Linear Mixed-effects shape model to explore Huntington's Disease Data
From NAMIC Wiki
Home < Linear Mixed-effects shape model to explore Huntington's Disease Data
Key Investigators
- UIowa: Hans Johnson, Dave Welch
- Utah: Manasi Datar, Josh Cates, Ross Whitaker
Objective
Make the linear mixed-effects shape model accessible for further exploration of Huntington's Disease Data
Approach, Plan
Meet with UIowa team to:
- give an overview of results from the linear mixed-effects shape model
- explain the ShapeWorks command line tools to optimze and analyze correspondences
- discuss next steps toward making these tools accessible to UIowa team, to facilitate further exploration of the Huntington's disease Data
Progress
- preliminary results look promising
- ITKv4 module for mixed-effects model available
- ITKv4 module tested on Linux system
- Mixed-effects model for shapes from a single structure from the HD data (in progress). This should result in:
- application (source code) to run mixed-effects shape model for HD data
- an example parameter file
- To Do: get working code for shape complexes (multiple structures per shape)
References
M Datar, P Muralidharan, A Kumar, S Gouttard, J Piven, G Gerig, RT Whitaker, PT Fletcher, Mixed-Effects Shape Models for Estimating Longitudinal Changes in Anatomy, STIA 2012