Projects:IntegrityOfFrontoTemporalCircuitry

Integrity of Fronto-Temporal Circuitry in Schizophrenia using Path of Interest Analysis

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Objective

To develop methodology that will permit investigators to specify functional MRI regional of interests (fROI) and determine the optimal white matter pathways between the fROIs based on DTI.

Progress

Working path of interest tool at Dartmouth that is currently being tested further. We've had success on mapping out uncinate fasciculus and arcuate fasciculus in a healthy adult. Next step will be to apply the methodology in a larger sample of subjects to verify reliability within and across subjects.

Update from AHM 2007

John West had training session with Dennis Jen on new version of POI algorithm. Worked together to read new Dartmouth 3T Philips Data. Further work ongoing to integrate POI into Slicer 3.

Key Investigators:

• Dartmouth: Andrew Saykin, John West, Robert Roth, Laura Flashman
• Harvard: Dennis Jen, Dave Tuch, Josh Snyder, Steve Pieper, Gordon Kindlmann

Links

• Path of Interest Algorithm Development