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Semi-Automatic Image Registration

We recognize that the difference between a failure of an automatic image registration approach and a success of a semi-automatic method can be a small amount of user input. The goal of this work is to register two CT volumes of different patients that are related by a large misalignment. The user sets two thresholds for each image: one for the bone mask and another for the flesh tissue. This operation is not time consuming but simplifies the registration task dramatically for the automatic algorithm.


In this example, large misalignment is present between the two patients.

  • PreRegFleshSkeleton

Original Misalignment of the volumes.

Point clouds are generated from label maps of bone. The computed registration field, which is guaranteed to be injective, is applied to the original CT volumes.

  • SkeletonMisalignedView1 SkeletonMisalignedView1

Point clouds representing bone tissue of the patients (before and after registration).

Another set of point clouds is generated by sampling from label maps of flesh. To avoid undoing the previous registration, regions belonging to the registered bone tissue from above are constrained not to move. Again, an injective deformation field is computed.

  • FleshMis FleshAlignedView1

Point clouds representing flesh tissue of the patients (before and after registration). This step is constrained.

The result of applying the two deformations computed by the proposed process are shown below.

  • PostRegFleshSkeleton

Aligned images using the two step registration process.

Current State of Work

A pipeline composed of Matlab and mex-ed C++ code has been implemented.

Key Investigators

  • Georgia Tech: Ivan Kolesov, Patricio Vela
  • Boston University: Jehoon Lee, Allen Tannenbaum
  • MGH: Gregory Sharp


In Press

I. Kolesov, J. Lee, P.Vela, G. Sharp and A. Tannenbaum. Diffeomorphic Point Set Registration with Landmark Constraints. In Preparation for PAMI.