CTSC:education Quantitative Imaging Biomarkers

• Dr Kasia Macura, Johns Hopkins [[media: macura.pdf| Overview of imaging biomarkers and their use in clinical trials
• Dr Randy Gollub, Harvard MGH Generic principles of image registration, segmentation, visualization (technical aspects)
• Dr Jeff Yap, Harvard DFCI Description and case studies of each of the imaging biomarkers and requirements for standardized acquisition in multi-center trials (e.g. RSNA QIBA)
  • DCE-MRI (pre/post-therapy breast tumor perfusion)
  • volumetric CT (e.g. lung tumor segmentation and volumetric measurement)
  • FDG-PET/CT (pre/post-therapy whole-body imaging with SUV quantification)