Projects:BrainActivationDuringContinuousVerbalEncodingAndRecognitionTaskInSchizophrenia
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Objective: This project employs an event-related auditory verbal episodic memory probe targeting medial temporal and DLPFC circuitry. The task uses a continuous performance format where concrete nouns are presented initially as new items. Words are then repeated after short or long intervals and the participant is required to make a new/old distinction. This design permits analysis of both encoding and recognition processes.
Progress: To date, data have been collected on 8 patients with schizophrenia and 5 healthy controls. Preliminary analysis on a subset of this data has been completed (see figure below). Sample data is available and more data will become available in year three.
Year Three Update: Data collection and analysis is ongoing. Updated results are expected at the end of year three.
Key Investigators:
- Dartmouth: Andrew Saykin, Robert Roth, Laura Flashman, John West, Thomas McAllister
- Harvard: Martha Shenton, Marek Kubicki
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