DBP3:MGH

Project plan for NA-MIC DBP on adaptive radiotherapy (MGH)

http://www.na-mic.org/pages/DBP:Head_and_Neck_Cancer

DBP Science

• Goal: Scientific evidence for or against adaptive proton-beam radiotherapy in the base of skull region
• Require: Update literature review
• Recommend: Study to quantify geometry of anatomic differences
• Require: Comparison study of delivered vs. planned dose
• Require: Comparison study of delivered vs. adaptive dose
• Wishlist: Comparison study of IMRT vs. protons

Image Registration

• Goal: Multiple slicer plugins for registration
• Recommend: Experimental evaluation of existing registration methods
• Require: Interactive registration (landmark splines)
• Recommend: Regularized B-splines
• Recommend: B-splines with landmark constraints
• Recommend: B-splines with surface constraints
• Wishlist: Parameter-free registration
• Wishlist: Image-free surface registration
• Wishlist: Parallel optimization

Image Segmentation

• Goal: Slicer plugin for automatic segmentation
• Require: Contour propagation for intra-subject segmentation
• Recommend: Automatic segmentation (atlas-based) for inter-subject segmentation
• Recommend: Automatic segmentation (model-based) for inter-subject segmentation
• Wishlist: Contour interpolation methods for interactive segmentation

Radiotherapy Workflow

• Goal: Reasonably complete workflow, including dose review and comparison tools
• Require: Labelmap that can handle overlapping structures
• Require: Visualization of RT dose (2D, as isodose lines, with legend)
• Wishlist: Visualization of RT dose (3D, w/ Shadie)
• Require: DICOM improvements (CT export, DICOM-RT import/export)
• Require: Compute dose volume histograms
• Recommend: Margin tools
• Wishlist: Visualize dose volume histograms
• Require: Better support for extensions
• Recommend: MRML node for registration
• Recommend: MRML node for patient demographics
• Wishlist: Unevely spaced CT
• Wishlist: Vector field visualization
• Wishlist: DICOM Network I/O

Data

• Goal: 50 cases for inter-subject segmentation
• Goal: 30 cases for intra-subject registration
• Require: New retrospective IRB
• Require: Careful QA of segmentation data
• Require: Validation data for registration studies

Outreach

• Require: Symposium or tutorial at major conference
• Require: Hands-on tutorial at MGH
• Require: On-line tutorials for radiotherapy workflow
• Recommend: User's group meeting at major conference