CTSC:MGHresources:The Mouse Imaging Program

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The Mouse Imaging Program (MIP) is a large scale imaging resource supported in part through an NCI U24 grant. The resource provides the larger Harvard/MIT research community with access to state-of-the-art in vivo imaging technologies. The program offers high resolution magnetic resonance (MR), positron emission tomography (PET-CT), single photon emission computed tomography (SPECT-CT), computed tomography (CT), fluorescence mediated tomography (FMT), bioluminescence (BLI), and various other fluorescence imaging technologies. The integrated program also provides mouse holding facilities for serial imaging, surgery, anesthesia, veterinary care and imaging agents. Image reconstruction, 3D display, fusion, quantitative image analysis and server access are also available. The program offers periodic training and performs its own research to continuously improve existing imaging technologies. Imaging requests from investigators of the Mouse Model of Human Cancers Consortia and recipients of NCI grants are prioritized.

  • Magnetic Resonance Imaging (MRI)

The overall goal of the MRI facility is provide high resolution/high throughput imaging capabilities and equipment/pulse sequences that deliver sufficient SNR to test novel molecularly targeted MR imaging agents. Two high field magnets operate at 4.7 Tesla and 7 Tesla fieldstrength, providing the optimal setup to image both T1 and T2/T2* targeting imaging probes. In addition, the magnets facilitate state of the art high resolution anatomical and functional imaging of various mouse models in cancer, cardiovascular and neuro-research. We use tailored MR pulse sequences and high-end, dedicated RF coils, ranging in size from rat whole body to mouse heart, to optimize SNR for specific application. To assure imaging at physiologic conditions and to optimize anesthesia, dedicated monitoring systems are capable of recording the heart and respiratory rate and body temperature, which is kept in a physiological range by MR compatible heating systems.