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Objectives

to enhance interpretation of DICOM images through the use of 3D visualization and analysis
to gain experience with interactive, quantitative assessment of complex anatomical structures and functional images
to present current directions of quantitative imaging as a biomarker in clinical trials

Upon completion of this course, participants should be able to

Describe the methods used for basic analysis of quantitative imaging parameters
Describe the principles of image registration, segmentation, and volume measurement, and select and use appropriate software for 3D reconstruction
Identify key analysis and acquisition requirements for multi-center quantitative studies
Evaluate the impact of quantitative analysis methodology on their research interest

15 min (Kasia Macura): Overview of imaging biomarkers and their use in clinical trials
15 min (Randy Gollub): Generic principles of image registration, segmentation, visualization (technical aspects)
60 min (Jeff Yap+ others): Description and hands-on interactive demo for each of the imaging biomarkers and requirements for standardized acquisition in multi-center trials (e.g. RSNA QIBA)
- Hands-On: Volumetric MR analysis: tumor growth anaysis and measurements (~10 minutes)
- Hands-On: FDG-PET/CT (pre/post-therapy whole-body imaging with SUV quantification) (~10 minutes)
- DCE-MRI (~10 minutes)