Linear Mixed-effects shape model to explore Huntington's Disease Data

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Home < Linear Mixed-effects shape model to explore Huntington's Disease Data

Key Investigators

  • UIowa: Hans Johnson, Dave Welch
  • Utah: Manasi Datar, Josh Cates, Ross Whitaker

Objective

Make the linear mixed-effects shape model accessible for further exploration of Huntington's Disease Data

Approach, Plan

Meet with UIowa team to:

  • give an overview of results from the linear mixed-effects shape model
  • explain the ShapeWorks command line tools to optimze and analyze correspondences
  • discuss next steps toward making these tools accessible to UIowa team

Progress

  • preliminary results look promising
  • ITKv4 module for mixed-effects model available
    • ITKv4 module tested on Linux system
    • Mixed-effects model for shapes from a single structure from the HD data (in progress). This should result in:
      • application (source code) to run mixed-effects shape model for HD data
      • an example parameter file
  • To Do
    • get working code for shape complexes (multiple structures per shape)
    • work on extracting labels from input labelmap (various components in the shape) - possibly add a tool to the preprocessing stage ?


References

M Datar, P Muralidharan, A Kumar, S Gouttard, J Piven, G Gerig, RT Whitaker, PT Fletcher, Mixed-Effects Shape Models for Estimating Longitudinal Changes in Anatomy, STIA 2012