Difference between revisions of "Linear Mixed-effects shape model to explore Huntington's Disease Data"

Revision as of 14:04, 20 June 2013

Home < Linear Mixed-effects shape model to explore Huntington's Disease Data

Projects List
fixed-effects slope for 7 control subjects (10 sub-cortical structures, 3 time points each). blue => expansion, yellow => contraction]
fixed-effects slope for 6 HD subjects (10 sub-cortical structures, 3 time points each). blue => expansion, yellow => contraction]

Make the linear mixed-effects shape model accessible for further exploration of Huntington's Disease Data

Meet with UIowa team to:

give an overview of results from the linear mixed-effects shape model
explain the ShapeWorks command line tools to optimze and analyze correspondences
discuss next steps toward making these tools accessible to UIowa team, to facilitate further exploration of the Huntington's disease Data

preliminary results look promising
ITKv4 module for mixed-effects model (Josh) available for Manasi to test
- ITKv4 module tested on Linux system
- Mixed-effects model for shapes from a single structure from the HD data (in progress)
Once tested, this module can be used by UIowa team on a larger cohort of cases

M Datar, P Muralidharan, A Kumar, S Gouttard, J Piven, G Gerig, RT Whitaker, PT Fletcher, Mixed-Effects Shape Models for Estimating Longitudinal Changes in Anatomy, STIA 2012

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 <gallery>
 Image:PW-MIT2013.png|[[2013_Summer_Project_Week#Projects|Projects List]]
-Image:fixedEffects01.png|fixed-effects (slope) [blue denotes expansion, yellow denotes contraction]
+Image:Ctrl01.png|fixed-effects slope for 7 control subjects (10 sub-cortical structures, 3 time points each). blue => expansion, yellow => contraction]
-Image:fixedEffects02.png|fixed-effects (slope) [blue denotes expansion, yellow denotes contraction]
+Image:HD01.png|fixed-effects slope for 6 HD subjects (10 sub-cortical structures, 3 time points each). blue => expansion, yellow => contraction]
 </gallery>