2014 Project Week:Multi-Tissue Stroke Segmentation

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Home < 2014 Project Week:Multi-Tissue Stroke Segmentation

Key Investigators

  • Ramesh Sridharan, Adrian Dalca, Polina Binder, Polina Golland, MIT
  • Natalia Rost, Jonathan Rosand, MGH

Project Description


We have developed some methods for segmentation of white matter hyperintensity (WMH) in FLAIR images of stroke patients. We want to extend our framework to do multi-modal segmentation of multiple tissue types (in our case, stroke lesions, white matter hyperintensity, and normal tissue using T1, FLAIR, DWI, and possibly ADC images). This dataset is particularly challenging due to the low resolution (typically 1mm x 1mm x 7mm) and cropped fields of view in the given images.

Approach, Plan

  • Identify intensity and shape signatures of different tissue types across images


  • Implemented mixture model for multimodal intensity
  • Segmented stroke and white matter hyperintensity, but oversegments: need to find a way to be more specific