2014 Summer Project Week:Cortical Dysplasia Identification

Key Investigators

• Luiz Murta
• Emylin Souza
• Tina Kapur
• Ron Kikinis

Project Description

Objective

• Find, construct and validate tools to investigate the presence and location of the epileptogenic focus through analysis of: cortical thickness, texture patterns.
• Investigates image registration as computational tool to compare pre and post MRI in epilepsy surgery.

Approach, Plan

• Structure and tissue segmentation of cortex.
• Cortical thickness evaluation, grey matter texture analysis.
• Pre and post surgical MRI registration, localization of resection.

Progress

• Gray matter segmentation using expectation-maximization (EMS) algorithm has shown accuracy and robustness in cortical dysplasia data.
• Started understanding and adapting existing code (ARCTIC) to estimate thickness. (with the of Clement Vachet and Marcel Prastawa and Marcel Prastawa)
• Scripted module for registration between pre- and post-surgical volumes and quadratic difference volume computation to highlight resection. (almost done, thanks to help from Jim Miller and Steve Piepen)