Difference between revisions of "Inter-slice Motion Correction for fMRI"

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Objective:
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== Objective ==
  
 
     * To perform inter-slice motion correction in fMR images using affine and non-rigid registration methods.  
 
     * To perform inter-slice motion correction in fMR images using affine and non-rigid registration methods.  
  
Progress:
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== Progress ==
  
     * Implemented and tested b-Spline registration with Well Mutual Information metric.
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     * Implemented and tested b-Spline/affine registration with Wells-MI and KL metrics.
     * Working on affine motion correction using MI.
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== Results ==
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=== Affine ===
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* affine motion with all metrics degrades the inter-slice registration.  
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== Open questions ==
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     * Intensity normalization / histogram equalization - would these have any impact on inter-slice registration? Would they affect the computation of the joint-entropies for MI/KL metrics.
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    * Should there be some regularization factor on the registration to limit the motion ?
 
    
 
    
  
To Do:
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== To Do ==
  
 
     * Right now, registration is done on a slice by slice basis. However, due to the low resolution of fMRI and the absence of gradients result in low registration accuracy. We are investigating using alternative image-to-image metrics like the KL divergence. We are also looking at simultaneously registering multiple slices.  
 
     * Right now, registration is done on a slice by slice basis. However, due to the low resolution of fMRI and the absence of gradients result in low registration accuracy. We are investigating using alternative image-to-image metrics like the KL divergence. We are also looking at simultaneously registering multiple slices.  
  
Key Investigators:
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== Key Investigators ==
  
 
     * Firdaus Janoos, Raghu Machiraju, Steve Pieper, Wendy Plesniak.
 
     * Firdaus Janoos, Raghu Machiraju, Steve Pieper, Wendy Plesniak.
  
Links:
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== Links ==

Revision as of 09:07, 30 August 2007

Home < Inter-slice Motion Correction for fMRI

Objective

   * To perform inter-slice motion correction in fMR images using affine and non-rigid registration methods. 

Progress

   * Implemented and tested b-Spline/affine registration with Wells-MI and KL metrics.

Results

Affine

  • affine motion with all metrics degrades the inter-slice registration.


Open questions

   * Intensity normalization / histogram equalization - would these have any impact on inter-slice registration? Would they affect the computation of the joint-entropies for MI/KL metrics.
   * Should there be some regularization factor on the registration to limit the motion ? 
 

To Do

   * Right now, registration is done on a slice by slice basis. However, due to the low resolution of fMRI and the absence of gradients result in low registration accuracy. We are investigating using alternative image-to-image metrics like the KL divergence. We are also looking at simultaneously registering multiple slices. 

Key Investigators

   * Firdaus Janoos, Raghu Machiraju, Steve Pieper, Wendy Plesniak.

Links