Difference between revisions of "DBP3:Utah:RegCases"

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== Registration Case Types ==
 
== Registration Case Types ==
  
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=== Pre-ablation LGE to 3 months (or more) post-ablation LGE ===
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=== Pre to Post LGE-MRI ===
  
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* Examine the location of ablation-induced scar formation relative to fibrosis
 
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* Utah score staging of patients [http://www.healthsciences.utah.edu/carma/images/Publications/Akoum2011.pdf]
 
  
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=== Pre-ablation LGE to Immediately post-ablation(IPA) LGE ===
 
  
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* Can compare acute ablation-induced changes to the pre-ablation tissue
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=== Pre to Pre LGE-MRI ===
  
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=== Immediately post-ablation to 3 months (or more) post-ablation LGE ===
 
  
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* Dark regions on IPA LGE scans result in stable scar formation at 3 or more months post-ablation -> [http://www.sci.utah.edu/~prastawa/papers/JACC2011_McGann_PredictAfibScar.pdf]
 
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* Look for gaps in the ablation lesion sets - Ravi's project
 
  
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=== Post-ablation LGE to Post-ablation LGE ===
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=== Post to Post LGE-MRI ===
  
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* Comparing the outcome of repeated ablation procedures to the
 
  
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=== Pre-ablation LGE to Pre-ablation LGE ===
 
  
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* Comparison across patients prior to ablation
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=== MRA to LGE-MRI ===
  
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=== LGE to Dark-blood MRI ===
 
  
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* Dark blood images can be used to detect early lesion formation
 
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* Can compare with lesion formation seen later on LGE images
 
  
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=== LGE to MRA ===
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=== MRA to MRA ===
  
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* The boundaries of the LA in the MRA mirror the endocardial surface in the LGE scans
 
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* There is the possibility for thresholding the MRA and then registering the segmented region to the LGE
 
  
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=== LGE to Electroanatomic map (Carto) ===
 
  
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* Compare the low voltage regions of Carto maps to the LGE scans
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=== Immediately-Post  to Post LGE-MRI ===
  
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=== LGE to CT ===
 
  
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* Align LGE and CT for those few patients that have both
 
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* Possibly helpful for correlating volumes and shape in shape analysis studies
 
  
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=== Pre-ablation LGE/Endo to Post-ablation LGE/Endo ===
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=== CT to LGE-MRI ===
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=== Vector-Valued Registration ===
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* Combined the LGE images and manual segmentations can be used to improve the quality of registration
 
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* Yi Gao previously developed a Slicer module to register pre- and post-ablation images driven by the LGE images/segmentations -> [[Projects:AFibSegmentationRegistration#Registration|AFib Registration]] & [[DBP3:Utah:VecReg|AFib Registration Examples]]
 
  
  

Revision as of 22:24, 9 May 2012

Home < DBP3:Utah:RegCases

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Background

  • The CARMA Center uses late gadolinium enhanced MRI (LGE-MRI) images to evaluate new patients, predict procedural success, and evaluate therapeutic outcomes. The MRI images for each patient are further accompanied by MR angiographic images (MRA) and manual segmentations of relevant structures. These images are acquired longitudinally over the course of a patient's evaluation, treatment, and follow-up (i.e. months or years). Registration is often necessary to compare images from different time points in a patient's treatment, across patient cohorts at the same stage of disease progression or treatment, or different image types.
Pre-ablation LGE-MRI Image Post-ablation LGE-MRI Image Segmentation of LGE-MRI Image
Carma ex pre.png
Carma ex post.png
Carma ex pre seg.png
MRA Image Immediately Post-ablation (IPA) LGE-MRI Image
Carma ex mra.png
Carma no reflow.png

Registration Case Types

Pre to Post LGE-MRI

Pre to Pre LGE-MRI

Post to Post LGE-MRI

MRA to LGE-MRI

MRA to MRA

Immediately-Post to Post LGE-MRI

CT to LGE-MRI

Vector-Valued Registration

Implementation

  • We need to define a suitable set of registration parameters for each of the above cases
  • We will develop a Slicer extension module with the pre-defined registration parameters for each of the above scenarios
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