Difference between revisions of "Collaboration/WFU/NonHuman Primate Neuroimaging"

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{|
=Additional Information=
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|[[Image:ProjectWeek-2007.png|thumb|320px|Return to [[2007_Programming/Project_Week_MIT|Project Week Main Page]] ]]
Please link to pages with additional information here.
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__NOTOC__
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===Key Investigators===
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* VT: Chris Wyatt
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* BWH: Kilian Pohl
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<div style="margin: 20px;">
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<div style="width: 27%; float: left; padding-right: 3%;">
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<h1>Objective</h1>
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The objectives of this project are to:
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# Optimize the EM Brain Classifier in Slicer on MRI images of rhesus macaques
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# Develop a custom GM/WM/CSF atlas, bootstrapping from one provided by Martin Styner
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# Integrate a sub-cortical atlas
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# Segment data from N subjects in the alcohol naive and post-induction state.
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# Compare GM/WM volume and ratios between the two states
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# Compare hippocampus, putamen, and caudate volumes between states
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</div>
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<div style="width: 27%; float: left; padding-right: 3%;">
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<h1>Approach, Plan</h1>
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We will use the current implementation of the EM Brain classifier in slicer. Using a manual segmentation as an estimate of ground truth in a single subject, we will optimize the EM segmenter parameters over the classification error and running time. The study will be run via VPN on a Sungrid at VT.
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</div>
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<div style="width: 40%; float: left;">
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<h1>Progress</h1>
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</div>
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<br style="clear: both;" />
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</div>
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===References===
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* K. M. Pohl, J. Fisher, W.E.L. Grimson, R. Kikinis, and W.M. Wells. A Bayesian Model for Joint Segmentation and Registration. NeuroImage, 31(1), pp. 228-239, 2006.
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* E. V. Sullivan, H. J. Sable, W. N Strother, D. P. Friedman, A. Davenport, H. Tillman-Smith, R. A. Kraft, C. L. Wyatt, K. T. Szeliga, N. C. Buchheimer, J. B. Daunais, E. Adalsteinsson, A. Pfefferbaum, K. A Grant, Neuroimaging of Rodent and Primate Models of Alcoholism: Initial Reports from the Integrative Neuroscience Initiative on Alcoholism, Alcoholism: Clinical and Experimental Research Vol. 29 No. 2 pgs 287-294 Feb 2005.

Revision as of 12:31, 31 May 2007

Home < Collaboration < WFU < NonHuman Primate Neuroimaging


Key Investigators

  • VT: Chris Wyatt
  • BWH: Kilian Pohl


Objective

The objectives of this project are to:

  1. Optimize the EM Brain Classifier in Slicer on MRI images of rhesus macaques
  2. Develop a custom GM/WM/CSF atlas, bootstrapping from one provided by Martin Styner
  3. Integrate a sub-cortical atlas
  4. Segment data from N subjects in the alcohol naive and post-induction state.
  5. Compare GM/WM volume and ratios between the two states
  6. Compare hippocampus, putamen, and caudate volumes between states


Approach, Plan

We will use the current implementation of the EM Brain classifier in slicer. Using a manual segmentation as an estimate of ground truth in a single subject, we will optimize the EM segmenter parameters over the classification error and running time. The study will be run via VPN on a Sungrid at VT.

Progress




References

  • K. M. Pohl, J. Fisher, W.E.L. Grimson, R. Kikinis, and W.M. Wells. A Bayesian Model for Joint Segmentation and Registration. NeuroImage, 31(1), pp. 228-239, 2006.
  • E. V. Sullivan, H. J. Sable, W. N Strother, D. P. Friedman, A. Davenport, H. Tillman-Smith, R. A. Kraft, C. L. Wyatt, K. T. Szeliga, N. C. Buchheimer, J. B. Daunais, E. Adalsteinsson, A. Pfefferbaum, K. A Grant, Neuroimaging of Rodent and Primate Models of Alcoholism: Initial Reports from the Integrative Neuroscience Initiative on Alcoholism, Alcoholism: Clinical and Experimental Research Vol. 29 No. 2 pgs 287-294 Feb 2005.