DBP2:MIND:Roadmap
Brain Lesion Analysis in Neuropsychiatric Systemic Lupus Erythematosus
Compare Lesion Analysis Tools
A number of algorithms for fully or semi-automated lesion analysis will be evaluated on brain images from subjects in a study on lupus erythematosis. These include:
1) The tools developed by the UNC group
2) The tools developed by the BWH group
3) Tools within Medx
4) BRAINS2
5) manual tracing
Data will be collected at both 1.5 and 3T. Data at 1.5T will be obtained with the protocol utilized for current project on lupus at UNM.
Data at 3T will be obtained with sequences optimized for segmentation by the group at Utah.
Comparisons will be based on the approach developed by Martin-Fernandez et al.
Incorporation into Slicer
The algorithm with the best performance will be incorporated in Slicer3.
Tutorial
Documentation will be written for a tutorial and sample data sets will be provided
Longitudinal studies
Tools will be developed for comparing differences in lesion number, size, and location with time.