Difference between revisions of "Projects:CorpusCallosumRegionalFAAnalysis"

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<div class="thumb tleft"><div style="width: 182px">[[Image:FACorpus.png|[[Image:180px-FACorpus.png|Trans-callosal Fibers]]]]<div class="thumbcaption"><div class="magnify" style="float: right">[[Image:FACorpus.png|[[Image:magnify-clip.png|Enlarge]]]]</div>'''Trans-callosal Fibers'''</div></div></div>
 

Revision as of 15:04, 17 April 2007

Home < Projects:CorpusCallosumRegionalFAAnalysis
Back to NA-MIC_Collaborations

Objective: To quantify diffusion fractional anisotropy (FA) differences between controls and schizophrenia subjects within anatomicaly defined portions of the corpus callosum.

Progress:

  • We are in the process of applying population clustering algorythm to the NAMIC chronic schizophrenia data. Corpus callosum masks have been already drawn manually in slicer, and combined with fiber tractography clustering output. Several clusters of fiber tracts going through the corpus callosum have been identified, and now corpus masks will be back-painted and separated according to clusters.
  • In a separate analysis, a probabilistic regional parcellation shape model derived by tracking inter-hemispheric lobar DTI connections has been applied. The corpus callosum contours and respective 4 probabilistic parcellations were computed from the structural MRI automatically using a Fourier descriptor based active shape segmentation. The probabilistic masks were non-rigidly registered to the DTI base image and used for probabilistic histogram computation of the FA.

References

M. Styner, R. Gimpel Smith, C. Cascio, I. Oguz, M. JomierL: Corpus Callosum Subdivision based on a Probabilistic Model of Inter-hemispheric Connectivity, Medical Image Computing and Computer Assisted Interventions 2005, LNCS 3750, pp. 765-772.

Key Investigators:

  • Harvard PNL: Marek Kubicki, Mark Dreusicke, Doug Markant, Martha Shenton
  • MIT: Lauren O'Donnell, Carl-Fredrik Westin
  • UNC: Martin Styner


Links:


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