Difference between revisions of "DBP: Andy Saykin visit BWH and MIT April 21"

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'''PRESENT'''<nowiki>: Andy Saykin, Martha Shenton, Sonia Pujol, C-F Westin, Sandy Wells, Mark Dreusicke </nowiki>
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== Thursday, April 21 at Brigham and Women's Hospital: ==
  
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<br />
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* Noon: HCNR Talk at BWH "Memory Circuitry in Preclinical Alzheimer's Disease: Integrating Cognition, Neuroimaging, and Genetics"
  
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'''Topics Discussed:'''
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Location: [http://www.hcnr.med.harvard.edu/memberResources/directions.php#goldenson Goldenson Building, Harvard Medical School Quad, 220 Longwood Avenue], Room 122
  
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<br />'''Slicer Workshop at Dartmouth, May 26th and 27th'''
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* 1-2pm: lunch
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* 2-5pm: Working meeting (with Martha Shenton and others) to cover the following topics:
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** '''Click [[DBP:_Andy_Saykin_visit_BWH_and_MIT_April_21-22_2005:_Saykin_Meeting_4-21_Minutes|here]] for a summary of the topics covered at the meeting'''
  
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* Sonia is organizing the material that will be covered at the workshop
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<br />
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* Dr. Saykin would like an introductory overview of Slicer’s capabilities
 
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** Emphasis should be placed on structural analysis (labelmap drawing, etc.)
 
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** Overview of DTI capabilities should be briefly covered as well
 
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* Specific issues of concern include:
 
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** I/O file format, i.e., making sure current data at Dartmouth can be read (analyze format)
 
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** comparing BWH "pipeline" processing protocols with Dartmouth protocols (automatic segmentation, etc.)
 
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* '''Note for Dartmouth researchers:''' Click [[Slicer:Slicer2.4_Getting_Started|here]] for instructions on getting started with Slicer
 
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<br />'''Implementation plans for fMRI tasks at the BWH site'''
 
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* BWH should imitate the Dartmouth processing sequence
 
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* Marek Kubicki will be in touch Dr. Saykin, with the goal of having the fMRI sequence up and running at BWH by the end of June
 
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* Initial test cases should be scanned at BWH and sent to Dartmouth for analysis, to ensure software/acquisition compatibility
 
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* Testing protocols will need to be developed (similar to test datasets used by BIRN and ADNI)
 
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* More specific details will be discussed at a future meeting (see below)
 
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<br />'''DTI acquisition sequences'''
 
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* Dartmouth is expecting to have a new scanner in the fall
 
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* Both BWH and Dartmouth will be updating their acquisition protocols (using parallel imaging, etc.) to obtain higher resolution data
 
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* Details on updating DTI procedures also will be discussed at a future meeting (see below)
 
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<br />'''Analytic strategies for integrating structural connectivity and functional connectivity'''
 
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* Connectivity analyses will depend on close collaboration between sites to determine technical aspects of acquisition and coregistration of images
 
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* For now, both sites should keep in mind their technical procedures when analyzing structural, DTI, and fMRI images, so that the "nuts and bolts" can be discussed later
 
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<br />'''Overlap and differences in clinical and neurocognitive measures being obtained'''
 
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* BWH/Harvard and Dartmouth appear to be using the same clinical measures (DSM IV diagnosis, CVLT, etc.)
 
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* Each center will look into the medication equivalents used
 
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<br />'''Outstanding IRB issues'''
 
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* Marty will incorporate Dr. Saykin’s fMRI protocols into the IRB for U54
 
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<br />'''Potential recruitment from Dartmouth for Sandy Wells' PhD candidate student'''
 
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* Eric Cosman is a PhD student working with Sandy Wells on multivariate autoregressive modeling
 
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** This modeling may be used to study connectivity differences in populations
 
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* Dr. Saykin will follow up with Dr. Wells on the possibility of a collaboration, using patient/normal populations from Dartmouth
 
  
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<br />'''FUTURE MEETINGS'''
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== Friday, April 22 at MIT: ==
  
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* Future meetings will be held to further discuss these issues
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* 11am-12:30: Talk in 32-D507 "Analytic Strategies for Integrating Cognitive, Neuroimaging and Genetic Data: Application to Preclinical Alzheimer's Disease"
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* The possibility of a morning/afternoon session was discussed, with a date TBA
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* 12:30-1:30pm: lunch
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* Issues to be discussed include:
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* 1:30-3pm: Working meeting with the medical vision group. Our goals:
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** fMRI processing at BWH
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** Identify the areas of common interest netween the two groups
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** Incorporating LSDI scanning at Dartmouth
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** Plan the first collaborative project
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** The future of DTI at both test centers (pulse sequence, acquisition, etc.)
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** Understand Darthmouth group's needs for fMRI analysis
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* These meetings should include the following people:
 
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** Marek Kubicki
 
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** C-F Westin
 
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** Stephan Maier
 
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** Dave Tuck
 
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** Sandy Wells
 
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** Martha Shenton
 
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** Andy Saykin
 
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** Konstantinos Arfanakis
 

Revision as of 13:56, 18 December 2006

Home < DBP: Andy Saykin visit BWH and MIT April 21

Thursday, April 21 at Brigham and Women's Hospital:

  • Noon: HCNR Talk at BWH "Memory Circuitry in Preclinical Alzheimer's Disease: Integrating Cognition, Neuroimaging, and Genetics"

Location: Goldenson Building, Harvard Medical School Quad, 220 Longwood Avenue, Room 122

  • 1-2pm: lunch
  • 2-5pm: Working meeting (with Martha Shenton and others) to cover the following topics:
    • Click here for a summary of the topics covered at the meeting


Friday, April 22 at MIT:

  • 11am-12:30: Talk in 32-D507 "Analytic Strategies for Integrating Cognitive, Neuroimaging and Genetic Data: Application to Preclinical Alzheimer's Disease"
  • 12:30-1:30pm: lunch
  • 1:30-3pm: Working meeting with the medical vision group. Our goals:
    • Identify the areas of common interest netween the two groups
    • Plan the first collaborative project
    • Understand Darthmouth group's needs for fMRI analysis
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