Projects:AttentionalCircuitsInSchizophreniaInfMRIAndPET

Attentional Circuits in Schizophrenial InfMRIA and Pet

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Objective

To use structural equation modeling to compare attentional circuitry within the legacy set of 28 schizophrenic subjects who performed similar attentional tasks in both a PET and fMRI scan.

Progress

The data have been analyzed and segmented into a Talairach-based analysis. The mean glucose metabolism has been measured in the PET data on a region by region basis and the mean contrast values in the same regions have been measured in the fMRI data. A structural equation model is being defined for comparison among the two datasets. However, the segmentations are crude at best, and once the methods have been implemented on these regions, a second analysis using the improved segmentation methods will be implemented using FreeSurfer derived segmentations.

Key Investigators

David Keator, Jessica Turner, James Fallon, Steven Potkin, David Medina-Fuentes

Links

• The data can be found via the NAMIC website: http://www.na-mic.org/Wiki/index.php/DataRepository#UCI_Structural.2C_Functional_and_PET_Images.2C_Genetic_and_Clinical_Data