2011 Summer Project Week Quantitative Magnetic Susceptibility Mapping

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Full Title of Project

Quantitative Magnetic Susceptibility Mapping

Key Investigators

  • MIT: Clare Poynton
  • BWH: Sandy Wells


Objective

Quantifying magnetic susceptibility in the brain from the phase of the MR signal provides a non-invasive means for measuring the accumulation of iron believed to occur with aging and neurodegenerative disease.

We describe a variational approach to susceptibility estimation that incorporates a tissue-air atlas to resolve ambiguity in the susceptibility estimates, while eliminating additional biasfields through application of the Laplacian.

Results show qualitative improvement over two methods commonly used to infer underlying susceptibility values, and quantitative susceptibility estimates show better correlation with postmortem iron concentrations than competing methods.

The goal for this week is to apply this method to evaluate magnetic susceptibility of lesions associated with TBI.

Approach, Plan

Our plan for the project week:

  • Discuss applications with collaborators and try to refine the algorithm

Progress


References