Difference between revisions of "2011 Winter Project Week:DTI MRI Registration"

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==Key Investigators==
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==Key Partners==
 
* Utah: Anuja Sharma, Guido Gerig
 
* Utah: Anuja Sharma, Guido Gerig
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* UNC: Martin Styner (Core 1)
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* Iowa: Hans Johnson (HD Project)
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* UCLA: Jack Van Horn (TBI Project)
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<h3>Objective</h3>
 
<h3>Objective</h3>
  
To work on Traumatic Brain Injury data sets (from UCLA) and aim to register their DTI data using atlas building. Post successful registration, changes in the DTI data as a result of TBI would be studied.
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To work on longitudinal DTI data from Traumatic Brain Injury data sets and Huntington's disease datasets. The aim is to analyze changes in diffusion in individual patients' follow up images. In the process, explore the inventory of tools needed (existing within or outside Slicer/ITK) and challenges faced in achieving the same, focusing mainly on DTI registration.
 
 
As a collaborative effort with University of Iowa (Psychiatry), we might also be working on longitudinal analysis of DTI scans for Huntington's disease.
 
 
   
 
   
  
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<h3>Approach, Plan</h3>
 
<h3>Approach, Plan</h3>
  
For TBI data, registration techniques like large deformation diffeomorphic mapping (LDDMM) and other nonlinear registration schemes would be compared and evaluated for feasibility. Another possibility would be to attempt registration between DTI scans using the corresponding sMRI scans which would be registered independently as the first step (being worked on by Bo Wang et al. from University of Utah).  
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Begin with utilizing the existing DTI registration resources for co-registering the images from individual subjects (at varying timepoints: intra-subject). The input images would be scalars derived from the DWI/DTI inputs. For the specific scenarios of TBI and HD, different algorithms/parameter settings for registration would be compared. The aim is to build an atlas using the transformed images and getting transformation fields back to each timepoint image. This would be applied to deform the tensor field and finally come up with a DTI atlas.
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Post successful DTI atlas building, we would proceed with tractography followed by arc-length parametrization along the fiber bundles and the use of existing DTI-statistical-analysis framework with along-tract kernel regression. The framework was originally developed by Casey Goodlett and has been modified and updated by the Utah and UNC groups.
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For the longitudinal analysis of DTI from HD subjects, we would use the existing DTI-statistical-analysis framework with along-tract kernel regression, followed by population based analysis to study disease related changes. The framework was originally developed by Casey Goodlett and has been modified and updated by the Utah and UNC groups.
 
  
 
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Latest revision as of 12:34, 10 January 2011

Home < 2011 Winter Project Week:DTI MRI Registration

Key Partners

  • Utah: Anuja Sharma, Guido Gerig
  • UNC: Martin Styner (Core 1)
  • Iowa: Hans Johnson (HD Project)
  • UCLA: Jack Van Horn (TBI Project)


Objective

To work on longitudinal DTI data from Traumatic Brain Injury data sets and Huntington's disease datasets. The aim is to analyze changes in diffusion in individual patients' follow up images. In the process, explore the inventory of tools needed (existing within or outside Slicer/ITK) and challenges faced in achieving the same, focusing mainly on DTI registration.


Approach, Plan

Begin with utilizing the existing DTI registration resources for co-registering the images from individual subjects (at varying timepoints: intra-subject). The input images would be scalars derived from the DWI/DTI inputs. For the specific scenarios of TBI and HD, different algorithms/parameter settings for registration would be compared. The aim is to build an atlas using the transformed images and getting transformation fields back to each timepoint image. This would be applied to deform the tensor field and finally come up with a DTI atlas.

Post successful DTI atlas building, we would proceed with tractography followed by arc-length parametrization along the fiber bundles and the use of existing DTI-statistical-analysis framework with along-tract kernel regression. The framework was originally developed by Casey Goodlett and has been modified and updated by the Utah and UNC groups.


Progress

References