Projects:RegistrationLibrary:RegLib C04:About

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Multiple Sclerosis Natural History Study

The images in this case and the time-lapse movie shown below is from a unique longitudinal study, where MS patients underwent weekly to monthly examination including pre- and post-contrast MRI as well as a full clinical evaluation with assessment of clinical disability scores. Because the study was performed before effective disease-modifying treatments became available, it represents a unique snapshot of the natural history of MS that can no longer be reproduced today. The full power of this dataset on visualizing the unique dynamics of MS becomes apparent only after extensive preprocessing that involves spatial registration, intensity-normalization, partial volume filtering and other corrections. For more details see the SPL publication database:


Example time lapse of a single MS patient of the course of 1 year