimates, while eliminating additional biasfi�elds through application of the Laplacian.

Results show qualitative improvement over two methods commonly used to infer underlying susceptibility values, and quantitative susceptibility estimates show better correlation with postmortem iron concentrations than competing methods.

The goal for this week is to apply this method to evaluate magnetic susceptibility of lesions associated with TBI.

Approach, Plan

Our plan for the project week:

  • Discuss applications with collaborators and try to refine the algorithm

Progress


References

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