Difference between revisions of "NA-MIC/Projects/Theme/Carto scar"

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{|
 
{|
 
|[[Image:ProjectWeek-2008.png|thumb|320px|Return to [[2008_Summer_Project_Week|Project Week Main Page]] ]]
 
|[[Image:ProjectWeek-2008.png|thumb|320px|Return to [[2008_Summer_Project_Week|Project Week Main Page]] ]]
|[[Image:genuFAp.jpg|thumb|320px|Scatter plot of the original FA data through the genu of the corpus callosum of a normal brain.]]
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|[[Image:scarmri_namic.jpg|thumb|320px|Image showing scar in the left atrium using MRI]]
|[[Image:genuFA.jpg|thumb|320px|Regression of FA data; solid line represents the mean and dotted lines the standard deviation.]]
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|[[Image:scar_carto_namic.jpg|thumb|320px|Image of scar by MRI registered to MR Angiogram, and to the EP RF ablation site data.]]
 
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===Key Investigators===
 
===Key Investigators===
* UNC: Isabelle Corouge, Casey Goodlett, Guido Gerig
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* Beth Israel Deaconess: Dana C. Peters
* Utah: Tom Fletcher, Ross Whitaker
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* Beth Israel Deaconess: Jason Taclas
  
  
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<h1>Objective</h1>
 
<h1>Objective</h1>
We are developing methods for analyzing diffusion tensor data along fiber tracts. The goal is to be able to make statistical group comparisons with fiber tracts as a common reference frame for comparison.
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We are developing methods for registering peri-procedural electrophysiological data showing sites of RF energy application (called Carto data) in the left atrium, with post-procedural MRI data, which shows regions of scarred left atrium, using an interative closest point algorithm (Z. Malchano et al).  The goal is to measure the distance between scar by MRI and ablation sites (Carto data) by  EP.
  
  
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<h1>Approach, Plan</h1>
 
<h1>Approach, Plan</h1>
  
Our approach for analyzing diffusion tensors is summarized in the IPMI 2007 reference below.  The main challenge to this approach is <foo>.
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Our approach for comparing the locations of scar to sites of RF ablation is summarized in the ISMRM 2008 reference below.  The main challenge to this approach is to measure the distance between each scarred pixel, and each RF ablation site, and then the distance from each RF ablation site, to the nearest scarred pixel.  <foo>.
  
Our plan for the project week is to first try out <bar>,...
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Our plan for the project week is to first try to measure the closest distances between MRI scar and Carto data <bar>,and then to measure distances between Carto data and closest scar. We also wish to colorize the Carto surface, based on voltage data. We also wish to streamline the MR angiography segmentation method.
 
</div>
 
</div>
  
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<h1>Progress</h1>
 
<h1>Progress</h1>
  
Software for the fiber tracking and statistical analysis along the tracts has been implemented. The statistical methods for diffusion tensors are implemented as ITK code as part of the [[NA-MIC/Projects/Diffusion_Image_Analysis/DTI_Software_and_Algorithm_Infrastructure|DTI Software Infrastructure]] project. The methods have been validated on a repeated scan of a healthy individual. This work has been published as a conference paper (MICCAI 2005) and a journal version (MEDIA 2006). Our recent IPMI 2007 paper includes a nonparametric regression method for analyzing data along a fiber tract.
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Software for the registration between electrophysiology Carto data and the MR angiogram has been implemented, using the ITK/VTK platform (see ISMRM 2008 abstract, Taclas et al).  
  
 
</div>
 
</div>
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===References===
 
===References===
* Fletcher, P.T., Tao, R., Jeong, W.-K., Whitaker, R.T., "A Volumetric Approach to Quantifying Region-to-Region White Matter Connectivity in Diffusion Tensor MRI," to appear Information Processing in Medical Imaging (IPMI) 2007.
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*Peters DC, Wylie JV, Hauser TH, Kissinger KV, Botnar RM, Essebag V, Josephson ME, Manning WJ. Detection of pulmonary vein and left atrial scar after catheter ablation with three-dimensional navigator-gated delayed enhancement MR imaging: initial experience. Radiology 2007; 243:690-695.
* Corouge, I., Fletcher, P.T., Joshi, S., Gilmore, J.H., and Gerig, G., "Fiber Tract-Oriented Statistics for Quantitative Diffusion Tensor MRI Analysis," Medical Image Analysis 10 (2006), 786--798.
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* Taclas JE, Wylie JV, Hauser TH, Manning WJ, Josephson ME, Peters, DC. Correlation and Visualization of Left Atrial Scar due to Pulmonary Vein Ablation with Recorded Ablation Sites. Proceedings of the 16th scientific meeting of the International Society for Magnetic Resonance in Medicine (2008), Toronto, CA, p. 1042.
* Corouge, I., Fletcher, P.T., Joshi, S., Gilmore J.H., and Gerig, G., Fiber Tract-Oriented Statistics for Quantitative Diffusion Tensor MRI Analysis, Lecture Notes in Computer Science LNCS, James S. Duncan and Guido Gerig, editors, Springer Verlag, Vol. 3749, Oct. 2005, pp. 131 -- 138
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*Malchano ZJ, Neuzil P, Cury RC, Holmvang G, Weichet J, Schmidt EJ, Ruskin JN, Reddy VY. Integration of cardiac CT/MR imaging with three-dimensional electroanatomical mapping to guide catheter manipulation in the left atrium: implications for catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 2006; 17:1221-1229.
* C. Goodlett, I. Corouge, M. Jomier, and G. Gerig, A Quantitative DTI Fiber Tract Analysis Suite, The Insight Journal, vol. ISC/NAMIC/ MICCAI Workshop on Open-Source Software, 2005, Online publication: http://hdl.handle.net/1926/39 .
 

Revision as of 19:26, 11 June 2008

Home < NA-MIC < Projects < Theme < Carto scar
Image showing scar in the left atrium using MRI
Image of scar by MRI registered to MR Angiogram, and to the EP RF ablation site data.



Instructions for Use of this Template

  1. Please create a new wiki page with an appropriate title for your project using the convention NA-MIC/Projects/Theme-Name/Project-Name
  2. Copy the entire text of this page into the page created above
  3. Link the created page into the list of projects for the project event
  4. Delete this section from the created page
  5. Send an email to tkapur at bwh.harvard.edu if you are stuck

Key Investigators

  • Beth Israel Deaconess: Dana C. Peters
  • Beth Israel Deaconess: Jason Taclas


Objective

We are developing methods for registering peri-procedural electrophysiological data showing sites of RF energy application (called Carto data) in the left atrium, with post-procedural MRI data, which shows regions of scarred left atrium, using an interative closest point algorithm (Z. Malchano et al). The goal is to measure the distance between scar by MRI and ablation sites (Carto data) by EP.


Approach, Plan

Our approach for comparing the locations of scar to sites of RF ablation is summarized in the ISMRM 2008 reference below. The main challenge to this approach is to measure the distance between each scarred pixel, and each RF ablation site, and then the distance from each RF ablation site, to the nearest scarred pixel. <foo>.

Our plan for the project week is to first try to measure the closest distances between MRI scar and Carto data <bar>,and then to measure distances between Carto data and closest scar. We also wish to colorize the Carto surface, based on voltage data. We also wish to streamline the MR angiography segmentation method.

Progress

Software for the registration between electrophysiology Carto data and the MR angiogram has been implemented, using the ITK/VTK platform (see ISMRM 2008 abstract, Taclas et al).



References

  • Peters DC, Wylie JV, Hauser TH, Kissinger KV, Botnar RM, Essebag V, Josephson ME, Manning WJ. Detection of pulmonary vein and left atrial scar after catheter ablation with three-dimensional navigator-gated delayed enhancement MR imaging: initial experience. Radiology 2007; 243:690-695.
  • Taclas JE, Wylie JV, Hauser TH, Manning WJ, Josephson ME, Peters, DC. Correlation and Visualization of Left Atrial Scar due to Pulmonary Vein Ablation with Recorded Ablation Sites. Proceedings of the 16th scientific meeting of the International Society for Magnetic Resonance in Medicine (2008), Toronto, CA, p. 1042.
  • Malchano ZJ, Neuzil P, Cury RC, Holmvang G, Weichet J, Schmidt EJ, Ruskin JN, Reddy VY. Integration of cardiac CT/MR imaging with three-dimensional electroanatomical mapping to guide catheter manipulation in the left atrium: implications for catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 2006; 17:1221-1229.