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Multiple Sclerosis Natural History Study

The images in this case and the time-lapse movie shown below is from a unique longitudinal study, where MS patients underwent weekly to monthly examination including pre- and post-contrast MRI as well as a full clinical evaluation with assessment of clinical disability scores. Because the study was performed before effective disease-modifying treatments became available, it represents a unique snapshot of the natural history of MS that can no longer be reproduced today. The full power of this dataset on visualizing the unique dynamics of MS becomes apparent only after extensive preprocessing that involves spatial registration, intensity-normalization, partial volume filtering and other corrections. On average 25 separate exams were co-registered for each movie shown. You will find more details in the following articles in the SPL publication database:

1.Seasonal Prevalence of MS Disease Activity. Neurology 2010
2.MR Imaging Intensity Modeling of Damage and Repair In Multiple Sclerosis: Relationship of Short-Term Lesion Recovery to Progression and Disability. AJNR 2007
3.Time-series Modeling of Multiple Sclerosis Disease Activity: A Promising Window on Disease Progression and Repair Potential? Neurotherapeutics. 2007
4.MRI Time Series Modeling of MS Lesion Development. NeuroImage 2006
5.Time-series Analysis of MRI Intensity Patterns in Multiple Sclerosis. NeuroImage 2003

For presentations including the animation below please cite Meier et al. , NeuroImage 2003; 20(2):1193-209. for the image analysis methodology and Weiner et al. , J Neuroimmunol 2000; 104(2):164-73. for the data origin.

Example time lapse of a single MS patient of the course of 1 year
Example time lapse animation of a single lesion showing significant recovery Example time lapse animation of a single lesion showing little to no recovery Example time lapse animation of a single lesion showing propagation along the WM