Difference between revisions of "Collaboration:NCMIR Microscopy"

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Back to [[NA-MIC_External_Collaborations|NA-MIC External Collaborations]]
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__NOTOC__
 
== Background ==
 
== Background ==
  
 
[[Image:Spines01.jpg|thumb|125px|A small fragment of a dendrite (gray) with segmented spines (color).]]
 
[[Image:Spines01.jpg|thumb|125px|A small fragment of a dendrite (gray) with segmented spines (color).]]
  
* The collaboration in regards to Microscopy was fostered through a supplement to the National Center for Microscopy and Imaging Research (NCMIR; http://ncmir.ucsd.edu) at the University of California, San Diego. A key emphasis of NCMIR is the application of advanced imaging technologies to the nervous system in health and disease. Affiliated with UCSD’s Center for Research in Biological Systems (CRBS), the NCMIR is a recognized authority in the development of technologies for high throughput multi-scale imaging and analysis of biological systems at the mesoscale, the dimensional range spanning 5 nm3 and 50µm3. Macromolecules, organelles, and multi-component structures like synapses which are encompassed in this dimensional range have traditionally been challenging to study because they fall in the resolution gap between X-ray crystallography at one end and medical imaging at the other.
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* The collaboration in regards to Microscopy was fostered through a supplement, funding now completed, to the National Center for Microscopy and Imaging Research (NCMIR; http://ncmir.ucsd.edu) at the University of California, San Diego. A key emphasis of NCMIR is the application of advanced imaging technologies to the nervous system in health and disease. Affiliated with UCSD’s Center for Research in Biological Systems (CRBS), the NCMIR is a recognized authority in the development of technologies for high throughput multi-scale imaging and analysis of biological systems at the mesoscale, the dimensional range spanning 5nm<sup>3</sup> and 50µm<sup>3</sup>. Macromolecules, organelles, and multi-component structures like synapses which are encompassed in this dimensional range have traditionally been challenging to study because they fall in the resolution gap between X-ray crystallography at one end and medical imaging at the other.
  
* Work within the Slicer environment to address multi-scale microscopy imaging data, thereby allowing for the analysis and visualization of cellular data.  The project has focused on the importation of data into Slicer and the investigation of algorithms for cellular and sub-cellular data (e.g. see -  http://www.na-mic.org/Wiki/index.php/Projects/Slicer3/2007_Project_Week_Support_for_electron_microscopy).
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* Work, as part of this collaboration, focused on requirements and extensions for the Slicer environment to address multi-scale microscopy imaging data, thereby allowing for the analysis and visualization of cellular data.  The project has focused on the importation of data into Slicer and the investigation of algorithms for cellular and sub-cellular data (e.g. see -  http://www.na-mic.org/Wiki/index.php/Projects/Slicer3/2007_Project_Week_Support_for_electron_microscopy).
  
== Using Slicer for Microscopy ==
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== Delivered Using Slicer for Microscopy Tutorial ==
 
[[Image:MicroscopyTutorialSlide.jpg|thumb|200px|A slide from the Microscopy tutorial developed through this collaboration.]]
 
[[Image:MicroscopyTutorialSlide.jpg|thumb|200px|A slide from the Microscopy tutorial developed through this collaboration.]]
  
 
* A direct result of this collaboration was the tutorial developed by UCSD for use of Slicer with confocal microscopy data: "Guiding you step by step through the process of loading confocal microscopy data, working with that data, and creating a 3D model for visualization."  The tutorial covers the complete use of Slicer from loading data (including the downloading of data from publicly available open-source repositories), visualization of data and basic editing with the editor module.  The tutorial then covers model building using basic slicer modules and the Otsu segmentation module.
 
* A direct result of this collaboration was the tutorial developed by UCSD for use of Slicer with confocal microscopy data: "Guiding you step by step through the process of loading confocal microscopy data, working with that data, and creating a 3D model for visualization."  The tutorial covers the complete use of Slicer from loading data (including the downloading of data from publicly available open-source repositories), visualization of data and basic editing with the editor module.  The tutorial then covers model building using basic slicer modules and the Otsu segmentation module.
  
* This tutorial won the 2009 Summer Programming Week Tutorial contest (see - http://www.na-mic.org/Wiki/index.php/Events:TutorialContestJune2009Summer).  
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* This tutorial won the 2009 Summer Programming Week [http://www.na-mic.org/Wiki/index.php/Events:TutorialContestJune2009 Tutorial Contest].  
  
 
* [[media:Microscopy-Confocal-TrainingTutorial-2009JUNE.pdf|Confocal Microscopy Tutorial]]
 
* [[media:Microscopy-Confocal-TrainingTutorial-2009JUNE.pdf|Confocal Microscopy Tutorial]]
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==Grant#==
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U54EB005149-05S3
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==Key Personnel==
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*UCSD: Jeffrey S. Grethe
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*NA-MIC: Bryan Smith
  
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==Grant Duration==
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08/01/2006-07/31/2008
 
== Contact ==
 
== Contact ==
  
 
* Mark Ellisman (mark at ncmir.ucsd.edu)
 
* Mark Ellisman (mark at ncmir.ucsd.edu)
 
* Jeffrey Grethe (jgrethe at ncmir.ucsd.edu)
 
* Jeffrey Grethe (jgrethe at ncmir.ucsd.edu)

Latest revision as of 19:42, 16 December 2009

Home < Collaboration:NCMIR Microscopy

Back to NA-MIC External Collaborations

Background

A small fragment of a dendrite (gray) with segmented spines (color).
  • The collaboration in regards to Microscopy was fostered through a supplement, funding now completed, to the National Center for Microscopy and Imaging Research (NCMIR; http://ncmir.ucsd.edu) at the University of California, San Diego. A key emphasis of NCMIR is the application of advanced imaging technologies to the nervous system in health and disease. Affiliated with UCSD’s Center for Research in Biological Systems (CRBS), the NCMIR is a recognized authority in the development of technologies for high throughput multi-scale imaging and analysis of biological systems at the mesoscale, the dimensional range spanning 5nm3 and 50µm3. Macromolecules, organelles, and multi-component structures like synapses which are encompassed in this dimensional range have traditionally been challenging to study because they fall in the resolution gap between X-ray crystallography at one end and medical imaging at the other.

Delivered Using Slicer for Microscopy Tutorial

A slide from the Microscopy tutorial developed through this collaboration.
  • A direct result of this collaboration was the tutorial developed by UCSD for use of Slicer with confocal microscopy data: "Guiding you step by step through the process of loading confocal microscopy data, working with that data, and creating a 3D model for visualization." The tutorial covers the complete use of Slicer from loading data (including the downloading of data from publicly available open-source repositories), visualization of data and basic editing with the editor module. The tutorial then covers model building using basic slicer modules and the Otsu segmentation module.

Grant#

U54EB005149-05S3

Key Personnel

  • UCSD: Jeffrey S. Grethe
  • NA-MIC: Bryan Smith

Grant Duration

08/01/2006-07/31/2008

Contact

  • Mark Ellisman (mark at ncmir.ucsd.edu)
  • Jeffrey Grethe (jgrethe at ncmir.ucsd.edu)