2014 Summer Project Week:Stroke-ImagingGenetics

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  Projects List

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  Clinical Stroke Image

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  Leukoaraiosis Model

Key Investigators

• Adrian Dalca, Ramesh Sridharan, Polina Golland, MIT
• Natalia Rost, Jonathan Rosand, MGH

Project Description

This is one of a series of projects on a large clinical dataset of stroke patients, including T2-FLAIR and DWI imaging. We recently (MICCAI 2014) developed a leukoaraiosis (small vessel disease) probabilistic co-variation model, which we use to differentiate between small vessel disease and acute or chronic stroke on T2-FLAIR.

Average Leukoaraiosis projection

Explore the first component of the model

Objective

• Here, we wish to investigate the parameters of the model as potential phenotypes against for clinical and genetic analyses.

Approach, Plan

• We will create the phenotype projections for ~80 stroke patients and experiment with correlating the genetic and clinical factors.

Progress