2014 Summer Project Week:Stroke-ImagingGenetics

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  Projects List

Key Investigators

- Adrian Dalca, Ramesh Sridharan, Polina Golland, MIT

- Natalia Rost, Jonathan Rosand, MGH

Project Description

We recently (MICCAI 2014) developed a leukoaraiosis (small vessel disease) probabilistic co-variation model, which we use to differentiate between small vessel disease and acute or chronic stroke on T2-FLAIR.

<a href="http://www.mit.edu/~adalca/tipiXnightly/?path=http://people.csail.mit.edu/adalca/stroke/tipix/mean_leuk/mainSubVol__$.png&xBins=256&nDims=1&debug=true"> Average Leukoaraiosis projection </a>

<a href="http://www.mit.edu/~adalca/tipiXnightly/?path=http://people.csail.mit.edu/adalca/stroke/tipix/leuk_span/x_$.nii.gz&xBins=1&nDims=1&debug=true"> Explore the first component of the model </a>

Objective

• Here, we wish to investigate the parameters of the model as potential phenotypes against for clinical and genetic analyses.

Approach, Plan

• We will create the phenotype projections for ~80 stroke patients and experiment with correlating the genetic and clinical factors.

Progress